Jeffry G Weers,Thomas E Tarara,Danforth P Miller
Jeffry G Weers
Regional deposition of inhaled medicines in the respiratory tract is heavily influenced by inertial impaction. Despite this, the current convention is to convert impaction parameter cutoffs on stages in impactors to size cutoffs by operatin...
Design of Dry Powder Inhalers: 2. The Impact of Suboptimal Peak Inspiratory Flow Rates on Bronchodilation in Patients with Obstructive Lung Diseases [0.03%]
干粉吸入剂的设计（二）： suboptimal peak inspiratory flow rates对阻塞性肺疾病患者支气管舒张的影响
Jeffry G Weers,Thomas E Tarara,Danforth P Miller
Jeffry G Weers
Background: Suboptimal peak inspiratory flow rate (sPIFR) has been proposed as a biomarker of disease progression in people with chronic obstructive pulmonary disease (COPD). Furthermore, sPIFR has been claimed to result ...
Inhaler Adherence and Treatment Behaviors in COPD: A Study from Both Sides of the Aegean Sea [0.03%]
来自爱琴海两岸慢阻肺患者的吸入器依从性及治疗行为研究
Onur Turan,Andriana Papaioannou,Nalan Ogan et al.
Onur Turan et al.
Background: Patient adherence is a key factor in the effectiveness of chronic obstructive pulmonary disease (COPD) treatment. The Test of Adherence to Inhalers (TAI-12) scoring system, which evaluates adherence in patient...
Formulation and Development of Spray-Dried Atorvastatin Nanoparticles for Potential Antifungal Applications [0.03%]
用于潜在抗真菌应用的阿托伐他汀纳米颗粒喷雾干燥配方及开发
Fai Alkathiri,Njoud Altuwaijr,Rihaf Alfaraj et al.
Fai Alkathiri et al.
Background: Atorvastatin (ATR), traditionally prescribed as an antihyperlipidemic agent, has shown promising therapeutic potential beyond its primary indication, including anti-inflammatory, antioxidant, and antifungal pr...
Identification of an Inhaled Pulmonary Selective PDGFR Inhibitor with Sustained Target Engagement [0.03%]
一种具有持续靶点作用的吸入性肺选择性PDGFR抑制剂的鉴定
Glenn Marsboom,Tianbao Lu,Zhigang Hong et al.
Glenn Marsboom et al.
Background: Inhalation of corticosteroids, bronchodilators, antivirals, and antibiotics is well established to treat a variety of pulmonary diseases; however, no inhaled receptor tyrosine kinase (RTK) inhibitors have so f...
Daryl L Roberts
Daryl L Roberts
Background: International compendia specify setting the flow for testing dry powder inhalers (DPIs) with the pressure ratio across the flow control valve ≤0.5. This guidance derives from thermodynamic theory, but there i...
Advances in the Application of Additive Manufacturing in Respiratory Inhalation Therapy [0.03%]
增材制造在呼吸吸入治疗中的应用进展
Chao Zhang,Xinyu Zhang,Junhui Zhang et al.
Chao Zhang et al.
Inhalation therapy has become a cornerstone in the treatment of respiratory diseases such as asthma, chronic obstructive pulmonary disease, and cystic fibrosis, owing to its rapid onset, direct pulmonary targeting, and avoidance of first-pa...
Digital Image Segmentation Analysis Enables High-Throughput Next-Generation Impactor Analysis [0.03%]
数字图像分割分析可实现下一代撞击器的高通量分析
Jaston McClure,Daniel Dobson,Ed Yost et al.
Jaston McClure et al.
Purpose: Aerodynamic particle size distribution (APSD) determination is a key quality attribute for inhaled therapeutics. The next-generation impactor is the gold standard for APSD determination; however, it suffers from ...
Yusuf Aydemir,Sahinur Aycan Alkan,Damla Serçe Unat et al.
Yusuf Aydemir et al.
Background/aim: In the treatment of respiratory diseases, the skill and adherence to inhaler device use are very important. Therefore, frequent replacements of devices that patients are accustomed to are not recommended d...