Janelle S Bellot,Siyuan Hao,Yihuan Li et al.
Janelle S Bellot et al.
Yes-associated protein (YAP) condensates are critical for cell survival under hyperosmotic stress, yet how these condensates execute their specific functions remains incompletely understood. Here, we employed proximity-based proteomics to i...
ARHGAP18 complexes with both YAP and Merlin and is required for basal actin bundles [0.03%]
ARHGAP18与YAP和Merlin形成复合体并要求形成基底肌动蛋白簇群
Emma C Murray,Gillian M Hodge,Khanh Pham et al.
Emma C Murray et al.
The organization of the cell's cytoskeletal filaments is coordinated through a complex network of signaling cascades activated by both internal and external cues. Two major actin regulatory pathways are signal transduction through Rho famil...
An integrated proximity labeling and vesicle reconstitution assay identifies novel regulators of Sonic hedgehog secretion [0.03%]
整合的邻近标记和囊泡重构测定鉴定新型Sonic Hedgehog分泌调节因子
Ziyang Song,Zixin Chen,Ye Tian et al.
Ziyang Song et al.
Protein trafficking is a fundamental process for cellular organization and signaling. However, identifying the specific machinery that packages cargo into transport vesicles has been a significant challenge. Conventional proximity biotinyla...
Molecular and Cellular Determinants of Human Iron Overload Cardiomyopathy [0.03%]
人类铁负荷性心肌病的分子和细胞决定因素
Sayli S Modak,Lina Greenberg,W Tom Stump et al.
Sayli S Modak et al.
Iron overload cardiomyopathy (IOC) is caused by elevated systemic iron, and it is characterized by systolic and diastolic dysfunction as well as arrhythmias. Isolating the cardiac-specific cellular and molecular mechanisms driving IOC has b...
The basement membrane determines the choice of wound healing mechanism across wound scales in the basal eukaryote Clytia hemiphaerica [0.03%]
无细胞外基质时采自基部后生动物Clytia hemisphaerica的伤口愈合机制
Jocelyn E Malamy,Maxwell Sassaman,Manjula P Mony
Jocelyn E Malamy
Epithelial wound healing is an essential process in multicellular organisms, primarily driven by lamellipodia-based crawling, purse-string contraction, and collective cell migration. One or more of these mechanisms participate in healing a ...
Coordinated chromosome motion emerges from mechanical coupling mediated by the physical spindle environment [0.03%]
由物理纺锤体环境介导的机械耦合产生的协调染色体运动
Jiali Zhu,Ehssan Nazockdast,Paul S Maddox et al.
Jiali Zhu et al.
During metaphase, chromosomes undergo oscillatory motion and exhibit distance-dependent coordinated movement with neighboring chromosomes within the spindle. However, the physical mechanism that gives rise to coordinated chromosome motion r...
Stage- and stress-specific phosphorylation of ribosomal protein Rps5 (uS7) by Smk1 and Kns1 kinases in Saccharomyces cerevisiae [0.03%]
酿酒酵母中Smk1和Kns1激酶对核糖体蛋白Rps5（uS7）的阶段特异性和压力特异性磷酸化
Gwendolyn Resch,Thomas Swayne,Erica Johnson et al.
Gwendolyn Resch et al.
In the yeast Saccharomyces cerevisiae, nutrient deprivation triggers cell-type-specific responses: haploid cells exit the mitotic cycle and enter stationary phase, while diploid cells undergo meiosis and form spores. The meiosis-specific mi...
Neuronal extracellular vesicles regulate axon development in primary cortical neurons via local miR-99a targeting of HS3ST2 [0.03%]
神经元细胞外囊泡通过局部miR-99a靶向HS3ST2调节皮层神经元轴突发育
Raquel Mesquita-Ribeiro,Alex Rathbone,Paula Jackson et al.
Raquel Mesquita-Ribeiro et al.
Fully functional neural competence and integrity requires a complex array of communication means among neurons, with extracellular vesicles (EVs) emerging as a relevant mechanism for cell-cell interaction in the CNS. Despite the growing num...
Pex3p phosphorylation modulates recruitment of myosin V adapters Inp2p and Pex19p to regulate peroxisome partitioning in yeast [0.03%]
Pex3p磷酸化通过调节肌球蛋白V适配器Inp2p和Pex19p的募集来调控酵母过氧化物酶体分配
Barbara Knoblach,Richard A Rachubinski
Barbara Knoblach
Yeast cells rely on the actomyosin machinery to mediate organelle motility. The type V myosin motor Myo2p transports organelles along actin cables from the mother cell to nascent bud. To facilitate this process, organelles have evolved spec...
Density-Aware Spatial Randomization (DenSR) Generates Realistic Null Models for Object-Based Colocalization Analysis [0.03%]
密度感知空间随机化(DenSR)生成了基于对象的共定位分析的实际虚拟模型
Sudharsan Kannan,Taylor L Voelker,Benjamin S Snyder et al.
Sudharsan Kannan et al.
Quantitative colocalization analysis in fluorescence microscopy is widely used to study molecular interactions among proteins, RNAs, and other cellular components. Object-based approaches identify discrete molecular features and quantify di...