Control of Inositol 1,4,5-Trisphosphate Receptor Activity by Posttranslational Modifications [0.03%]
鸟氨酸脱羧酶的结构基础及其与底物和产物的相互作用
Maarten Vanmunster,Ian de Ridder,Manon Callens et al.
Maarten Vanmunster et al.
Inositol 1,4,5-trisphosphate receptors (IP3Rs) are tetrameric calcium (Ca2+) release channels localized in the endoplasmic reticulum (ER), where they regulate cellular function by mediating local and global Ca2+ fluxes toward the cytosol, c...
Collective Mesoderm and Endoderm Cell Migration during Vertebrate Gastrulation [0.03%]
脊椎动物原肠运动时期的中胚层和内胚层细胞迁移
Cornelis J Weijer
Cornelis J Weijer
Collective migration is a key mechanism during embryonic development, particularly during gastrulation when the basic three-dimensional body plan is established. During this critical phase, mesoderm and endoderm tissues internalize from the...
Telomeres and Telomerase [0.03%]
端粒与端粒酶
Julia Promisel Cooper,Eros Lazzerini Denchi,Joachim Lingner et al.
Julia Promisel Cooper et al.
Telomeres represent a molecular nexus where genome stability, aging, disease susceptibility, and regenerative potential converge. Advances in understanding how telomeres are replicated, protected, and repaired now inform fundamental questio...
Guiding Cells with Light and Chemicals: A Toolbox for Dynamic Studies of Cell Migration [0.03%]
用光和化学物质引导细胞：动态研究细胞迁移的工具箱
Abhijit Deb Roy,Elmer Rho,Takanari Inoue
Abhijit Deb Roy
Cell migration is a fundamental biological process central to a number of physiological and pathophysiological events. Traditional genetic and pharmacological approaches have identified crucial molecular regulators of migration, yet they of...
Chromosome Ends in Motion: Telomeres as Hazards and Hubs in Meiosis [0.03%]
运动着的染色体末端：减数分裂中端粒作为危险和中心的作用
Rahul Thadani,Noah Johnson,Julia Promisel Cooper
Rahul Thadani
Beyond their well-known roles in chromosome end protection, telomeres play critical roles in ensuring the fidelity of meiosis, the specialized cell division underlying sexual reproduction. Central to this process is the conserved telomere b...
Running to Their Fates: Neural Crest and Placode Migratory Behavior and Cell Fate Decisions [0.03%]
命运般的奔跑：神经嵴和胎盘体的迁移行为及细胞命运决定
Junpeng Gao,Hugo A Urrutia,Marianne E Bronner
Junpeng Gao
Neural crest cells are among the most migratory cells in the vertebrate embryo. They initially arise within the forming neural tube, the precursor to the brain and spinal cord, but then migrate away by undergoing an epithelial-to-mesenchyma...
Danai Laskaratou,Olivia Olislaegers,Hideaki Mizuno
Danai Laskaratou
Cytosolic Ca2+ plays a crucial role as a second messenger in cell signaling, regulating a wide range of cellular processes. Hence, studying its spatiotemporal dynamics has emerged as a key area of research, and fluorescence imaging has beco...
David R Eberhardt,Dipayan Chaudhuri
David R Eberhardt
Calcium (Ca2+) is vital in hepatocyte metabolism and plays a dual role in liver mitochondrial function: Physiological Ca2+ stimulates respiration and mitochondrial dynamics-processes crucial for proper metabolic functioning. However, Ca2+ o...
Endothelial CRAC Channels [0.03%]
内皮细胞CRAC通道
Olivier Romito,Mohamed Trebak
Olivier Romito
Store-operated Ca2+ entry (SOCE) is the primary Ca2+ entry mechanism in nonexcitable cells such as endothelial cells (ECs). When the endoplasmic reticulum (ER)-resident stromal-interacting molecules 1 and 2 (STIM1/2) sense the depletion of ...
Calcium Tunneling: A Pervasive Signaling Module Mediated by Coupling Store-Operated Ca2+ Entry and Endoplasmic Reticulum Ca2+ Release [0.03%]
钙隧穿：一种通过偶联内质网钙释放和钙库操作的钙内流介导的普遍存在的信号模块
Raphael Courjaret,Khaled Machaca
Raphael Courjaret
The ability of the cell to generate precise and sustained intracellular Ca2+ signals is governed by multiple spatial and temporal restrictions. Ca2+ flowing into the cell through plasma membrane channels activates multiple effectors but is ...