Primary Acantholytic Squamous Cell Carcinoma of the Breast With Basal-Like Immunophenotype and Low Proliferation: A Case Report and Literature Review [0.03%]
以基底样免疫表型和低增殖为主的乳腺原发棘皮瘤样鳞状细胞癌一例并文献复习
Elif Kardelen Çağdaş,Berkay Çağdaş,Emre Hafızoğlu
Elif Kardelen Çağdaş
BackgroundPrimary squamous cell carcinoma of the breast is an extremely rare subtype of metaplastic breast carcinoma, often showing aggressive clinical behavior and posing diagnostic challenges, particularly when acantholysis is present and...
Fat-Containing Minor Salivary Gland Proliferation of the Supraglottis: Challenging the "Ectopic" Paradigm [0.03%]
声门上含有脂肪的_minor_唾液腺增生：挑战“异位”理念
Mahi Balcı,Ziya Şencan,Onur Aydoğan
Mahi Balcı
Laryngeal lesions reported as "ectopic" salivary gland tissue are exceedingly rare, with fewer than 10 examples documented. The histogenesis of these lesions remains uncertain, and the terminology applied has not been critically reevaluated...
Primary Renal Perivascular Epithelioid Cell Tumor with CLTC::TFE3 Gene Fusion: A Rare Gene Fusion and Masquerading as Renal Cell Carcinoma [0.03%]
以CLTC::TFE3基因重排为特征的原始肾周上皮样细胞肿瘤一例，并模拟肾细胞癌
Geethanjali Gude,Hilda Mirbaha,Liwei Jia
Geethanjali Gude
We report a primary perivascular epithelioid cell tumor (PEComa) of the kidney harboring a novel CLTC::TFE3 gene fusion in a 51-year-old woman. The tumor was composed of high-grade epithelioid cells with clear to eosinophilic cytoplasm arra...
Metastatic Melanoma with Rhabdomyosarcomatous Transdifferentiation: Two Tumors with Next-Generation Sequencing Correlation [0.03%]
伴有向横纹肌肉瘤样转分化的转移性黑色素瘤：有下一代测序相关性的两例肿瘤
Myles R McCrary,Kathryn Brimanson,Oluwatobi Ozoya et al.
Myles R McCrary et al.
Metastatic melanoma can present significant diagnostic challenges when it undergoes both loss of differentiation and transdifferentiation, leading to the loss of melanocytic markers and acquisition of features mimicking other malignancies. ...
Clinicopathologic Analysis of Undifferentiated Carcinoma of the Pancreas With Osteoclast-Like Giant Cells [0.03%]
未分化胰腺癌伴巨细胞(类似破骨细胞)的临床病理分析
Kaijian Zhang
Kaijian Zhang
ObjectiveTo investigate the clinicopathological features, differential diagnosis, and prognosis of undifferentiated carcinoma of the pancreas with osteoclastic giant cells (UCOGCP).MethodsThe clinical histomorphological features and immunoh...
Non-Invasive Papillary Urothelial Carcinoma With "Plasmacytoid" Morphology: A Retrospective Review of 500 Consecutive Specimens [0.03%]
非侵袭性乳头状尿路上皮癌伴“浆细胞样”形态：500例连续标本的回顾性分析
Mariya Kuk,Emily Chan,Ankur R Sangoi
Mariya Kuk
We have anecdotally encountered non-invasive (pTa) papillary urothelial carcinomas (PUCs) with eccentric nuclear localization and eosinophilic globular cytoplasm, imparting a "plasmacytoid" appearance, with inconsistent grading in clinical ...
Adenomyomatous Hyperplasia of the Vaterian System: The Hidden Culprit Behind Whipple Procedures [0.03%]
沃德尔系统腺肌增生： Whippp手术背后的隐匿性病灶
Bharathi Prabakaran,Kumble S Madhusudhan,Rajesh Panwar et al.
Bharathi Prabakaran et al.
IntroductionAdenomyomatous hyperplasia (AH) of the Vaterian system is a rare benign lesion, often clinically mistaken for carcinoma and leading to unnecessary Whipple surgery.MethodsIn this multicentre cohort, Whipple pancreaticoduodenectom...
Early-Stage High-Grade Fetal Lung Adenocarcinoma With KRAS Mutation: A Rare Presentation and Literature Review [0.03%]
早中期高分化胎儿型肺腺癌合并KRAS突变一例及文献复习
Baoxiang Pei,Zhiliang Hu,Fen Pan
Baoxiang Pei
IntroductionFetal lung adenocarcinoma is a rare malignant lung tumor, constituting about 0.1% to 0.5% of primary lung tumors. It is categorized into two types based on histopathological and clinical differences: low-grade and high-grade typ...
Hao Yang,Mu-Zi Yang,Lei Yuan et al.
Hao Yang et al.
Langerhans cell histiocytosis (LCH) is a rare clonal proliferative disorder originating from dendritic cells and primarily occurring in children. Although pulmonary LCH is relatively common among adult smokers, isolated mediastinal involvem...
Sarcomatoid Carcinoma of the Prostate With Both Chondrosarcomatous and Osteosarcomatous Differentiation Following Androgen Deprivation Therapy: A Case Report and Diagnostic Considerations [0.03%]
雄激素剥夺治疗后伴有软骨肉瘤和骨肉瘤分化的前列腺肉瘤样癌：一例报告及诊断思考
Pelin Akbas,Sibel Bektas,Mucahit Gelmis et al.
Pelin Akbas et al.
BackgroundSarcomatoid carcinoma of the prostate is a rare and aggressive biphasic malignancy, typically arising in the setting of prior prostatic adenocarcinoma. Prominent heterologous differentiation may obscure its epithelial origin and l...