Functional analysis of G6PD variants associated with low G6PD activity in the All of Us Research Program [0.03%]
美国全民计划中与G6PD活性降低相关的G6PD变异体的功能分析
Nicholas R Powell,Renee C Geck,Dongbing Lai et al.
Nicholas R Powell et al.
The glucose-6-phosphate dehydrogenase (G6PD) enzyme protects red blood cells against oxidative damage. Individuals with G6PD-impairing polymorphisms are at risk of hemolytic anemia from oxidative stressors. Prevention of G6PD deficiency-rel...
Two coacting shadow enhancers regulate twin of eyeless expression during early Drosophila development [0.03%]
两个相互作用的阴影增强子在果蝇早期发育过程中调节眼睛同源盒基因的表达
Jacqueline M Dresch,Luke L Nourie,Regan D Conrad et al.
Jacqueline M Dresch et al.
The Drosophila PAX6 homolog twin of eyeless (toy) sits at the pinnacle of the genetic pathway controlling eye development, the retinal determination network. Expression of toy in the embryo is first detectable at cellular blastoderm stage 5...
Clarence Zheng,Curtis Furukawa,Jerry Liu et al.
Clarence Zheng et al.
For decades, it has been repeatedly claimed that the potent bacterial helicase-nuclease RecBCD (exonuclease V) destroys foreign (non-self) DNA, such as that of phages, but repairs and recombines cellular (self) DNA. While this would constit...
Different complex regulatory phenotypes underlie hybrid male sterility in divergent rodent crosses [0.03%]
不同啮齿动物杂交种中复杂的调控表型决定了雄性不育现象
Kelsie E Hunnicutt,Colin Callahan,Sara Keeble et al.
Kelsie E Hunnicutt et al.
Hybrid incompatibilities are a critical component of species barriers and may arise due to negative interactions between divergent regulatory elements in parental species. We used a comparative approach to identify common themes in the regu...
Rok Grah,Calin C Guet,Gasper Tkačik et al.
Rok Grah et al.
A major obstacle to predictive understanding of evolution stems from the complexity of biological systems, which prevents detailed characterization of key evolutionary properties. Here, we highlight some of the major sources of complexity t...
James Hose,Qi Zhang,Nathaniel P Sharp et al.
James Hose et al.
Aneuploidy, arising from gain or loss of chromosomes due to nondisjunction, is a special class of mutation. It can create significant phenotypic changes by altering abundance of hundreds of genes in a single event, providing material for ad...
MalKinID: A Classification Model for Identifying Malaria Parasite Genealogical Relationships Using Identity-by-Descent [0.03%]
基于血统关系的疟疾 parasite 基因身份识别分类模型 MalKinID
Wesley Wong,Lea Wang,Stephen S Schaffner et al.
Wesley Wong et al.
Pathogen genomics is a powerful tool for tracking infectious disease transmission. In malaria, identity-by-descent (IBD) is used to assess the genetic relatedness between parasites and has been used to study transmission and importation. In...
Global Genotype by Environment Prediction Competition Reveals That Diverse Modeling Strategies Can Deliver Satisfactory Maize Yield Estimates [0.03%]
全球基因型与环境预测竞赛：多样化的模型策略可以提供令人满意的玉米产量估算结果
Jacob D Washburn,José Ignacio Varela,Alencar Xavier et al.
Jacob D Washburn et al.
Predicting phenotypes from a combination of genetic and environmental factors is a grand challenge of modern biology. Slight improvements in this area have the potential to save lives, improve food and fuel security, permit better care of t...
Bayesian hierarchical hypothesis testing in large-scale genome-wide association analysis [0.03%]
大型全基因组关联分析中的贝叶斯分层假设检验方法研究
Anirban Samaddar,Tapabrata Maiti,Gustavo de Los Campos
Anirban Samaddar
Variable selection and large-scale hypothesis testing are techniques commonly used to analyze high-dimensional genomic data. Despite recent advances in theory and methodology, variable selection and inference with highly collinear features ...