Wolbachia pipientis Modulates Germline Stem Cells and Gene Expression Associated with Ubiquitination and Histone Lysine Trimethylation to Rescue Fertility Defects in Drosophila [0.03%]
沃尔巴克体通过调节泛素化和组蛋白赖氨酸三甲基化相关基因表达及卵原干细胞维持拯救果蝇繁殖缺陷
Catherine H Kagemann,Jaclyn E Bubnell,Gabriela M Colocho et al.
Catherine H Kagemann et al.
Wolbachia pipientis are maternally transmitted endosymbiotic bacteria commonly found in arthropods and nematodes. These bacteria manipulate reproduction of the host to increase their transmission using mechanisms, such as cytoplasmic incomp...
The ATP-dependent DEAD-box RNA Helicase Dbp2 regulates the glucose/nitrogen stress response in baker's yeast by modulating reversible nuclear retention and decay of SKS1 mRNA [0.03%]
ATP依赖的DEAD盒RNA解旋酶Dbp2通过调节酿酒酵母SKS1 mRNA的可逆核滞留和降解来调控葡萄糖/氮应激反应
Soumita Paul,Subhadeep Das,Mayukh Banerjea et al.
Soumita Paul et al.
In Saccharomyces cerevisiae, SKS1 mRNA encoding a glucose-sensing serine/threonine kinase belongs to "nucleus-retained" (NR) mRNAs representing a subset of otherwise normal transcripts, which exhibits slow nuclear export and excessively lon...
Bibhu Simkhada,Nestor O Nazario-Yepiz,Patrick S Freymuth et al.
Bibhu Simkhada et al.
Mucopolysaccharidosis type IIIB (MPS IIIB) is a rare lysosomal storage disorder caused by defects in alpha-N-acetylglucosaminidase (NAGLU) and characterized by severe effects in the central nervous system. Mutations in NAGLU cause accumulat...
Coenzyme Q improves mitochondrial and muscle dysfunction caused by CUG expanded repeats in Caenorhabditis elegans [0.03%]
辅酶Q改善了由扩展的CUG重复序列导致的秀丽隐杆线虫线粒体及肌肉功能障碍
Joana Teixeira,Anu-Mari Harju,Alaa Othman et al.
Joana Teixeira et al.
Expansion of nucleotide repeat sequences is associated with more than 40 human neuromuscular disorders. The different pathogenic mechanisms associated with the expression of nucleotide repeats are not well understood. We use a Caenorhabditi...
TAT-1, a phosphatidylserine flippase, affects molting and regulates membrane trafficking in the epidermis of C. elegans [0.03%]
TAT-1（磷脂酰丝氨酸翻转酶）影响蜕皮并调控C.elegans表皮膜转运
Shae M Milne,Philip T Edeen,David S Fay
Shae M Milne
Membrane trafficking is a conserved process required for import, export, movement, and distribution of proteins and other macromolecules within cells. The Caenorhabditis elegans NIMA-related kinases NEKL-2 (human NEK8/9) and NEKL-3 (human N...
A modular system to label endogenous presynaptic proteins using split fluorophores in C. elegans [0.03%]
一种使用分裂荧光团在秀丽隐杆线虫中给内源性突触前蛋白标记的系统
Mizuki Kurashina,Andrew W Snow,Kota Mizumoto
Mizuki Kurashina
Visualizing the subcellular localization of presynaptic proteins with fluorescent proteins is a powerful tool to dissect the genetic and molecular mechanisms underlying synapse formation and patterning in live animals. Here, we utilize spli...
Multiple DNA repair pathways prevent acetaldehyde-induced mutagenesis in yeast [0.03%]
多种DNA修复途径可防止乙醛诱发的酵母基因突变现象
Latarsha Porcher,Sriram Vijayraghavan,Yashvi Patel et al.
Latarsha Porcher et al.
Acetaldehyde is the primary metabolite of alcohol and is present in many environmental sources including tobacco smoke. Acetaldehyde is genotoxic, whereby it can form DNA adducts and lead to mutagenesis. Individuals with defects in acetalde...
CelEst: a unified gene regulatory network for estimating transcription factor activities in C. elegans [0.03%]
CelEst：一个统一的基因调控网络 估计果蝇基因转录因子活性
Marcos Francisco Perez
Marcos Francisco Perez
Transcription factors (TFs) play a pivotal role in orchestrating critical intricate patterns of gene regulation. Although gene expression is complex, differential expression of hundreds of genes is often due to regulation by just a handful ...
Allele ages provide limited information about the strength of negative selection [0.03%]
等位基因年龄有限地反映了负选择强度
Vivaswat Shastry,Jeremy J Berg
Vivaswat Shastry
For many problems in population genetics, it is useful to characterize the distribution of fitness effects (DFE) of de novo mutations among a certain class of sites. A DFE is typically estimated by fitting an observed site frequency spectru...