Reproductive microbiota in humans: characterization and role in infertility [0.03%]
人类生殖微生物组的特征及其在不孕症中的作用
Rebecca Poole,Dallas Soffa,Kyle Hickman et al.
Rebecca Poole et al.
Advancements in next generation sequencing technologies, including 16S rRNA amplicon sequencing, have vastly expanded our understanding of reproductive microbiota and its role in fertility. For example, in humans, the bacterial genus of Lac...
Investigation of testis proteome alterations associated with male infertility in Dcaf17-deficient mice [0.03%]
Dcaf17缺陷小鼠睾丸蛋白质组变化与男性不育关联性的研究
Bhavesh Mistry,Ayodele Alaiya,Raed Abu-Dawud et al.
Bhavesh Mistry et al.
Disruption of Dcaf17 in mice resulted in male infertility with severe spermatogenesis defects. To investigate the molecular basis of infertility phenotype, we examined testicular proteomes of wild-type (WT) and Dcaf17-/- mice using a mass s...
Fetal macrosomia and placental expression of fibroblast growth factor 21 and peroxisome proliferator-activated receptor alpha [0.03%]
胎儿巨大儿和纤维细胞生长因子21及过氧化物酶体增殖激活受体alpha在胎盘的表达
Rachel K Harrison,Katherine Allen,Aaron Naatz et al.
Rachel K Harrison et al.
Macrosomia (birth weight >4000 g) is a product of endocrine dysfunction in utero leading to fetal overgrowth and can lead to maternal and infant morbidity. Fibroblast growth factor 21 (FGF21) and its transcription factor, peroxisome prolife...
Correlation of placenta previa and liver enzyme abnormalities with recurrent pregnancy loss in women [0.03%]
胎盘前置和肝酶异常与女性反复流产的相关性研究
Eyman Al-Ali,Iman Mohammed Said Jallod
Eyman Al-Ali
Recurrent pregnancy loss (RPL) affects 1% to 5% of women of reproductive age, Even after thoroughly evaluating recurrent pregnancy loss etiology and risk factors about 75% of cases remaining unexplained. While the roles of hormonal imbalanc...
Dissecting the shared molecular mechanisms underlying polycystic ovary syndrome and schizophrenia etiology: a translational integrative approach [0.03%]
拆解多囊卵巢综合征和精神分裂症发病机制的共同分子机制：一种转化整合方法
Dilek Pirim,Fatih Atilla Bağcı
Dilek Pirim
Recent evidence suggests that individuals with polycystic ovary syndrome (PCOS) have an increased risk of developing mental health disorders and comorbidities linked to nervous system dysfunction. Interestingly, patients with schizophrenia ...
Novel homozygous missense variants in SUN5 and DNAH10 associated with male infertility and oligoasthenoteratozoospermia [0.03%]
与男性不育和弱精症相关的SUN5和DNAH10全新纯合错义变异体
Qi Fang,Lanxi Ran,Xinying Bi et al.
Qi Fang et al.
Genetic variants are known causes of male infertility and oligoasthenoteratozoospermia (OAT), as shown by knockout mouse models and patients with infertility. However, most OAT cases lack a definitive genetic diagnosis. Peripheral blood and...
Dimitrios Ioannou,Helen G Tempest
Dimitrios Ioannou
This review provides a comprehensive overview of the genetic factors underlying male and female infertility. Infertility affects an estimated one in six couples worldwide, with both male and female factors contributing equally to its preval...
Overview of infertility [0.03%]
不孕不育概述
Awoniyi O Awonuga,Olivia G Camp,Mia M Biernat et al.
Awoniyi O Awonuga et al.
Having a child is an innate trait in animals, including humans, and is required for the continued existence of all animal species. Therefore, for most women, the inability to conceive or to do so in a timely fashion - termed infertility - t...
Whole exome sequencing uncovers rare variants associated with PCOS susceptibility in Indian women [0.03%]
全外显子测序揭示了与印度女性PCOS易感性有关的罕见变异
Medini Samant,Mahalakshmi Bhat,Roshan Dadachanji et al.
Medini Samant et al.
Polycystic ovary syndrome (PCOS) is a complex polygenic endocrinopathy affecting 5-20% of reproductive-age women. Familial studies, candidate gene studies, and GWAS have identified multiple PCOS-associated genetic loci. This study aims to i...
Influence of tannin-rich extract from commercial Acacia mearnsii and gallocatechin on ovine cryopreserved semen viability [0.03%]
富含单宁的商业黑木黄檀提取物和没食子儿茶精对冷冻绵羊精液活力的影响
Mohammed S Liman,Abubeker Hassen,Mario P Smuts et al.
Mohammed S Liman et al.
The objective of this study was to evaluate the effect of a tannin-rich extract from commercial Acacia mearnsii (MTE_0), and gallocatechin, a flavonoid compound derived from Acacia mearnsii, on the long-term viability and motility of cryopr...