From Needle to Pill: Oral PCSK9 Inhibition Enters the Lipid-Lowering Armamentarium [0.03%]
从注射到口服：口服PCSK9抑制剂成为降脂新选择
Andrej Belancic,Josip Andelo Borovac
Andrej Belancic
Targeting Aldosterone Biosynthesis in Uncontrolled and Resistant Hypertension: A Systematic Review and Meta-Analysis of Randomized Trials of Lorundrostat and Baxdrostat [0.03%]
顽固性和难治性高血压醛固酮合成靶向治疗的系统评价和荟萃分析：罗普德拉斯特和巴克德拉斯特随机对照试验的系统综述和荟萃分析
Ravi Pandey,Muhammad Ahmad,Ali Rohan et al.
Ravi Pandey et al.
BackgroundAldosterone excess contributes to uncontrolled and resistant hypertension, making aldosterone synthase inhibition a promising therapeutic strategy. Recent randomized trials have evaluated the selective aldosterone synthase inhibit...
Effects of Vericiguat on Peripheral Vascular Function and Resting/Exercise Hemodynamics in Patients With Heart Failure With Reduced Ejection Fraction: An Exploratory Pilot Study [0.03%]
维卡格普对射血分数降低的心力衰竭患者外周血管功能和静息/运动血液动力学影响的探索性试点研究
Yohei Funauchi,Toru Takase,Kazuyoshi Kakehi et al.
Yohei Funauchi et al.
BackgroundVericiguat improves outcomes in heart failure with reduced ejection fraction (HFrEF), but its vascular and hemodynamic effects remain unclear. We explored changes in flow-mediated dilation (FMD) and invasive hemodynamics after ver...
Norepinephrine Versus Dopamine as Vasoactive Therapy in Cardiogenic Shock: Association With 28-Day Mortality in a Retrospective Cohort Study [0.03%]
儿茶酚胺性血管活性治疗在心源性休克中的应用：一项回顾性队列研究中与28天病死率的关系
Suthida Chanchenchop,Supanee Sinphurmsukskul,Krittin Bunditanukul
Suthida Chanchenchop
BackgroundCardiogenic shock remains a life-threatening condition with persistently high mortality. Norepinephrine and dopamine are commonly used vasoactive agents; however, comparative data on clinical outcomes remain limited.MethodsThis re...
ABCD-GENE Score and Bleeding in Post-PCI Patients: Implications for Guided De-Escalation of Antiplatelet Therapy [0.03%]
ABCD-基因评分与冠脉支架术后患者的出血事件：用于指导减少抗血小板治疗的依据
James C Coons,Kathleen Polkowski,Linda Prebehalla et al.
James C Coons et al.
BackgroundThe ABCD-GENE (Age, Body Mass Index, Chronic Kidney Disease, Diabetes Mellitus, and Genotyping) score is a tool used to identify increased thrombotic risk in clopidogrel-treated patients. We evaluated the association between a low...
Alterations of Platelet MicroRNAs Associated With Dapagliflozin Treatment in Individuals With Type 2 Diabetes Mellitus [0.03%]
达格列净治疗2型糖尿病患者血小板微RNA改变的研究
Feng Chen,Xueyan Ding,Feifei Dong et al.
Feng Chen et al.
BackgroundPlatelet hyperactivity contributes to elevated cardiovascular risk in type 2 diabetes mellitus (T2DM). Sodium-glucose cotransporter-2 inhibitors, including dapagliflozin, exert beneficial effects on platelet function and cardiovas...
Comparative Effectiveness of Renin-Angiotensin System Inhibitors in Heart Failure With Nonreduced Ejection Fraction: A Multicenter Cohort Study [0.03%]
射血分数保留的心力衰竭患者中血管紧张素系统抑制剂比较有效性的多中心队列研究
Ming-Shyan Lin,Po-Chang Wang,Jung-Jung Chang et al.
Ming-Shyan Lin et al.
BackgroundThe comparative effectiveness of angiotensin-converting enzyme inhibitors (ACEis) versus angiotensin receptor blockers (ARBs) in heart failure with nonreduced ejection fraction (HFnon-rEF) remains uncertain. We evaluated long-term...
Shared Genetic Liability Between Heart Failure and Myocardial Infarction Revealed by Genome-Wide Cross-Trait Analysis [0.03%]
基于全基因组跨性状分析揭示心力衰竭和心肌梗死间的共有遗传易感性
Ruikang Liu,Chiyun Sun,Nan Jiang et al.
Ruikang Liu et al.
BackgroundThe extent and biological relevance of shared genetic architecture between myocardial infarction (MI) and heart failure (HF) remain incompletely understood.MethodsWe analyzed large-scale European-ancestry genome-wide association s...
Multiomics Mendelian Randomization of GWAS, eQTL, and pQTL Combined With Drug Analysis to Predict Drug Targets in Myocardial Infarction [0.03%]
结合GWAS、eQTL和pQTL的多组学孟德尔随机化联合药物分析预测心肌梗死的药物靶点
Didi Yuan,Lian Hu,Yanqing Huang et al.
Didi Yuan et al.
Despite significant advances in the management of myocardial infarction (MI), therapeutic options targeting upstream pathogenic mechanisms remain scarce. This study introduces a novel multiomics-to-drug discovery framework to identify and v...