Suhani B Bhakta,Yi-Wei Chen
Suhani B Bhakta
Fusobacterium nucleatum is a Gram-negative bacterium that plays a central role in biofilm formation within the oral cavity. While traditionally considered a commensal organism, accumulating evidence has implicated F. nucleatum in the pathog...
Modeling Fusobacterium nucleatum-Driven Colorectal Cancer in Apc-Mutant Mice [0.03%]
利用APC突变型小鼠模拟核梭杆菌驱动的结直肠癌
Bing Han,Wei Liu,Yimin Chen et al.
Bing Han et al.
Colorectal cancer (CRC) typically initiates with mutations in the adenomatous polyposis coli (Apc) gene, followed by the influence of environmental factors. Among these, Fusobacterium nucleatum has emerged as an important CRC-enriched micro...
A Murine Floor-of-Mouth Model for Investigation of Fusobacterium nucleatum-Associated Oral Squamous Cell Carcinoma [0.03%]
Pachiyappan Kamarajan,Allan Radaic,Yvonne L Hernandez-Kapila
Pachiyappan Kamarajan
Oral squamous cell carcinoma (OSCC) is the most prevalent malignancy of the oral cavity and a major subtype of head and neck squamous cell carcinoma (HNSCC). While established risk factors such as tobacco use, alcohol consumption, and human...
Mass Spectrometry-Based Untargeted Metabolite Profiling to Discover Molecular Consequences of Mammalian Cell Infection with Fusobacterium nucleatum [0.03%]
基于质量测定的非靶代谢产物分析发现Fusobacterium nucleatum感染哺乳动物细胞所产生的分子效应
Qiuying Chen,Huiyong Cheng,Steven S Gross
Qiuying Chen
Untargeted metabolite profiling, aka metabolomics, offers a powerful technology to potentially reveal fundamental molecular mechanisms whereby a perturbation in cell metabolism leads to an alteration in cell growth or physiological maintena...
Fluorescence and Electron Microscopy of Fusobacterium nucleatum-Induced Autophagy [0.03%]
荧光和电子显微镜下福斯杆菌诱导的自噬现象
Yimin Chen,Hung Ton-That
Yimin Chen
Fusobacterium nucleatum, an opportunistic oral anaerobe, has emerged as a key microbial contributor of colorectal cancer (CRC) progression and chemoresistance through its modulation of host cellular pathways. Autophagy-a conserved degradati...
An Asymmetric Gas Coculture System for Oral Pathobionts and Gingival Epithelial Cells [0.03%]
口腔病原体和牙龈上皮细胞的不对称气体共培养系统
Zeyang Pang,Collins I Chimezie,Amber E Haley et al.
Zeyang Pang et al.
Establishing a coculture system that models oral microbial-host interaction can be challenging. The oral cavity harbors a mixture of both anaerobic and aerobic bacteria and is subjected to alternating periods of rich oxygen exposure and oxy...
Isolation and Proteomic Characterization of Outer Membrane Vesicles in Fusobacterium nucleatum [0.03%]
溶血性链球菌外膜囊泡的分离及蛋白质组学分析
Jinjing Liu,Yung-Fu Chang
Jinjing Liu
Fusobacterium nucleatum is an anaerobic Gram-negative bacterium associated with periodontal disease and colorectal cancer. Outer membrane vesicles (OMVs) produced by F. nucleatum are nanoscale lipid vesicles enriched with immunogenic and vi...
Dana Franklin,Angela Agnew,John Crow et al.
Dana Franklin et al.
In Fusobacterium nucleatum, bacterial microcompartments (BMCs) are polyhedral organelles that encapsulate the catabolism of ethanolamine (EA), creating a specialized environment that protects the rest of the cell from toxic metabolic byprod...
Isolation of Primary RNA for Differential RNA Sequencing in Fusobacterium nucleatum [0.03%]
分离Fusobacterium nucleatum进行差异RNA测序的初始RNA
Falk Ponath,Jörg Vogel
Falk Ponath
Understanding gene expression in Fusobacterium nucleatum and related species is essential for uncovering the molecular mechanisms that underlie their adaption to various environments. However, the isolation of high-quality RNA from these Gr...
Ajay Kumar,Xuesong He
Ajay Kumar
In eukaryotic cells, small RNAs (sRNAs) are a class of noncoding RNAs that are less than 200 nucleotides in length and mainly classified per their biogenesis as microRNA, small interfering RNA, PIWI-interacting RNA (piRNA) or tRNA-derived s...