Fertilization and oocyte activation: overview, updates, and novel hypotheses from a molecular perspective [0.03%]
从分子角度概述、更新和提出新的假说：受精与卵子活化
Valentina Di Nisio,Peter Sutovsky,Sevastiani Antonouli et al.
Valentina Di Nisio et al.
The multifaceted process of fertilization encompasses a precisely orchestrated cascade of molecular and morphological modifications of the participating male and female gametes. Fertilization culminates in the union of the maternal and pate...
George Anifandis,Helen G Tempest,Dimitrios Ioannou et al.
George Anifandis et al.
The use of assisted reproductive therapies, advances in embryo research, and developments in scientific fields such as gene editing and in vitro gametogenesis have attracted the attention of bioethicists for years. On one side, the 14-day r...
Tracing refractile body biogenesis in human oocytes: the role of lysosomes and mitochondria [0.03%]
人卵母细胞折射颗粒的发生学：溶酶体和线粒体的作用
Yuto Aoki,Xingqiang Wei,Mikiya Nakatsuka et al.
Yuto Aoki et al.
Refractile bodies (RBs) in human primordial oocytes may represent a lysosomal mechanism of cellular waste management independent of hormonal stimulation or age. This observational study investigated the ultrastructural features and molecula...
Observational Study
Systems biology in reproductive medicine. 2026 Dec;72(1):73-86. DOI:10.1080/19396368.2025.2610348 2026
A novel homozygous variant of AURKC causes macrozoospermia in a Chinese family [0.03%]
中国一家系男性不育的病因是AURKC同合子变异导致的巨精子症
Jian Zhang,Yijia Zhao,Liwen Deng et al.
Jian Zhang et al.
Macrozoospermia is a rare cause of male infertility characterized by a high proportion of sperm with large, irregular heads. In this study, we identified a novel homozygous Aurora kinase C (AURKC) missense variant (c.253G > A (p.Glu85Lys)) ...
Mitko Madjunkov,Svetlana Madjunkova,Clifford Librach
Mitko Madjunkov
Female infertility is a multifactorial condition with complex biological and clinical underpinnings. Biologically, female-related infertility may stem from disruptions in the hypothalamic-pituitary-ovarian (HPO) axis, impaired folliculogene...
Possible mechanisms and clinical innovations of sequential embryo transfer in assisted reproduction [0.03%]
辅助生育中序贯胚胎移植的可能机制及临床创新
Lina Ma,He Zhu,Pengyun Zhu et al.
Lina Ma et al.
This review comprehensively discusses the innovative value and scientific mechanism of sequential embryo transfer (SET) technology in assisted reproduction. SET, by transferring embryos in stages, offers a novel approach to address clinical...
Tasrin Sultana,Peter Sutovsky
Tasrin Sultana
The male gamete, the spermatozoon, is the carrier of paternal inheritance. Besides paternal genome, the spermatozoon contributes essential factors for successful fertilization, embryonic development, and continuation of species. A dynamic a...
SBiRM 2026 [0.03%]
SBiRM 2026会议
Stephen A Krawetz
Stephen A Krawetz
A novel sperm FcR binding assay that assesses sperm fertilizing potential [0.03%]
一种评估精子受精潜力的新型精子FcR结合试验
Barb Cohen,John Walsh,Zimu Chen et al.
Barb Cohen et al.
Freshly ejaculated mammalian sperm have poor fertilizing ability, with fertility only gained after sperm undergo capacitation and the acrosome reaction. To visualize exposed Fc receptors (FcRs), which occur during the acrosome reaction and ...
Novel insights on cryostress, cryoinjury and cryotolerance in sperm - a review [0.03%]
精子冷冻应激、冷伤及冷耐受的新见解——综述文章
Balaganur Krishnappa,Bala Krishnan Binsila,Arunachalam Arangasamy et al.
Balaganur Krishnappa et al.
Sperm cryopreservation is a critical component of assisted reproductive technologies employed for both livestock breeding and human fertility management. Sperm are the highly specialized motile cells prone to cryodamage during freezing. Mor...