Atorvastatin, a New HMG-CoA Reductase Inhibitor as Monotherapy and Combined With Colestipol [0.03%]
新型HMG-CoA还原酶抑制药阿托伐他汀钙单用和与胆酸螯合剂colestipol合用的比较研究
TM Heinonen,H Schrott,JM McKenney et al.
TM Heinonen et al.
BACKGROUND: Atorvastatin, a new HMG-CoA reductase inhibitor in clinical development has demonstrated an acceptable safety profile and marked cholesterol and triglyceride reduction at doses ranging from 10-80 mg/day. Since bile acid sequeste...
Efficacy and Tolerability of Low-dose Simvastatin and Niacin, Alone and in Combination, in Patients With Combined Hyperlipidemia: A Prospective Trial [0.03%]
小剂量辛伐他汀及烟酸单用和合用治疗混合型高脂血症的疗效与安全性：一项前瞻性试验
EA Stein,MH Davidson,CA Dujovne et al.
EA Stein et al.
BACKGROUND: Combination lipid-lowering therapy may be desirable in patients with elevated low-density lipoprotein cholesterol, high triglycerides, and low high-density lipoprotein cholesterol. This study was conducted to determine the lipid...
A Comparison of the Tolerability and Efficacy of Lovastatin 20 mg and Fluvastatin 20 mg in the Treatment of Primary Hypercholesterolemia [0.03%]
洛伐他汀与氟伐他汀治疗高胆固醇血症的耐受性和有效性的比较研究
ML Berger,HM Wilson,CL Liss
ML Berger
BACKGROUND: To compare the cholesterol-lowering potency of fluvastatin and lovastatin, a randomized, prospective, open-label parallel study was conducted in patients eligible for drug therapy by National Cholesterol Education Program guidel...
The Effects of Amlodipine on Left Ventricular Mass and Diastolic Function in Concentric and Eccentric Left Ventricular Hypertrophy [0.03%]
氨氯地平对 concentric 和 eccentric 左心室肥厚患者左心室质量及舒张功能的影响
AS Fak,M Okucu,H Tezcan et al.
AS Fak et al.
BACKGROUND: The effects of the antihypertensive therapy with amlodipine (5-10 mg/day) on left ventricular mass and diastolic function were examined in 30 mild to moderate essential hypertensive patients who have left ventricular hypertrophy...
Data-driven Decisions: The Importance of Clinical Trials in Arrhythmia Management [0.03%]
数据驱动的决策：临床试验在心律失常管理中的重要性
JA Reiffel
JA Reiffel
As a result of clinical trials, the measurement of arrhythmias has evolved over the past three decades. In the late 1960s, customary teaching was that ventricular premature depolarizations were dangerous and antiarrhythmic therapy, in hopes...
Amiodarone Therapy After Previous Sotalol-induced Torsade de Pointes: Analysis of AT Dispersion to Predict Proarrhythmia [0.03%]
胺碘酮治疗之前索他洛尔诱发的尖端扭转型室速：分析AT离散度以预测促心律失常作用
van de Loo A,T Klingenheben,SH Hohnloser
van de Loo A
BACKGROUND: Polymorphic ventricular tachycardia of the torsade de pointes type represents, potentially, the most dangerous side effect of antiarrhythmic drugs that prolong ventricular repolarization. Much effort has been devoted to the iden...
Differences in the Effects of d- and dl-Sotalol on Isolated Human Ventricular Muscle: Electromechanical Activity After Beta-Adrenoceptor Stimulation [0.03%]
dl-与d-索他洛尔对人室肌β-肾上腺素能刺激后电生理及机械活动作用的差异性研究
DA Lathrop,A Varró,PP Nánási et al.
DA Lathrop et al.
BACKGROUND: The racemate of sotalol (dl-sotalol) and its dextrorotatory isomer (d-sotalol) are equally effective in increasing isolated cardiac action potential durations. dl-Sotalol, however, is reported to be more effective than d-sotalol...
Hydrochlorothiazide Increases Efferent Glomerular Arteriolar Resistance in Spontaneously Hypertensive Rats [0.03%]
氢氯噻嗪增加自发性高血压大鼠肾小球出球小动脉阻力
K Komatsu,A Numabe,Y Ono et al.
K Komatsu et al.
BACKGROUND: Micropuncture studies were performed to determine the intrarenal hemodynamic effects of two conventional antihypertensive agents, hydrochlorothiazide (HCTZ) and hydralazine (HYDR) alone and in combination. METHODS AND RESULTS: M...
Reduction of Myocardial Infarct Size in the Rabbit by a Carbohydrate Analog of Sialyl Lewis(x) [0.03%]
碳水化合物类SialylLewis(x)类似物减少兔心肌梗死面积
KS Kilgore,JL Park,L Chi et al.
KS Kilgore et al.
BACKGROUND: Available data suggest that the accumulation of neutrophils within the myocardium following an ischemic event plays an important role in the pathogenesis of myocardial ischemia/reperfusion injury. It is of interest, therefore, t...