cPKCγ facilitates the apoptosis of mouse GC-1 spg cells by regulating the mitophagy via inhibiting the UCHL1/HIF‑1α axis [0.03%]
cPKCγ通过抑制UCHL1/HIF-1α轴调节线粒体自噬从而促进GC-1spg细胞凋亡
Huajun Yang,You Tian,Shaoguang Feng et al.
Huajun Yang et al.
Cryptorchidism, among the most frequent congenital urogenital anomalies in male infants, has a global prevalence ranging from 1% to 9%. Characterized by failure of testicular descent into the scrotum, such a condition exposes the testes to ...
Defining optimal frame rate for kinematic semen analysis of different dog breeds assessed by computer-assisted sperm analysis [0.03%]
不同犬种运动精子分析的最优帧率定义及计算机辅助精子分析评估
Francisco Sevilla,Marcos Campos,Ignacio Araya-Zúñiga et al.
Francisco Sevilla et al.
The development of computer-assisted sperm analysis (CASA) systems has expanded the number of analyzable seminal parameters. The aim of this study was to define the optimal frame rate analysis using CASA-Mot system, and to evaluate the effe...
Embryology and clinical outcomes after sperm preparation using microfluidic sperm sorting versus density gradient centrifugation [0.03%]
精子微流体分选与密度梯度离心制备的胚胎学及临床结局分析
Hanna Balakier,Iryna Kuznyetsova,Banafshe Gholamhoseini et al.
Hanna Balakier et al.
This retrospective study aims to compare laboratory and clinical outcomes of a microfluidic sperm sorting device (ZyMōt) versus a standard density gradient centrifugation (DGC) technique in ICSI cycles using autologous or donor oocytes. A ...
Diagnostic and surveillance strategies for Marburg virus persistence in the male reproductive tract: insights from Ebola and Zika viruses [0.03%]
马堡病毒在男性生殖道中持续存在的诊断和监测策略：埃博拉病毒和寨卡病毒的启示
Martin Ndayambaje,Karim Zaher,Hicham Wahnou et al.
Martin Ndayambaje et al.
The recent outbreak of the Marburg virus (MARV) in Rwanda was effectively controlled, but concerns remain regarding the virus's persistence and its long-term effects. MARV can remain in the testes of nonhuman primates, where it harms Sertol...
Mohamed Aboul Ezz,Ahmed Zaky Balboula
Mohamed Aboul Ezz
Folliculogenesis is a complex, multi-stage process crucial for the establishment and maintenance of female fertility through the production of a developmentally competent oocyte. Folliculogenesis, including follicular formation, activation,...
Future directions in infertility research: the role of generative AI and large language models [0.03%]
未来生育研究的方向：生成式AI和大型语言模型的作用
Hasan M Jamil
Hasan M Jamil
Male infertility remains an understudied yet significant contributor to global reproductive health challenges, with up to 50% of infertility cases involving a male factor and a large proportion still classified as idiopathic. Recent advance...
Metabolomic analysis of follicular fluid in women with unexplained infertility [0.03%]
不明原因不孕妇女卵泡液代谢组学分析
Durva Panchal,Aishani Bose,Grishma Desai et al.
Durva Panchal et al.
Unexplained infertility (UI) affects ∼10% of infertile couples, yet standard diagnostic protocols fail to identify a cause. Follicular fluid (FF), which supports oocyte development, contains metabolites that may reflect underlying molecula...
HDAC6 interacting-microtubule associated proteins (HMAPs) identified in human sperm [0.03%]
人精子中与HDAC6相互作用的微管相关蛋白(HMAPs)的鉴定
Veena Chawan,Aniket Patankar,Smita Yevate et al.
Veena Chawan et al.
Sperm flagellar axoneme comprises microtubules (MT) and associated machinery and is an integral determinant of sperm motility. Reports from our lab show reduced levels of acetyl α-tubulin, and HDAC6, along with compromised axoneme polymeri...
Aberrant epithelial differentiation may contribute to endometrial polyp formation: insights from single-cell analysis [0.03%]
上皮分化异常可能导致子宫内膜息肉的发生：单细胞分析的新见解
Amruta D S Pathare,Ankita Lawarde,Katrin Täär et al.
Amruta D S Pathare et al.
Endometrial polyps (EPs) are benign overgrowths of the endometrium causing abnormal uterine bleeding and infertility. Despite their clinical significance, the molecular mechanisms underlying their development and recurrence remain poorly un...
Novel DNAH1 variants in Chinese males with MMAF-associated asthenoteratozoospermia [0.03%]
DNAH1新变异与MMAF相关性腺肌病伴弱精症
Kun Ye,LeiYu Deng,Fei Huang et al.
Kun Ye et al.
Asthenoteratozoospermia is a major contributor to male infertility, with multiple morphological abnormalities of the flagellum (MMAF) representing a genetically heterogeneous disorder characterized by structural defects in sperm flagella. T...