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Collaboration of Antipodes: Synergy of Branched and Linear F-Actin during Amoeboid Cell Movement and Chemotaxis

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The actin cytoskeleton plays a major role in locomotion of amoeboid cells. The extending pseudopod contains predominantly branched F-actin nucleated by actin-related protein 2/3 (Arp2/3) that is oriented toward the membrane, while the side/back of the cell con... ...