RANKL-inducible Arl8b effector RUFY4 drives HOPS-mediated lysosomal maturation and trafficking in osteoclasts [0.03%]
破骨细胞中RANKL诱导的Arl8b效应物RUFY4通过HOPS复合体介导溶酶体成熟和转运
Kshitiz Walia,Gaurav Kumar,Subhash B Arya et al.
Kshitiz Walia et al.
Osteoclast-mediated bone resorption depends on the secretion of lysosomal hydrolases via the fusion of secretory lysosomes with the ruffled border, yet the molecular mechanisms governing lysosomal trafficking and fusion remain incompletely ...
Can Yin,Wanxin Tang,Yihao Fu et al.
Can Yin et al.
γ-Tubulin assembles into the γ-tubulin ring complex (γTuRC) that acts as the primary nucleator of cellular microtubules. γ-Tubulin binds Mg²⁺-associated GTP or GDP in an exchangeable manner; however, the nature of its GTP/GDP-binding ...
Steady-state epithelial apical flatness is characterized by MLCK morphodynamics and asynchronous Ca2+ oscillations, but not by underlying ECM geometry [0.03%]
steady-state上皮顶点平坦性由MLCK形态动力学和非同步Ca2+振荡而非基底ECM几何特征决定
Hao Wu,Emerson Herrmann,Jeanette Hyer et al.
Hao Wu et al.
The canonical simple epithelium is a flat sheet-like tissue of horizontally packed cells. While the basal surface is delineated by the basement membrane of extracellular matrix (ECM), little is known about how a flat apical surface is maint...
Interplay between membrane protrusive activities and their adhesion strength regulates cell migration [0.03%]
细胞膜突出活动与黏附强度的相互作用调控细胞迁移
Indranil Ghosh,Ditipriya Mallick,Ankita Sen et al.
Indranil Ghosh et al.
Migratory cells can adopt membrane protrusions like blebbing or lamellipodia for efficient migration. The underlying mechanisms of how switching contributes to cell migration are not clearly understood. Here, we found that nonmuscle myosin ...
A role for Keratin 17 in Rac1-mediated DNA damage response in keratinocytes [0.03%]
角蛋白17在Rac1介导的角质形成细胞DNA损伤反应中的作用
Christopher Pineda,Erez Cohen,Beau Su et al.
Christopher Pineda et al.
Keratin 17 (K17) is a stress-responsive intermediate filament protein that is upregulated in chronic skin diseases and in several carcinomas. We previously showed that K17 is induced in epidermal keratinocytes following exposure to DNA-dama...
Local RhoA activation induces anillin-independent septin recruitment in interphase cells [0.03%]
活化RhoA可使分裂间期细胞发生不依赖于anillin的Septin募集作用
Shreya Chandrasekar,Margaret E Utgaard,Bradley Somerfield et al.
Shreya Chandrasekar et al.
The regulation of the actin cytoskeleton is key to controlling cell shape and structure. While the Rho GTPase RhoA is well known to regulate the actomyosin cytoskeleton, its function in controlling the septin cytoskeleton remains unclear. A...
MCTP1 and MCTP2 promote ER-PM contact sites and regulate PI4P homeostasis and cell migration [0.03%]
MCTP1和MCTP2促进内质网-质膜接触点并调控磷脂4磷酸盐稳态和细胞迁移
Suganthan Amirthagunanathan,Maxime Boutry,Vasudeva Tati et al.
Suganthan Amirthagunanathan et al.
Endoplasmic reticulum-plasma membrane (ER-PM) contact sites play important roles in maintaining lipid homeostasis at the plasma membrane (PM), cellular calcium homeostasis, and cell signaling. Here, we show that MCTP1 and MCTP2 are at ER su...
Breaking the annotation barrier: An initial subcellular localization atlas of Giardia's hypothetical and conserved hypothetical proteins provides a resource for functional discovery [0.03%]
突破注释障碍：叶绿体假定蛋白和保守假定蛋白亚细胞定位图谱的初步研究为功能发现提供资源
Kari D Hagen,Alexander J Zerkle,Satvik Arani et al.
Kari D Hagen et al.
Giardia intestinalis is a globally prevalent cause of waterborne diarrheal disease, yet about 40% of its proteome remains functionally uncharacterized due to the lack of conserved homologous proteins and limited experimental validation of p...
A minimal model for the role of Rim4 in regulating meiotic exit in budding yeast [0.03%]
芽殖酵母Rim4调控减数分裂退出功能的简约模型研究
V Abigail Marquez Davila,Pallavi Gadgil,Anna Zike et al.
V Abigail Marquez Davila et al.
Meiosis ensures formation of haploid gametes through two rounds of chromosome segregation after one round of DNA replication. How this cell cycle process is restricted to two and only two divisions is poorly understood. In budding yeast, RN...
The microtubule GTP-tubulin cap size is modulated during cell division [0.03%]
细胞分裂过程中微管GTP-微管帽大小的变化
Anna C Cassidy,Dylan T Burnette,Marija Zanic
Anna C Cassidy
Microtubule dynamics change during cell division to enable rapid microtubule network remodeling. The switching from microtubule growth to shrinkage is attributed to the loss of a stabilizing GTP-cap structure at the growing microtubule end....