Jupiter Algorta,Ali Fele-Paranj,Jack M Hughes et al.
Jupiter Algorta et al.
We survey a combination of classical and recent experimental and modeling developments in eukaryotic cell migration, from the subcellular processes and regulation, to single and collective cell dynamics. We showcase several examples that de...
Bringing Chandelier Cells Out of the Shadows: Exploring the Development of a Unique Neuron Type in the Brain [0.03%]
揭秘吊灯细胞：探索大脑中一种独特神经元类型的发展历程
Clara Lenherr,Guilherme Neves,Marcio Guiomar de Oliveira et al.
Clara Lenherr et al.
Chandelier cells (ChCs) represent a unique GABAergic interneuron in the cortex, yet our knowledge of this sparsely populated cell type has remained equally sparse for many years. New tools, however, have brought ChCs out of the shadows, she...
Zala Sekne,Patryk Ludzia,Sebastian Balch et al.
Zala Sekne et al.
Telomerase ribonucleoprotein (RNP) plays a crucial role in maintaining telomere length by processively adding telomeric repeats to the 3' ends of chromosomes. Telomerase activation is linked to cancer, while mutations that compromise telome...
Lu Chen,Luis Francisco Zirnberger Batista
Lu Chen
Telomerase is a large ribonucleoprotein complex responsible for the addition of telomeric DNA repeats to chromosomal ends. Telomerase is composed of core and accessory components that work in coordination to ensure telomere length is mainta...
Shedding Light on Telomere Replication, Insights from the Fission Yeast Schizosaccharomyces pombe [0.03%]
从裂殖酵母Schizosaccharomyces pombe获得的端粒复制新见解
Stéphane Coulon
Stéphane Coulon
Over the years, the fission yeast has become a reference model for telomere biology studies as this organism shares with mammals a highly conserved telomere composition. Here, we highlight the latest discoveries in telomere replication in f...
Therapeutic Opportunities for Alternative Lengthening of Telomeres (ALT) Cancers [0.03%]
针对端粒选择性延长（ALT）癌症的治疗机会
Jixuan Gao,Hilda A Pickett
Jixuan Gao
Cancers that rely on activation of the alternative lengthening of telomeres (ALT) pathway predominantly affect children and adolescents, and are associated with catastrophic outcomes due to a lack of clinically effective, targeted therapeut...
Telomeres and Human Disease [0.03%]
端粒与人类疾病
Sharon A Savage
Sharon A Savage
Telomeres, the long nucleotide repeats, and protein complex at chromosome ends, are central to genomic integrity. Telomere length (TL) varies widely between populations due to germline genetics, environmental exposures, and other factors. V...
Nicole Bettin,Mélina Vaurs,Anabelle Decottignies
Nicole Bettin
Human telomeric heterochromatin is unusual in that it does not show the enrichment of canonical repressive histone marks H3K9me3 or H4K20me3 seen in constitutive heterochromatin. Instead, human telomeres exhibit both facultative heterochrom...
Telomeric Repeat-Containing RNA: Biogenesis, Regulation, and Functions [0.03%]
含有端粒重复序列的RNA：生物合成、调控和功能
Patricia L Abreu,Valentina Riva,Luca Zardoni et al.
Patricia L Abreu et al.
Telomeric repeat-containing RNA (TERRA) molecules are transcripts comprising extended stretches of telomeric G-rich repeats, which are generated from telomeres or intrachromosomal loci. TERRA production is an evolutionarily conserved proces...
Proteins of the Triadic Excitation-Contraction Coupling Complex in Skeletal Muscle [0.03%]
骨骼肌三联体兴奋-收缩耦联复合体中的蛋白质
Ting Chang,Rachel Sue Zhen Yee,George G Rodney et al.
Ting Chang et al.
Excitation-contraction coupling (ECC) in skeletal muscle is mediated by mechanical coupling between the L-type voltage-dependent Ca2+ channel (CaV1.1) in the transverse tubules and the Ca2+ release channel (RYR1) in the sarcoplasmic reticul...