Evaluating Powder Deposition in the Nasal Airways Using a Facile Fluorescent-Imaging Method [0.03%]
利用简便的荧光成像法评估鼻腔气道中的粉末沉积量
William Hunter,Kiao Inthavong,Sara Vahaji et al.
William Hunter et al.
Background: Intranasal drug delivery is a critical route for both systemic and targeted therapies, particularly for drugs intended to reach the central nervous system via the olfactory region. However, current aqueous nasal sprays have limi...
Preclinical Development of a Dry Powder Formulation of Loxapine for Intranasal Delivery [0.03%]
洛沙平鼻用粉雾剂的药物研发前期工作
Paul Shields,Irene Rossi,Daniela Schwotzer et al.
Paul Shields et al.
Background: Acute agitation (AA) is a common symptom of psychiatric conditions such as bipolar disorder and schizophrenia, resulting in 1.7 million emergency room visits per year in the United States. Loxapine, administer...
Letter: Impact of Suboptimal Peak Inspiratory Flow on Exacerbations in Chronic Obstructive Pulmonary Disease Patients Using Dry Powder Inhalers [0.03%]
信件：慢性阻塞性肺病患者使用干粉吸入器峰呼气流速不佳对急性加重的影响
Ji-Yong Moon,Sang Hyuk Kim,Youlim Kim et al.
Ji-Yong Moon et al.
Mucociliary Clearance Following a Next-Generation Propellant Versus Hydrofluoroalkane-134a via Pressurized Metered-Dose Inhaler: A Randomized, Double-Blind, Two-Way Crossover Study in Healthy Adults [0.03%]
新型推进剂与氢氟烷-134A压力定量气雾剂给药后对健康成人粘液纤毛清除功能的影响：一项随机、双盲、两周期交叉研究
Scott H Donaldson,Kirby L Zeman,Alan Bell et al.
Scott H Donaldson et al.
Background: Pressurized metered-dose inhalers (pMDIs) are commonly used for respiratory disease treatment but contain propellants, such as hydrofluoroalkane-134a (HFA-134a), with global warming potential (GWP) that contri...
Toward Next-Generation Propellants: Assessing Lung Deposition of Beclometasone Dipropionate, Formoterol, and Glycopyrrolate Formulated with HFA-152a Using Functional Respiratory Imaging [0.03%]
新一代推进剂的研究：使用功能性呼吸道影像法评估HFA-152a配制的倍氯米松、福莫特罗和甘羟铝的肺部沉积率
Angelo Matturro,Navid Monshi Tousi,Hosein Sadafi et al.
Angelo Matturro et al.
Background: Pressurized metered-dose inhalers (pMDIs) rely on hydrofluoroalkane (HFA) propellants that have a high global warming potential (GWP). Reformulation with next-generation, low-GWP propellants, such as HFA-152a,...
Safety and Pharmacokinetic Data for Inhaled Administration of Nintedanib Dry Powder Inhalation for Treatment of Pulmonary Fibrotic Diseases [0.03%]
用于治疗肺纤维化疾病的尼达尼布干粉吸入剂给药的安全性及药代动力学数据
Wassim H Fares,Michael Castagna
Wassim H Fares
Background: Idiopathic pulmonary fibrosis (IPF) is an incurable disease marked by irreversible fibrosis and declining respiratory function. Nintedanib inhalation powder is a novel dry powder inhalation formulation of nint...
Selecting the Optimal Inhaler in Asthma: Respiratory and Peripheral Muscle Strength as Predictors of DPI and MDI Response [0.03%]
选择哮喘的最优吸入剂：呼吸和外周肌肉力量作为DPI和MDI反应预测指标
Buğra Kerget,Alperen Aksakal,Sırma Merve Çetin et al.
Buğra Kerget et al.
Background: Asthma is characterized by variable airway obstruction, and proper inhaler choice and use are critical for effective treatment. This study aimed to identify factors influencing treatment response in newly diag...
Usability of Levodopa Cyclops® Compared to INBRIJA® During an off Episode in Parkinson's Disease Patients [0.03%]
左旋多巴环形片(Levocopa®)与INBRIJA®在帕金森病(off期)患者中的疗效比较研究
Valesca Wangsawirana,Lara de Jong,Annebet van der Meulen et al.
Valesca Wangsawirana et al.
Background: This study compares the usability of two levodopa dry powder inhalers. The Inbrija® inhaler involves several preparatory steps, including blister opening and capsule insertion. The Cyclops® inhaler is preloa...
Jeffry G Weers,Thomas E Tarara,Danforth P Miller
Jeffry G Weers
Regional deposition of inhaled medicines in the respiratory tract is heavily influenced by inertial impaction. Despite this, the current convention is to convert impaction parameter cutoffs on stages in impactors to size cutoffs by operatin...
Design of Dry Powder Inhalers: 2. The Impact of Suboptimal Peak Inspiratory Flow Rates on Bronchodilation in Patients with Obstructive Lung Diseases [0.03%]
干粉吸入剂的设计（二）： suboptimal peak inspiratory flow rates对阻塞性肺疾病患者支气管舒张的影响
Jeffry G Weers,Thomas E Tarara,Danforth P Miller
Jeffry G Weers
Background: Suboptimal peak inspiratory flow rate (sPIFR) has been proposed as a biomarker of disease progression in people with chronic obstructive pulmonary disease (COPD). Furthermore, sPIFR has been claimed to result ...