APCCdh1-mediated degradation of Cdh1 is necessary for faithful meiosis in S. cerevisiae [0.03%]
APCCdh1介导的Cdc20降解对酵母减数分裂的忠实性是必需的
Denis Ostapenko,Mark J Solomon
Denis Ostapenko
The Anaphase-Promoting Complex/Cyclosome (APC/C) is a ubiquitin ligase that promotes the ubiquitination and subsequent degradation of numerous cell cycle regulators during mitosis and in G1. Proteins are recruited to the APC/C by activator ...
The scaffold protein PRR14L is linked to mitotic fidelity and sensitivity to MPS1 inhibition [0.03%]
支架蛋白PRR14L与有丝分裂保真性和对MPS1抑制的敏感性相关
Albert Z Liu,Akshay Narkar,Keming Li et al.
Albert Z Liu et al.
Aneuploidy is a hallmark of cancer and is a potential vulnerability that can be selectively targeted. To systematically identify genes that affect the incidence and fitness of aneuploid cells, we conducted a genome-wide CRISPR/Cas9 screen u...
Analysis in vivo using a new method, ARGO (Analysis of Red Green Offset), reveals complexity and cell-type specificity in presynaptic turnover of synaptic vesicle protein Synaptogyrin/SNG-1 [0.03%]
一种新的体内分析方法(ARGO)揭示了突触囊泡蛋白在前突触中的复杂性和细胞类型特异性转换现象
Nikita Shiliaev,Manuel A Alvarez,Ruiling Zhong et al.
Nikita Shiliaev et al.
In long-lived cells such as neurons, proteostasis involves the regulated degradation and replacement of proteins to ensure their quality and appropriate abundance. Synaptic vesicle (SV) protein turnover in neurons is important for controlli...
Recruitment of the outer-membrane lipoprotein DolP to the division site via anionic phospholipid-mediated diffusion-state switching [0.03%]
外膜脂蛋白DolP通过阴离子磷脂介导的扩散状态转换募集到分裂部位
Jinchan Xue,Di Yan,Jiajia Wang et al.
Jinchan Xue et al.
In diderm bacteria, the outer membrane (OM) must invaginate in concert with septal peptidoglycan (PG) remodeling during cytokinesis. One OM lipoprotein, DolP, has been shown to localize at the cell division site and facilitate the daughter ...
Long isoforms of Espin and Espin-Like proteins are essential for development and maintenance of mechanotransducing stereocilia [0.03%]
Espin和Espin-Like长异构体是机械感受立体纤毛发育和维持的必需条件
Katelin M Hawbaker,Priyanka Joshi,Xiayi Liao et al.
Katelin M Hawbaker et al.
Stereocilia are giant, specialized microvilli on auditory sensory cells in the inner ear. Their precise size and tiered organization is essential for function and strictly controlled by actin-regulating proteins during postnatal development...
RanBP2-dependent SUMOylation of G3BP2 inhibits formation, and promotes disassembly, of stress granules [0.03%]
RanBP2依赖的G3BP2SUMO化抑制应激颗粒的形成并促进其解聚
Yifan E Wang,Javid Guliyev,Sean S J Ihn et al.
Yifan E Wang et al.
Stress granules and processing bodies (P-bodies) are dynamic cytoplasmic ribonucleoprotein (RNP) condensates that coordinate translation inhibition, mRNA storage, and decay during cellular stress. Emerging evidence suggests that SUMOylation...
Bacterial ecology in confined and spatially structured in vitro habitats [0.03%]
限定且空间分布明确的体外栖息地中细菌生态学研究
Faisal Halabeya,Ing Xhu Lim,Joshua N Milstein
Faisal Halabeya
Bacteria commonly coexist within communities where they compete for limited space and resources. These communities play an essential role in supporting a diversity of critical ecosystems from regulating metabolism within the gut to cycling ...
Ultrastructural studies reveal a new role for JIP3/MAPK8IP3 in endo-lysosomal maturation within the neuronal cell body [0.03%]
ultrastructural研究揭示JIP3 / MAPK8IP3在神经元细胞体中内溶酶体成熟中的新作用
Mia Krout,Swetha Gowrishankar
Mia Krout
In recent years, substantial heterogeneity in lysosomes, in terms of their composition, function and positioning has come to be recognized. Despite this, there are gaps in knowledge of our understanding of the molecular basis of lysosome he...
miR-206 Regulates Hypoxia-Induced Mitophagy and Phenotypic Remodeling in Yak Pulmonary Artery Smooth Muscle Cells [0.03%]
miR-206通过调节藏羚羊肺动脉平滑肌细胞缺氧诱导的线粒体自噬及表型转换发挥作用
Pengfei Zhao,Shanshan Yang,Pengqiang Wei et al.
Pengfei Zhao et al.
Hypoxia drives pulmonary artery smooth muscle cells (PASMCs) proliferation and phenotypic remodeling, processes central to vascular adaptation. Yaks, native to high-altitude environments, provide a natural model for studying cellular respon...
Distinct signaling mechanisms and proteome phenotypes are elicited by compartment-specific genetic defects of copper homeostasis [0.03%]
铜稳态隔室特异性基因缺陷引发不同的信号转导机制和蛋白质组表型
Alicia R Lane,Nadia Gonzalez,Avanti Gokhale et al.
Alicia R Lane et al.
Impairments to the complex machinery regulating copper homeostasis lead to neurodevelopmental diseases, demonstrating the importance of copper for neuronal health and maintenance. The exact mechanisms by which the brain responds to copper d...