Reduction of Myocardial Infarct Size in the Rabbit by a Carbohydrate Analog of Sialyl Lewis(x) [0.03%]
碳水化合物类SialylLewis(x)类似物减少兔心肌梗死面积
KS Kilgore,JL Park,L Chi et al.
KS Kilgore et al.
BACKGROUND: Available data suggest that the accumulation of neutrophils within the myocardium following an ischemic event plays an important role in the pathogenesis of myocardial ischemia/reperfusion injury. It is of interest, therefore, t...
Electrophysiologic Effects of Beta-blocking Agent, Tilisolol, on Isolated Guinea Pig Ventricular Myocytes [0.03%]
β阻滞剂蒂西洛尔对分离的 Guinea 猪心室肌细胞电生理的影响
F Sakai,S Kawano,M Hiraoka
F Sakai
BACKGROUND: Electrophysiologic effects of a beta-blocking agent, tilisolol, were studied with isolated guinea pig ventricular myocytes using the whole cell patch clamp technique. METHODS AND RESULTS: Tilisolol at 10 µM or higher concentrat...
Protective Effect of Elastase Inhibition Against Myocardial Dysfunction and Injury Induced by Ischemia and Reperfusion in Isolated Rat Hearts [0.03%]
弹性酶抑制对隔离大鼠心脏缺血再灌注诱导的心肌功能障碍和损伤的保护作用
BC Yang,JC Williams,JL Mehta
BC Yang
BACKGROUND: Elastase release has been incriminated in the genesis of reperfusion-induced myocardial dysfunction and injury, and elastase inhibitors have been reported to reduce myocardial dysfunction in dogs subjected to coronary artery occ...
A Randomized Multicenter Trial Comparing and Efficacy of Simvastatin and Fluvastatin [0.03%]
辛伐他汀和氟伐他汀疗效的多中心随机对照试验
DR Illingworth,EA Stein,RH Knopp et al.
DR Illingworth et al.
BACKGROUND: Inhibitors of hydroxymethylglutaryl co-enzyme A reductase are widely used for the treatment of hypercholesterolemia. Physicians and third-party payers need an accurate measure of their relative potency and hypolipidemic efficacy...
Investigative Concerns in Demonstrating Reduced Risk From Reversing Left Ventricular Hypertrophy [0.03%]
评估左心室肥厚逆转以证明降低风险的挑战性问题
ED Frohlich,D Aristizabal,F Soria et al.
ED Frohlich et al.
BACKGROUND: To demonstrate reduced risk from reversing left ventricular hypertrophy (LVH) in hypertension, one must show that it is independent of blood pressure reduction. METHODS AND RESULTS: A feasibility study was conducted with 15 pati...
Effects of Sotalol on His-Purkinje Conduction and Refractoriness in Humans [0.03%]
索他洛尔对人心肌房室结-希浦系统传导和不应期的影响
K Nademanee,HE Noll,GK Feld
K Nademanee
BACKGROUND: The effects of sotalol on refractoriness in human ventricular and atrial muscles have been well established, but the drug's effect on the electrical properties of the His-Purkinje system in humans is not known, especially whethe...