Correlation between sperm DNA fragmentation and methylation in male partners of couples with idiopathic recurrent pregnancy loss [0.03%]
男性精子DNA碎片和甲基化之间关系与不明原因复发性流产配偶的关系研究
Delna Irani,Deepti Tandon,Vandana Bansal et al.
Delna Irani et al.
With ∼50% recurrent pregnancy loss cases being termed idiopathic (iRPL), understanding of contribution of male factors to iRPL is still lacking. Higher prevalence of sperm DNA fragmentation index (DFI) and lower sperm 5-methylcytosine (5-m...
Novel bioinformatic analyses of somatic cell contamination in sperm samples [0.03%]
新型生物信息学分析精液样品中的体细胞污染问题
Carter Norton,Chad Pollard,Kelaney Stalker et al.
Carter Norton et al.
The assessment of epigenetic profiles in sperm is sensitive to somatic cell contamination, which can influence methylation signals at gene promoters. This contamination is particularly problematic in the assessment of DNA methylation in sam...
Association of lifestyle and occupational exposure factors with human semen quality: a cross-sectional study of 1060 participants [0.03%]
生活习惯及职业暴露因素与男性精子质量的关系：一项针对1060名参与者的横断面研究
Wen Yang,Zongliu Duan,Guanjian Li et al.
Wen Yang et al.
The incidence of male infertility (MI) is rising annually. However, the lifestyle and occupational exposure factors contributing to MI remain incompletely understood. This study explored the effects of self-reported lifestyle and occupation...
Study of the genomics and transcriptomics profiles of male-infertility genes in human prostate cancer: an in silico analysis [0.03%]
人前列腺癌男性不育基因组学和转录组学特征的计算分析研究
Farima Said Ali-Samani,Arman Shahrisa,Maryam Tahmasebi-Birgani et al.
Farima Said Ali-Samani et al.
The World Health Organization has considered the infertility as an international public health problem. Infertility affect nearly 1 in 7 couples and male component contributes to 50% of infertility cases. There is a clear link between male ...
Moderate concentration of Lactobacillus metabolites does not adversely affect mouse sperm [0.03%]
适量的乳杆菌代谢产物不会对小鼠精子产生不利影响
Katarzyna Kotarska
Katarzyna Kotarska
Many couples in contemporary societies suffer from infertility of unexplained origins (idiopathic). A promising treatment strategy within this context involves the administration to women of preparations containing lactic acid bacteria (Lac...
Active immunization with recombinant GnRH6-CRM197 inhibits reproductive function of male rats [0.03%]
用重组GnRH6-CRM197免疫可抑制雄性大鼠的生殖功能
XinBao Gong,Xu Yan,MengXian Li et al.
XinBao Gong et al.
Gonadotropin-releasing hormone (GnRH) vaccines have been successfully used for the inhibition of gonadal development and function, but current GnRH-based vaccines often present variability in the response. Cross-reactive material 197 (CRM19...
FOXA1 co-activates circODC1 and ODC1 in HPV-positive cervical cancer cell growth [0.03%]
FOXA1通过协同活化circODC1和ODC1促进人乳头瘤病毒阳性宫颈癌细胞增殖
Rong Jin,Hongfang Li,Shoushan Nan et al.
Rong Jin et al.
As demonstrated in previous research, hsa_circ_0052602 (circODC1) is dynamically expressed in HPV-positive cervical cancer (CC). CircODC1 expression was quantified using qRT-PCR, and its role in CC cell growth was assessed via loss-of-funct...
Correlation between standard sperm parameters and sperm DNA fragmentation from 11,339 samples [0.03%]
11339份标本精子参数与精子DNA碎片化的相关性分析
Tingting Yang,Lin Yu,Jinyan Xu et al.
Tingting Yang et al.
Conventional semen parameters have long been considered fundamental in male fertility analyses. However, doubts have been raised regarding the clinical utility of the assessment of spermatozoa (sperm) DNA damage. In this retrospective study...
Prediction of deleterious non-synonymous SNPs of human MDC1 gene: an in silico approach [0.03%]
人类MDC1基因有害非同义SNP的预测：一种计算机模拟方法
Vaishnavee Thote,Susha Dinesh,Sameer Sharma
Vaishnavee Thote
MDC1 (Mediator of DNA damage Checkpoint protein 1) functions to facilitate the localization of numerous DNA damage response (DDR) components to DNA double-strand break sites. MDC1 is an integral component in preserving genomic stability and...
Rebeka Podgrajsek,Alenka Hodzic,Martin Stimpfel et al.
Rebeka Podgrajsek et al.
Male infertility is a reproductive disorder, accounting for 40-50% of infertility. Currently, in about 70% of infertile men, the cause remains unknown. With the introduction of novel omics and advancement in high-throughput technology, pote...