Alison Luciano,Laura Robinson,William H Schott et al.
Alison Luciano et al.
Dietary interventions such as caloric restriction and periodic fasting improve metabolic health and extend lifespan in preclinical models, yet individuals differ widely in their physiological responses-variation that remains poorly understo...
Beyond Mendel: a call to revisit the genotype-phenotype map through new experimental paradigms [0.03%]
超越孟德尔：通过新的实验范式重新审视基因型-表型图谱的呼吁
Diethard Tautz,Luisa F Pallares,Leif Andersson et al.
Diethard Tautz et al.
The long-standing notion that genotypes map to phenotypes through simple one gene-one trait relationships continues to shape both research in the life sciences and public understanding, with implications for policy and funding priorities. Y...
Mutational divergence over years in local populations of the selfing nematode Caenorhabditis elegans [0.03%]
自交秀丽隐杆线虫Caenorhabditis elegans品系几年间的单核苷酸多态性分化程度
Xu Wei,Aurélien Richaud,Robyn E Tanny et al.
Xu Wei et al.
Laboratory mutation accumulation experiments allow the assessment of spontaneous mutation rates and patterns with minimal selection. Here, we aimed to follow the accumulation and fate of mutations in natural populations, in a spatial contex...
The TWK-26/KCNK3 potassium channel and FLR-4 protein kinase coordinate nutrient absorption in the C. elegans intestine [0.03%]
TWK-26/KCNN3钾通道和FLR-4蛋白激酶协调秀丽隐杆线虫肠道的营养吸收
Sarah K Torzone,Trae Carroll,Peter C Breen et al.
Sarah K Torzone et al.
Ion channels are necessary for proper water and nutrient absorption in the intestine, thereby supporting cellular metabolism and organismal growth. While a role for Na+ co-transporters and pumps in intestinal nutrient absorption is well def...
IPMK-1 (inositol phosphate multikinase) is required for integrin adhesion complex organization and muscle cell adhesion in C. elegans [0.03%]
IPMK-1（肌醇磷酸多元激酶）是C.elegans整合素粘附复合体组织和肌肉细胞粘附所必需的
Sara Sagadiev,Robert Hudson Jr,Yuchu Wang et al.
Sara Sagadiev et al.
Integrin adhesion complexes (IACs) are a network of proteins that anchor cells to the extracellular matrix. In C. elegans muscle IACs exist at the bases of dense bodies and M-lines, and at the boundaries of adjacent muscle cells (MCBs). Pro...
Investigating the fruitless-directed molecular and circuit architecture of courtship behavior in Drosophila melanogaster, Drosophila simulans and their hybrids [0.03%]
利用果蝇(Drosophila melanogaster)、拟果蝇(Drosophila simulans)及其杂交种研究求偶行为的分子及回路结构
Colleen M Palmateer,Kelsey Claire Morris,Scott Nolting et al.
Colleen M Palmateer et al.
Understanding the mechanisms driving behavioral evolution enhances our knowledge of speciation and how behavioral potentials are encoded. Drosophila male courtship behaviors, which evolve rapidly, are directed by fruitless-expressing neuron...
Ariana José,Pravat Dhakal,Rossana Signorelli et al.
Ariana José et al.
Gαq signaling through Trio RhoGEF and Phospholipase C effectors promotes neurotransmitter release at synapses. Whether activated Rho and Phospholipase C signaling acts through shared or independent pathways remains unclear. We use the egg-...
Reflections on the Human Genome Diversity Project: a conversation with Marcus W. Feldman, Henry T. Greely, and Mary-Claire King [0.03%]
人类基因组多样性计划的新议题——与Marcus W. Feldman、Henry T. Greely和Mary-Claire King的对话
Sohini Ramachandran,Noah A Rosenberg
Sohini Ramachandran
The Human Genome Diversity Project (HGDP) began in 1991 as an initiative to study genetic variation from human populations worldwide. In 2002, the HGDP reported the HGDP-CEPH Human Genome Diversity Cell Line Panel, a global panel of 1064 ce...
Molecular insights into diverse heat hormesis regimens in Caenorhabditis elegans [0.03%]
利用线虫研究不同热休克处理的分子机制
Hsin-Yun Chang,Charles L Heinke,Siu Sylvia Lee
Hsin-Yun Chang
Heat hormesis describes a biphasic, dose-dependent response in which low levels of heat stress induce beneficial effects, such as enhanced lifespan and stress resilience. This phenomenon is commonly studied in Caenorhabditis elegans using r...
A quantitative genetic model for indirect genetic effects and genomic imprinting under random and assortative mating [0.03%]
随机交配和择优交配下的间接遗传效应和基因组印迹的定量遗传模型
Ilse Krätschmer,Matthew R Robinson
Ilse Krätschmer
An individual's phenotype reflects a complex interplay of the direct effects of their DNA, epigenetic modifications of their DNA induced by their parents, and indirect effects of their parents' DNA. Here, we derive how the genetic variance ...