Up-Titration of Sacubitril/Valsartan Among Patients With Heart Failure and Preserved Ejection Fraction [0.03%]
具有射血分数保留的心力衰竭患者的沙库巴曲/缬沙坦剂量增加研究
Koichiro Matsumura,Takeshi Ijichi,Junko Morimoto et al.
Koichiro Matsumura et al.
Aims: In recent large trials, sacubitril/valsartan demonstrated favorable effects in patients with HF. However, many patients do not achieve the target dose of treatment. This study investigated the factors linked to up-t...
Rupert M Bauersachs
Rupert M Bauersachs
Fondaparinux sodium is a chemically synthesized selective factor Xa inhibitor approved for the prevention and treatment of venous thromboembolic events, that is, deep vein thrombosis, pulmonary embolism, and superficial vein thrombosis, in ...
Glucagon-Like Peptide-1 Receptor Agonists and Dual Glucose-Dependent Insulinotropic Polypeptide/Glucagon-Like Peptide-1 Receptor Agonists in the Treatment of Obesity/Metabolic Syndrome, Prediabetes/Diabetes and Non-Alcoholic Fatty Liver Disease-Current Evidence [0.03%]
胰高血糖素样肽-1受体激动剂和双葡萄糖依赖性促胰岛素多肽/胰高血糖素样肽-1受体激动剂在肥胖症/代谢综合征，糖尿病前期/糖尿病和非酒精性脂肪肝疾病的治疗中的作用-当前证据
Emir M Muzurović,Špela Volčanšek,Karin Zibar Tomšić et al.
Emir M Muzurović et al.
The obesity pandemic is accompanied by increased risk of developing metabolic syndrome (MetS) and related conditions: non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH), type 2 diabetes mellitus (T2DM) and cardio...
James C Coons,James M Stevenson,Ami Patel et al.
James C Coons et al.
Purpose: The impact of antiplatelet therapy with availability of CYP2C19 genotyping on bleeding in a real-world setting has not been extensively studied. ...
Prescribing Patterns of Direct-Acting Oral Anticoagulants in Patients With Atrial Fibrillation and Chronic Kidney Disease: A Retrospective Cohort Analysis [0.03%]
房颤和慢性肾病患者直接口服抗凝剂的处方规律：一项回顾性队列分析
Jorge L Reyes,Charles A Herzog,Heng Yan et al.
Jorge L Reyes et al.
Background: The association of patient and prescriber characteristics with use of warfarin versus direct-acting oral anticoagulants (DOACs) in patients with atrial fibrillation (AF) and chronic kidney disease (CKD) is not...
A Phase 3 Randomized Controlled Trial to Evaluate Efficacy and Safety of New-Formulation Zenon (Rosuvastatin/Ezetimibe Fixed-Dose Combination) in Primary Hypercholesterolemia Inadequately Controlled by Statins [0.03%]
评价新制剂Zenon(瑞舒伐他汀/依折麦布固定剂量联合用药)在随机对照试验中对仅用他汀类药物不能充分控制的原发性高胆固醇血症的疗效和安全性第三阶段临床试验
Alberico L Catapano,Michal Vrablik,Yuri Karpov et al.
Alberico L Catapano et al.
Objective: In primary hypercholesterolemia many people treated with statins do not reach their plasma LDL-C goals and are at increased risk of cardiovascular disease (CVD). This study aimed to evaluate efficacy and safety...
Association of Valproic Acid Use With Post-Myocardial Infarction Heart Failure Development: A Meta-Analysis of Two Retrospective Case-Control Studies [0.03%]
丙戊酸使用与心肌梗死后心力衰竭发生的关联：对两项回顾性病例对照研究的荟萃分析
Joseph D English,Shuo Tian,Zhong Wang et al.
Joseph D English et al.
Background: Despite advances in treatments, myocardial infarction (MI) remains a significant cause of morbidity and mortality worldwide. Our team has previously shown that valproic acid (VPA) is cardio-protective when adm...
Direct Ischemic Postconditioning After Carotid Endarterectomy in the Prevention of Postoperative Cerebral Ischemic Complications-Observational Case-Control Study [0.03%]
颈动脉内膜剥脱术后直接缺血后处理在预防术后脑缺血并发症中的作用-观察性病例对照研究
Nenad Ilijevski,Igor Atanasijević,Branko Lozuk et al.
Nenad Ilijevski et al.
Introduction: Ischemic postconditioning (IPCT) represents one of the several therapeutic strategies to attenuate ischemic reperfusion injury (IR) after carotid endarterectomy (CEA). We here present the first in-human stud...
Evaluation of Risk Factors Associated With Antihypertensive Treatment Success Employing Data Mining Techniques [0.03%]
运用数据挖掘技术评估抗高血压治疗成功的风险因素及其评价
Selçuk Şen,Denizhan Demirkol,Mert Kaşkal et al.
Selçuk Şen et al.
Objective: This study aimed to evaluate the effects of potential risk factors on antihypertensive treatment success. Methods: Patients ...
CSL112 (Apolipoprotein A-I [Human]) Strongly Enhances Plasma Apoa-I and Cholesterol Efflux Capacity in Post-Acute Myocardial Infarction Patients: A PK/PD Substudy of the AEGIS-I Trial [0.03%]
新型载脂蛋白A-I制剂CSL112对急性心梗患者血清apoA-I和胆固醇流出能力的影响：一项子研究结果
C Michael Gibson,Syed Hassan A Kazmi,Serge Korjian et al.
C Michael Gibson et al.
Introduction: Cholesterol efflux capacity (CEC) is impaired following acute myocardial infarction (AMI). CSL112 is an intravenous preparation of human plasma-derived apoA-I formulated with phosphatidylcholine (PC). CSL112...