Marie E Esper,John Saber,Michael A Rudnicki
Marie E Esper
Skeletal muscle owes its plasticity and ability to regenerate following severe injury to the resident somatic stem cells, termed satellite cells, of which a subset represent multipotent muscle stem cells (MuSCs). Adult MuSCs originate from ...
Joe Nassour,Jan Karlseder
Joe Nassour
Somatic mutations arise in normal tissues and precursor lesions, often targeting cancer-driver genes involved in cell cycle regulation. Most checkpoint-mutant clones, however, remain dormant throughout an individual's lifetime and seldom pr...
A History of Cancer Research: G1/S Transition and the Retinoblastoma Pathway [0.03%]
癌症研究史：G1/S转换和视网膜母细胞瘤通路
Joseph Lipsick
Joseph Lipsick
Basic research that established how the cell cycle is regulated has been critical to our understanding of carcinogenesis and paved the way for new treatments like palbociclib and ribocilib. Mitosis was first observed almost 150 years ago, a...
Julius Lukeš,Zuzana Čapková Pavlíková,Vyacheslav Yurchenko et al.
Julius Lukeš et al.
The standard genetic code, which applies almost without exception, is the key to our understanding of molecular biological processes. Although it is close to impossible to imagine that sparse code changes occur naturally given proteomic con...
Anna McGrane,Michael Murray,Fiona Bartoli et al.
Anna McGrane et al.
The PIEZO1 and PIEZO2 membrane proteins form uniquely structured calcium permeable nonselective cation channels dedicated to mechanical force sensing in eukaryotic cells. In this review of the scientific literature, we address PIEZOs in the...
Collaboration of Antipodes: Synergy of Branched and Linear F-Actin during Amoeboid Cell Movement and Chemotaxis [0.03%]
合则双赢：分支与线性F肌动蛋白在变形虫样细胞运动及趋化中的协同作用
Peter J M van Haastert,Arjan Kortholt
Peter J M van Haastert
The actin cytoskeleton plays a major role in locomotion of amoeboid cells. The extending pseudopod contains predominantly branched F-actin nucleated by actin-related protein 2/3 (Arp2/3) that is oriented toward the membrane, while the side/...
Yansong Lu,Avnika A Ruparelia,Peter D Currie
Yansong Lu
Recent technological advances in genome editing capabilities and live imaging capacities have greatly increased the use of the zebrafish model in skeletal muscle research, leading to critical discoveries in the cellular and molecular proces...
Joseph Lipsick
Joseph Lipsick
The RAS oncogene is a crucial driver of a number of cancers. The GTPase it encodes links growth factor receptors with signaling pathways that control cell proliferation. Activating mutations in RAS deregulate these pathways, promoting tumor...
Engineered In Vitro Platforms for Mechanochemical Control of Cell Migration [0.03%]
用于细胞迁移的机械化学控制的工程体外平台
Bishwa Ranjan Si,Qinling Yuan,Sanjiban Nath et al.
Bishwa Ranjan Si et al.
Cell migration in confined environments follows distinct mechanisms compared to conventional 2D migration. By using in vitro models and incorporating extracellular cues from the tissue microenvironment, we can gain deeper insights into the ...
Dong Li,Hui Tu,Huaqing Cai
Dong Li
Cell migration plays a central role in a wide range of physiological, developmental, and disease-related processes. Studies using single-cell models, such as Dictyostelium discoideum, have provided important insights into the molecular prin...