John A Calarco,Seth R Taylor,David M Miller rd
John A Calarco
Reliable methods for detecting and analyzing gene expression are necessary tools for understanding development and investigating biological responses to genetic and environmental perturbation. With its fully sequenced genome, invariant cell...
Characterizing selection on complex traits through conditional frequency spectra [0.03%]
利用条件频率光谱表征复杂性状的自然选择
Roshni A Patel,Clemens L Weiß,Huisheng Zhu et al.
Roshni A Patel et al.
Natural selection on complex traits is difficult to study in part due to the ascertainment inherent to genome-wide association studies (GWAS). The power to detect a trait-associated variant in GWAS is a function of frequency and effect size...
A previously reported bottleneck in human ancestry 900 kya is likely a statistical artifact [0.03%]
此前报道的人类祖先于约90万年前出现的一个瓶颈很可能是一个统计假象
Yun Deng,Rasmus Nielsen,Yun S Song
Yun Deng
It was recently reported that a severe ancient bottleneck occurred around 900 thousand years ago in the ancestry of African populations, while this signal is absent in non-African populations. Here, we present evidence to show that this fin...
Robust sex determination in the Caenorhabditis nigoni germ line [0.03%]
Caenorhabditis nigoni生殖细胞系中的稳健性别决定
Jonathan P Harbin,Yongquan Shen,Shin-Yi Lin et al.
Jonathan P Harbin et al.
Sexual characteristics and reproductive systems are dynamic traits in many taxa, but the developmental modifications that allow change and innovation are largely unknown. A leading model for this process is the evolution of self-fertile her...
Two H3K23 histone methyltransferases, SET-32 and SET-21, function synergistically to promote nuclear RNAi-mediated transgenerational epigenetic inheritance in Caenorhabditis elegans [0.03%]
两项组蛋白甲基转移酶SET-32和SET-21在促进秀丽隐杆线虫核RNA介导的跨世代表观遗传继承过程中协同作用
Anna Zhebrun,Julie Z Ni,Laura Corveleyn et al.
Anna Zhebrun et al.
Nuclear RNAi in C. elegans induces a set of transgenerationally heritable marks of H3K9me3, H3K23me3, and H3K27me3 at the target genes. The function of H3K23me3 in the nuclear RNAi pathway is largely unknown due to the limited knowledge of ...
John P Hamilton,Julia Brose,C Robin Buell
John P Hamilton
Potato is a key food crop with a complex, polyploid genome. Advancements in sequencing technologies coupled with improvements in genome assembly algorithms have enabled generation of phased, chromosome-scale genome assemblies for cultivated...
The C. elegans LON-1 protein requires its CAP domain for function in regulating body size and BMP signaling [0.03%]
秀丽隐杆线虫LON-1蛋白的CAP结构域对其调控体型和BMP信号通路的功能是必需的
Maria Victoria Serrano,Stéphanie Cottier,Lianzijun Wang et al.
Maria Victoria Serrano et al.
The CAP (Cysteine-rich secretory proteins, Antigen-5, Pathogenesis-Related) proteins are widely expressed and have been implicated to play diverse roles ranging from mammalian reproduction to plant immune response. Increasing evidence suppo...
Metaxin-2 tunes mitochondrial transportation and neuronal function in Drosophila [0.03%]
Metaxin-2调节果蝇线粒体转运和神经元功能
Ting Zhang,Ling Li,Xiaoyu Fan et al.
Ting Zhang et al.
Metaxins are a family of evolutionarily conserved proteins that reside on the mitochondria outer membrane (MOM) and participate in the protein import into the mitochondria. Metaxin-2 (Mtx2), a member of this family, has been identified as a...
Proteolytic regulation of mitochondrial magnesium channel MRS2 by m-AAA protease and prohibitin complex [0.03%]
m-AAA蛋白酶和禁止素复合物对线粒体镁通道MRS2的蛋白水解调节
Alaumy Joshi,Rachel A Stanfield,Andrew T Spletter et al.
Alaumy Joshi et al.
Mitochondrial membrane phospholipid cardiolipin is essential for the stability of several inner mitochondrial membrane protein complexes. We recently showed that the abundance of mitochondrial magnesium channel MRS2 is reduced in models of ...
A mutation in DNA polymerase γ harbours a shortened lifespan and high sensitivity to mutagens in the filamentous fungus Neurospora crassa [0.03%]
DNA聚合酶γ中的一种突变体在丝状真菌神经孢子丝菌中的寿命较短且易发生基因突变
Ryouhei Yoshihara,Yuzuki Shimakura,Satoshi Kitamura et al.
Ryouhei Yoshihara et al.
Hyphal elongation is the vegetative growth of filamentous fungi, and many species continuously elongate their hyphal tips over long periods. The details of the mechanisms for maintaining continuous growth are not yet clear. A novel short li...