Sequence mismatch between gene-drive and target-site flanking regions significantly impairs homing efficiency in Culex quinquefasciatus [0.03%]
基因驱动基因与目标位点上下游序列的错配显著降低了埃及伊蚊中的同源重组效率
Tim Harvey-Samuel,Rajdeep Kaur,Philip T Leftwich et al.
Tim Harvey-Samuel et al.
CRISPR/Cas9-based homing gene-drives (homing-drives) hold enormous potential as control tools for mosquito disease-vectors. These genomically-encoded technologies spread themselves through target populations by creating double-stranded DNA ...
Protection from thiol reductive stress through an autoinhibitory hypoxia response pathway in Caenorhabditis elegans [0.03%]
利用自动抑制的缺氧响应途径防御硫醇还原型底物压力——以秀丽隐杆线虫为例
Ravi,Jogender Singh
Ravi
Cellular redox homeostasis depends on a finely tuned balance between oxidizing and reducing conditions, and disturbances in this balance lead to oxidative or reductive stress. While oxidative stress and its pathological outcomes are well st...
Sex Bias in Iron Sequestration by Transferrin 1 Modulates Sexually-Dimorphic Infection Outcomes in Drosophila melanogaster [0.03%]
果蝇铁调节蛋白1的性别偏好调控感染结果的性别二态性
Alexandra Hrdina,Igor Iatsenko
Alexandra Hrdina
Host sexual dimorphism in the outcome of infections is a ubiquitous phenomenon across taxa. However, the immunological differences between males and females and the mechanisms underlying them remain poorly characterized. Here, we used Droso...
Mutational landscape and molecular bases of echinocandin resistance in Saccharomyces cerevisiae [0.03%]
里氏裂殖酵母丝舒康啶抗性相关的突变谱和分子机制研究
Romain Durand,Alexandre G Torbey,Mathieu Giguere et al.
Romain Durand et al.
One of the front-line drug classes used to treat invasive fungal infections is echinocandins, which target the fungal-specific beta-glucan synthase (Fks). Treatment failure due to resistance often coincides with mutations in three protein r...
Detecting and Quantifying Networks of Biological Kinship via Exponential Family Random Graph Models [0.03%]
基于指数随机图模型检测和量化生物亲缘网络
Adam B Rohrlach,Guido Alberto Gnecchi-Ruscone,Zuzana Hofmanová et al.
Adam B Rohrlach et al.
Genetic relatedness between ancient humans can help to identify close and distant connections between groups and populations, uncovering signatures of demographic histories such as identifying mating networks or long-range migration. Critic...
Genetic analysis of polyadenylation patterns reveals distinct classes of yeast genes and local chromatin effects on Pol II elongation [0.03%]
多聚腺苷酸化模式的基因分析揭示了酵母基因的不同类型以及染色质对Pol II延伸的影响
Zarmik Moqtaderi,Joseph V Geisberg,Kevin Struhl
Zarmik Moqtaderi
The poly(A) profile of a typical yeast gene comprises ∼50 poly(A) sites corresponding to distinct 3' mRNA isoforms. Poly(A) profiles are shifted upstream in strains with slow RNA polymerase II (Pol II) elongation rates resulting from Pol I...
Linh Huynh,Razan A Fakieh,C&#x;Brionne Hendrix et al.
Linh Huynh et al.
Hippo is the namesake component of a conserved transduction cascade/regulator of tissue homeostasis and development across metazoans. The Ste20 family kinase Hippo/MST activates the NDR family kinase Warts/LATS to inhibit the transcriptiona...
Retinoic acid production via the ray-finned fish gene bco1l is essential for juvenile development [0.03%]
通过辐鳍鱼基因bco1l生成视黄酸对于幼体发育是必不可少的
Lochlan Sife Krupa,Paula R Villamayor,Sepalika Bandara et al.
Lochlan Sife Krupa et al.
In vertebrates, vitamin A (VA) is crucial for development, tissue homeostasis, vision, and immunity. Retinal, a form of VA, can be produced via enzymatic cleavage of β-carotene by beta-carotene oxygenase 1 (bco1) and bco1-like (bco1l), but...
Kar4 acts as a Ste12 regulator in Saccharomyces cerevisiae, promoting Ste12 binding to a specific DNA motif genome-wide [0.03%]
酿酒酵母中的Kar4通过调节Ste12的功能促进其与特定DNA基序结合
Jason V Rogers,Amanda Yeo,Val Meleshkevich et al.
Jason V Rogers et al.
Transcription factors must often transcribe different genes under different conditions. To achieve this, DNA-binding specificity is often constrained by binding to cofactors or other transcription factors. Kar4 is a putative transcription f...
Overdominance for fitness: A genomic comparison between empirical and simulated data with Drosophila melanogaster [0.03%]
适应性的超显性：果蝇(Drosophila melanogaster)实测基因组与模拟基因组的比较研究
Inés González-Castellano,Humberto Quesada,Sebastián Ramos-Onsins et al.
Inés González-Castellano et al.
Overdominance (heterozygote advantage) for fitness is a form of balancing selection which supports the maintenance of genetic polymorphisms in the populations. This mode of selection is expected to generate a conspicuous footprint on neutra...