Are Biopsy Specimens Effective for Evaluating HER2 Expression in Extrahepatic Bile Duct and Gallbladder Cancer? [0.03%]
活检标本用于评价胆管和胆囊癌HER2表达有效吗？
Osamu Inamori,Akio Yanagisawa,Yoko Hino et al.
Osamu Inamori et al.
Biliary tract cancer has a poor prognosis, with systemic chemotherapies showing limited benefit. New therapeutic targets are urgently needed to improve the prognosis of biliary tract cancer. Since HER2-targeted therapies have shown promisin...
Sinonasal Lymphoepithelial Carcinoma With Insulinoma-Associated Protein 1 (INSM1) Expression: A Potential Pitfall [0.03%]
表达胰岛素瘤相关蛋白1（INSM1）的鼻窦淋巴上皮癌：一种潜在的陷阱现象
Hebatullah Elsafy,Todd M Stevens
Hebatullah Elsafy
Sinonasal lymphoepithelial carcinoma (SNLEC) is a rare malignancy composed of poorly differentiated epithelial cells with syncytial morphology and a variably dense lymphoplasmacytic infiltrate. Nearly all reported tumors are associated with...
Laurence Aaron Galea,Lisa Aviva Friedman,Miruna Claudia Popescu et al.
Laurence Aaron Galea et al.
The finding of Pacinian corpuscles (PCs) in association with the prostate gland is an anatomical rarity. We present the largest series to date of 23 peri-prostatic PCs from 14 patients identified during routine reporting of radical prostate...
Gastrointestinal Kaposi Sarcoma in Inflammatory Bowel Disease: Clinicopathological, Endoscopic, and Follow-Up Study of 6 Patients With Review of the Literature [0.03%]
溃疡性结肠炎相关卡波西肉瘤的临床病理、内镜和随访研究及文献复习
Haider A Mejbel,Sarah Dry
Haider A Mejbel
Gastrointestinal Kaposi sarcoma (GI-KS) in inflammatory bowel disease (IBD) is exceedingly rare. Herein, we report 6 biopsy-proven HHV8(+)-GI-KS in IBD patients with a review of the literature. Our patients include 5 men and 1 woman, 26 to ...
Neuroendocrine Differentiation in Primary Head and Neck Mucosal Melanomas: Diagnostic Challenges and Clinical Implications in the United States [0.03%]
原发性头颈部黏膜黑色素瘤的神经内分泌分化：美国诊断挑战与临床意义
Aarohi Shah,Emilian Racila,Alessio Giubellino et al.
Aarohi Shah et al.
Primary head and neck mucosal melanoma is a rare and aggressive malignancy distinct from cutaneous melanoma, with no known association with UV exposure and a poorly understood pathogenesis. Diagnosis is often challenging due to its morpholo...
Deepsheikha Dhand,Neha Singh,Vishesh Dhawan et al.
Deepsheikha Dhand et al.
Only 43 patients with laryngeal melanosis have been reported to date. Concomitant malignancy and dysplasia of the upper aerodigestive tract, ranging from 26% to 50%, have been encountered with this condition. Given the above, we undertook t...
Endometriosis Involving the Bladder: A Contemporary Clinicopathologic Analysis of 88 Patients [0.03%]
88例膀胱受侵子宫内膜异位症的临床病理学分析
Thi T A Nguyen,Adeboye O Osunkoya
Thi T A Nguyen
Predominantly, case reports and small case series of endometriosis involving the bladder have been published. This study aimed to provide a contemporary clinicopathologic analysis of a large cohort of patients at a major academic center in ...
Pathological and Immunohistochemical Features of Malignant Peripheral Nerve Sheath Tumor With Heterologous Rhabdomy Oblastic Differentiation (Malignant Triton Tumor) in the Context of the Malignant Peripheral Nerve Sheath Tumor Spectrum [0.03%]
从恶性外周神经鞘瘤谱系看伴异源横纹肌母细胞分化的恶性外周神经鞘瘤（恶性トロン肿瘤）的病理及免疫组化特征
Luis Felipe Arias-Ruiz,Carlos Ortiz-Hidalgo
Luis Felipe Arias-Ruiz
Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas arising from Schwann cells or neurofibromas, comprising ∼10% of soft tissue sarcomas. Found in 8% to 13% of neurofibromatosis type 1 patients, they typically show spi...
Evaluation of a Limited Number of Histologic Levels in Prostate Needle Core Biopsies: Do Clinically Significant Cancer Parameters Go Undetected? [0.03%]
前列腺针芯活检中有限的组织学层次评估：临床意义重大的癌变参数是否会因此而被忽略？
Rosemary Mattaino,Valerie Cortright,Agnes Balla et al.
Rosemary Mattaino et al.
IntroductionIn the era of increasing prostate needle core biopsy (PNCB) burden with extended core and MRI-guided biopsies, recommendations are limited on how many histologic levels are needed to identify prostate cancer parameters. Many ins...
Florid Pseudosarcomatous Polypoid Fibroplasia: An Unusual Cutaneous Manifestation of Chronic Lymphedema [0.03%]
慢性淋巴水肿的不常见皮肤表现：假肉瘤样息肉状成纤维细胞增生症
Alexander N Perez,Jonathan L Curry,John E Madewell et al.
Alexander N Perez et al.
Bizarre, reactive fibroblastic proliferations associated with localized lymphedema may arise with chronic condom catheter use. We report a unique presentation of innumerable, cutaneous nodules occurring in chronic lymphedema of the right lo...