Knockdown of CXCL13 Improves Vascular Remodeling, Reduces Blood Pressure and Protects the Heart in a Hypertensive rat Model by Regulating the PF4V1/NF-κB Signaling Pathway [0.03%]
下调CXCL13通过调节PF4V1/NF-κB信号通路改善高血压大鼠血管重构、降低血压和保护心脏功能
Jie Ma,Xiaoguang Sun,Xianjun Hu
Jie Ma
BackgroundCardiovascular disease remains the first major reason for death in global, and hypertension is one very usual risk factor for this disease. Chemokine (CXC motif) ligand 13 (CXCL13) exhibits a crucial role in the development and an...
Cardiovascular Therapeutic Applications of the Human Amnion: Membrane, Cells, and Beyond [0.03%]
人胎盘膜的心血管治疗应用：膜、细胞等
Ian Nickel,Grace Mitchell,Hadi Javan et al.
Ian Nickel et al.
BackgroundThe therapeutic potential of the human amnion has been known since the early twentieth century. Subsequent study has revealed the further therapeutic potential of all elements of the amnion-membrane, cells, fluid-in the treatment ...
Clinical Evaluation of QTc Interval Prolongation With the Dual Endothelin Receptor Antagonist Aprocitentan [0.03%]
双ETA受体拮抗剂阿普利生坦临床评价的QTc间期延长效应
P N Sidharta,J M Brussee,A Schultz et al.
P N Sidharta et al.
IntroductionAprocitentan, is an orally active, once-daily administered, dual endothelin receptor antagonist that was recently approved for the treatment of hypertension in combination with other antihypertensive drugs, to lower blood pressu...
LncRNA Sirt1-AS Protects Against Cardiac Hypertrophy by Modulating Sirt1 [0.03%]
长链非编码RNA Sirt1-AS通过调控Sirt1保护心脏免受肥厚影响
Xuejiao Wei,Chenrui Zhang,Shuanglong Mou et al.
Xuejiao Wei et al.
BackgroundLncRNAs are pivotal regulators in cardiovascular diseases. Sirt1-AS, a lncRNA, has been shown to play a role in cardiovascular diseases. This study aimed to explore the role of Sirt1-AS in cardiac hypertrophy and the underlying mo...
Inhibition of ANXA1 Ameliorates Myocardial Ischemia/Reperfusion Injury by Targeting RAS/Raf/MAPK Axis-Mediated Ferroptosis [0.03%]
annexin A1通过靶向RAS/Raf/MAPK轴介导的铁死亡来缓解心肌缺血再灌注损伤
Yin Guo,Tian-Xiao Lou,Yang Liu et al.
Yin Guo et al.
Objective: Annexin-A1 (ANXA1) participates in regulating ferroptosis. Ferroptosis is involved in myocardial ischemia-reperfusion injury (MIRI). However, effect and mechanism of ANXA1 in ferroptosis after MIRI remain unclear. Materials and M...
Administration of β-Nicotinamide Mononucleotide Attenuates Myocardial Dysfunction in Tail-Suspended Mice [0.03%]
β-烟酰胺单核苷酸缓解尾悬小鼠的心功能障碍
Wenyu Gu,Dan Liu,Lei Wei et al.
Wenyu Gu et al.
Microgravity conditions cause myocardial atrophy and dysfunction with limited therapeutics. Accumulating evidence demonstrates that the deficiency of nicotinamide adenine dinucleotide (NAD+) contributes to myocardial dysfunction under micro...
Clinical Efficacy of Canrenone in Restoring Sinus Rhythm in Patients With Atrial Fibrillation-A Pilot, Randomized, Double-Blind Study [0.03%]
卡伦酮复律房颤患者的临床疗效——一项随机双盲研究
Rafał Dąbrowski,Agnieszka Segiet-Święcicka,Stefan Sawicki et al.
Rafał Dąbrowski et al.
Background and aimsRenin-angiotensin-aldosterone system (RAAS) inhibition is an upstream therapy for managing atrial fibrillation (AF). Of all RAAS-inhibiting agents, only canrenone in the form of potassium canrenoate, a specific inhibitor ...
Randomized Controlled Trial
Journal of cardiovascular pharmacology and therapeutics. 2025 Jan-Dec:30:10742484251356361. DOI:10.1177/10742484251356361 2025
Clinical Efficacy of Atorvastatin and PCSK9 Inhibitors in Patients With Borderline Coronary Lesions: An Intravascular Ultrasound Assessment [0.03%]
阿托伐他汀与PCSK9抑制剂对临界性冠脉病变患者临床疗效的评价：一项血管内超声研究
Zeyu Xu,Yi Fang,Yong Peng et al.
Zeyu Xu et al.
BackgroundWhile PCSK9 inhibition has proven safe and effective, there is limited research on using intravascular ultrasound (IVUS) to assess the impact of atorvastatin combined with PCSK9 inhibitors on borderline coronary lesions.MethodsFro...
Randomized Controlled Trial
Journal of cardiovascular pharmacology and therapeutics. 2025 Jan-Dec:30:10742484251361059. DOI:10.1177/10742484251361059 2025
Knockdown of AMFR Alleviates Atrial Fibrosis in Atrial Fibrillation by Stabilizing SOD1 Protein Expression [0.03%]
AMFR敲低通过稳定SOD1蛋白表达缓解房颤中房室纤维化加重
Shanshan Geng,Zhongbao Ruan,Lianghong Ying et al.
Shanshan Geng et al.
PurposeDemonstration of the role of autocrine motility factor receptor (AMFR) in atrial fibrillation (AF) mice.MethodsThe AF model was established by administering Ang II to mice and transfected with AMFR knockdown or AMFR overexpression pl...