Heritability of DNA methylation in threespine stickleback (Gasterosteus aculeatus) [0.03%]
三刺鱼(DNA甲基化遗传性)
Juntao Hu,Sara J S Wuitchik,Tegan N Barry et al.
Juntao Hu et al.
Epigenetic mechanisms underlying phenotypic change are hypothesized to contribute to population persistence and adaptation in the face of environmental change. To date, few studies have explored the heritability of intergenerationally stabl...
Pan cancer patterns of allelic imbalance from chromosomal alterations in 33 tumor types [0.03%]
33种肿瘤类型中染色体改变引起的全癌种的等位基因不平衡模式
Smruthy Sivakumar,F Anthony San Lucas,Yasminka A Jakubek et al.
Smruthy Sivakumar et al.
Somatic copy number alterations (SCNAs) serve as hallmarks of tumorigenesis and often result in deviations from one-to-one allelic ratios at heterozygous loci, leading to allelic imbalance (AI). The Cancer Genome Atlas (TCGA) reports SCNAs ...
Effects of the domestic thyroid stimulating hormone receptor (TSHR) variant on the hypothalamic-pituitary-thyroid axis and behavior in chicken [0.03%]
鸡甲状腺刺激素受体(TSHR)变异对下丘脑-垂体-甲状腺轴及行为的影响
Amir Fallahshahroudi,Martin Johnsson,Enrico Sorato et al.
Amir Fallahshahroudi et al.
Domestic chickens are less fearful, have a faster sexual development, grow bigger, and lay more eggs than their primary ancestor, the red junglefowl. Several candidate genetic variants selected during domestication have been identified, but...
Regulation of growth and cell fate during tissue regeneration by the two SWI/SNF chromatin-remodeling complexes of Drosophila [0.03%]
SWI/SNF染色质重塑复合物通过调控组织再生过程中的细胞生长和命运决定参与果蝇发育
Yuan Tian,Rachel K Smith-Bolton
Yuan Tian
To regenerate, damaged tissue must heal the wound, regrow to the proper size, replace the correct cell types, and return to the normal gene-expression program. However, the mechanisms that temporally and spatially control the activation or ...
Proper CycE-Cdk2 activity in endocycling tissues requires regulation of the cyclin-dependent kinase inhibitor Dacapo by dE2F1b in Drosophila [0.03%]
Drosophila中dE2F1b调节cyclin依赖性激酶抑制因子Dacapo以使终型倍性细胞中CycE-Cdk2活性达到适宜水平
Minhee Kim,Keemo Delos Santos,Nam-Sung Moon
Minhee Kim
Polyploidy is an integral part of development and is associated with cellular stress, aging, and pathological conditions. The endocycle, comprised of successive rounds of G and S phases without mitosis, is widely employed to produce polyplo...
Protein quality control degron-containing substrates are differentially targeted in the cytoplasm and nucleus by ubiquitin ligases [0.03%]
泛素连接酶通过不同的胞质和核靶向途径降解包含蛋白质量控制degron的底物蛋白质
Christopher M Hickey,Carolyn Breckel,Mengwen Zhang et al.
Christopher M Hickey et al.
Intracellular proteolysis by the ubiquitin-proteasome system regulates numerous processes and contributes to protein quality control (PQC) in all eukaryotes. Covalent attachment of ubiquitin to other proteins is specified by the many ubiqui...
Genetic contribution to high temperature tolerance in Cryptococcus neoformans [0.03%]
新生隐球菌高温耐受性的遗传贡献研究
Piotr R Stempinski,Jessica M Zielinski,Nadir H Dbouk et al.
Piotr R Stempinski et al.
The human fungal pathogen Cryptococcus neoformans relies on a complex signaling network for the adaptation and survival at the host temperature. Protein phosphatase calcineurin is central to proliferation at 37°C but its exact contribution...
Deepash Kothiwal,Swagathnath Gopinath,Shikha Laloraya
Deepash Kothiwal
Cohesin is a conserved chromatin-binding multisubunit protein complex involved in diverse chromosomal transactions such as sister-chromatid cohesion, chromosome condensation, regulation of gene expression, DNA replication, and repair. While...
Characterizing the genetic basis of copper toxicity in Drosophila reveals a complex pattern of allelic, regulatory, and behavioral variation [0.03%]
揭示果蝇铜毒性的遗传基础呈现出了复杂的等位基因、调控和行为模式
Elizabeth R Everman,Kristen M Cloud-Richardson,Stuart J Macdonald
Elizabeth R Everman
A range of heavy metals are required for normal cell function and homeostasis. However, the anthropogenic release of metal compounds into soil and water sources presents a pervasive health threat. Copper is one of many heavy metals that neg...
Carl Mackintosh,Andrew Pomiankowski,Michael F Scott
Carl Mackintosh
X-linked meiotic drivers cause X-bearing sperm to be produced in excess by male carriers, leading to female-biased sex ratios. Here, we find general conditions for the spread and fixation of X-linked alleles. Our conditions show that the sp...