Measuring linkage disequilibrium and improvement of pruning and clumping in structured populations [0.03%]
结构种群中连锁不平衡的度量以及剪枝和聚类的改进
Ulises Bercovich,Malthe Sebro Rasmussen,Zilong Li et al.
Ulises Bercovich et al.
Standard measures of linkage disequilibrium (LD) are affected by admixture and population structure, such that loci that are not in LD within each ancestral population appear linked when considered jointly across the populations. The influe...
Chaperone dysfunction in motor neuron disease: new insights from studies of the SMN complex [0.03%]
运动神经元疾病中辅助蛋白功能障碍：来自SMN复合物研究的新见解
A Gregory Matera
A Gregory Matera
Spinal muscular atrophy and amyotrophic lateral sclerosis are devastating neurodegenerative diseases characterized by motor neuron loss. Although these 2 disorders have distinct genetic origins, recent studies suggest that they share common...
Correction to: Knockdown of NeuroD2 leads to seizure-like behavior, brain neuronal hyperactivity and a leaky blood-brain barrier in a Xenopus laevis tadpole model of DEE72 [0.03%]
Correction to：DEE72 模型斑马鱼中神经元抑制导致类似癫痫的行为、大脑神经元高活性和功能障碍的血脑屏障
Published Erratum
Genetics. 2025 Feb 4:iyaf010. DOI:10.1093/genetics/iyaf010 2025
Yvonne M Bradford,Ceri E Van Slyke,Jonathan B Muyskens et al.
Yvonne M Bradford et al.
The Zebrafish Information Network (ZFIN, zfin.org) is the database resource for genetic, genomic, and phenotypic data from research using zebrafish, Danio rerio. ZFIN curates information about genetic perturbations, gene expression, phenoty...
An orphan gene is essential for efficient sperm entry into eggs in Drosophila melanogaster [0.03%]
一个孤儿基因对于黑腹果蝇精卵高效受精过程是必不可少的
Sara Y Guay,Prajal H Patel,Jonathon M Thomalla et al.
Sara Y Guay et al.
While spermatogenesis has been extensively characterized in the Drosophila melanogaster model system, very little is known about the genes required for fly sperm entry into eggs. We identified a lineage-specific gene, which we named katheri...
A Bayesian Approach to Correcting the Attenuation Bias of Regression Using Polygenic Risk Score [0.03%]
矫正回归中使用多基因风险评分的衰减偏差的一种贝叶斯方法
Geyu Zhou,Xinyue Qie,Hongyu Zhao
Geyu Zhou
Polygenic risk score (PRS) has become increasingly popular for predicting the value of complex traits. In many settings, PRS is used as a covariate in regression analysis to study the association between different phenotypes. However, measu...
The Rac1 homolog CED-10 is a component of the MES-1/SRC-1 pathway for asymmetric division of the C. elegans EMS blastomere [0.03%]
同源基因Rac-1 CED-10是控制线虫EMS卵裂细胞不对称分裂的MES-1/SRC-1途径的组成部分
Helen Lamb,McKenzi Fernholz,Małgorzata J Liro et al.
Helen Lamb et al.
Asymmetric cell division is essential for the creation of cell types with different identities and functions. The EMS blastomere of the four-cell Caenorhabditis elegans embryo undergoes an asymmetric division in response to partially redund...
Targeted seed EMS mutagenesis reveals a bHLH transcription factor underlying male sterility in sorghum [0.03%]
目标诱导大刍草突变体文库鉴定出控制高丹草雄性不育的转录因子基因
Yuguo Xiao,Rajdeep S Khangura,Zhonghui Wang et al.
Yuguo Xiao et al.
Forward genetic screens of mutant populations are fundamental for functional genomics studies. However, isolating independent mutant alleles to molecularly identify causal genes is challenging in species recalcitrant to genetic manipulation...
Activated SKN-1 alters the aging trajectories of long-lived C. elegans mutants [0.03%]
活化的SKN-1改变长寿线虫突变体的衰老轨迹
Chris D Turner,Sean P Curran
Chris D Turner
In the presence of stressful environments, the SKN-1 cytoprotective transcription factor is activated to induce the expression of gene targets that can restore homeostasis. However, chronic activation of SKN-1 results in diminished health a...