Alexane Jouniaux,Armando Arredondo,Simon Boitard et al.
Alexane Jouniaux et al.
Population genetic studies use genetic data to understand aspects of the evolutionary history of species. Here, we extend the piecewise-homogeneous structured coalescent framework to complex models where the parameters of the model, and thu...
Mapping Whole-Organism Genetic Comorbidities Across Model Species Using Unified Ontologies [0.03%]
基于统一本体跨物种绘制全基因组遗传共病图谱
Caitlin Peaslee,Madison Held,Eloise Fadial et al.
Caitlin Peaslee et al.
Understanding how genetic variation contributes to organism-wide phenotypes is critical for identifying mechanisms of disease. Here, we present a computational approach to analyze whole-organism comorbidities associated with genes underlyin...
Yaf9 Connects NuA4 and SWR1 Functions to Maintain Genome Integrity [0.03%]
YAF9连接NuA4和SWR1的功能以维持基因组完整性
Henel Jürgens,Signe Värv,Kersti Kristjuhan et al.
Henel Jürgens et al.
Precise regulation of chromatin structure is essential for ensuring genome stability and cellular function. In Saccharomyces cerevisiae, the YEATS (Yaf9-ENL-AF9-Taf14-Sas5) domain protein Yaf9 is a shared component of the NuA4 acetyltransfe...
A Genetic Screen for Regulators of Drosophila Histone H1 Binding and Chromosome Structure In Vivo [0.03%]
活体果蝇组蛋白H1结合和染色体结构调节因子的遗传筛选
Giorgia Siriaco,Gina D Mawla,Kristin E Cutler et al.
Giorgia Siriaco et al.
Histone H1 and related linker histones play critical roles in chromosome organization in eukaryotic cells. Although histone H1 is essential for compacting nucleosomes into chromatin fibers and is a major structural component of chromosomes,...
Assessment of segregation variance estimates from derivation, simulations, and empirical data in autotetraploid species exemplified in potato [0.03%]
基于马铃薯自交系、模拟和实测数据评估同源四倍体物种分离方差估算值
Po-Ya Wu,Kathrin Thelen,Stefanie Hartje et al.
Po-Ya Wu et al.
The optimal choice of parents and crosses and, therefore, the prediction of the segregation variance are of high relevance to maximize genetic gain in breeding programs. Several methods have been developed for the prediction of segregation ...
Two populations of heteromeric acetylcholine receptors are present at C. elegans neuromuscular junctions [0.03%]
秀丽隐杆线虫神经肌肉突触上存在两种异源二聚体乙酰胆碱受体群体
Greta Maiellano,Camilla Luccardini,Oceane Romatif et al.
Greta Maiellano et al.
Ligand-gated acetylcholine receptors (AChRs) are pentameric transmembrane proteins that display extensive molecular diversity through combinatorial assembly of subunits. In the nematode Caenorhabditis elegans, this diversity is exceptionall...
Genetic dissection of transcription start site selection by RNA Polymerase II in Saccharomyces cerevisiae [0.03%]
酿酒酵母中RNA聚合酶II转录起始位点选择的遗传解剖学研究
Payal Arora,Kieran F Brennan,Marcie H Warner et al.
Payal Arora et al.
Transcription initiation by RNA Pol II is driven by a preinitiation complex (PIC) comprising Pol II and general transcription factors (GTFs): TFIIA, TFIIB, TFIID, TFIIE, TFIIF and TFIIH. In Saccharomyces cerevisiae, transcription start site...
MAL33 drives natural variation in maltose metabolism in Saccharomyces eubayanus [0.03%]
MAL33驱动Saccharomyces eubayanus中麦芽糖代谢的自然变异
Pablo Quintrel,Felipe Muñoz-Guzmán,Pablo Villarreal et al.
Pablo Quintrel et al.
Maltose is one of the most abundant sugars in brewer's wort, and its efficient utilization is critical for successful fermentation. However, maltose consumption varies naturally among Saccharomyces eubayanus strains isolated from different ...
esBAF and INO8°C fine-tune subcompartments and differentially regulate enhancer-promoter interactions [0.03%]
esBAF和INO80微调亚区室并差异调节增强子-启动子相互作用
Braulio Bonilla,Benjamin J Patty,Snehal V Sambare et al.
Braulio Bonilla et al.
The genome is compacted in the nucleus through a hierarchical chromatin organization, ranging from chromosome territories to compartments, topologically associating domains (TADs), and individual nucleosomes. Nucleosome remodeling complexes...
Deposition of CENP-A Cse4 is enhanced by mutations in the AAA+ ATPase domain of ATAD2 Yta7 [0.03%]
ATAD2 Yta7的AAA+ ATPase结构域中的突变可增强CENP-A Cse4的沉积
Navpreet Kaur,Carol Cho,Anke Samel-Pommerencke et al.
Navpreet Kaur et al.
The chromatin remodelling factor and histone chaperone Yta7 is a member of the ATAD2 family of AAA+ ATPases from Saccharomyces cerevisiae that has in vivo functions consistent with both nucleosome assembly and disassembly activity. At the c...