AP-3 and the V-ATPase Modulate CTP Synthase Assembly Through Spatial Association at the Yeast Vacuole [0.03%]
AP-3和V-ATP酶通过空间关联在酵母液泡中调节CTPS组装
Michaela McCright,Mitchell Leih,Ayla Nack et al.
Michaela McCright et al.
The compartmentalization of metabolic enzymes into membraneless filaments termed cytoophidia represents a conserved regulatory mechanism, exemplified by cytidine triphosphate synthase (CTPS), which assembles into pH-sensitive cytoophidia in...
The ESCRT-0 protein HRS regulates hepatocellular lipid droplet catabolism [0.03%]
ESCRT-0蛋白HRS调控肝细胞脂滴分解代谢
Mathilda M Willoughby,Ankit Shroff,Bridget E Crossman et al.
Mathilda M Willoughby et al.
Lipid droplets (LDs) are dynamic organelles that regulate lipid storage and metabolism pathways central to metabolic liver disease. LD turnover occurs in part through lysosomal catabolism (lipophagy), whereby LDs are delivered to lysosomes ...
OsTIR1(F74G) Expression Controls Basal and Auxin-Induced Degradation Rates of the AID System in Yeast [0.03%]
OsTIR1(F74G)表达控制酵母AID系统的基础和生长素诱导的降解速率
Julius A Fülleborn,Silke R Vedelaar,Andrei Seica et al.
Julius A Fülleborn et al.
The auxin-inducible degron (AID) system is widely used to conditionally deplete proteins in yeast, where the plant hormone auxin promotes OsTIR1-mediated degradation of AID-tagged proteins. However, "basal" degradation of AID-tagged protein...
Devika Andhare,Michael J Ragusa
Devika Andhare
Membrane tethering is essential for the generation of organelle contact sites, the catabolic process of autophagy and to anchor incoming vesicles to their target membranes before vesicle fusion. While membrane tethering is critical for cell...
Beyond Transport: Lysosomal solute carriers as orchestrators of immune signaling [0.03%]
超越运输：溶酶体转运蛋白在免疫信号传导中的协调作用
Daniel J Netting,Sergio Grinstein,Adriana R Mantegazza
Daniel J Netting
Solute carriers (SLCs) are the most abundant family of transmembrane transporters. They transport solutes such as amino acids, nucleosides and ions across membranes, regulating their cytosolic availability and maintaining homeostasis within...
The SAF-A/HNRNPU ATPase and RGG domains are important for XIST RNA localization, nuclear dynamics, RNA splicing, and cell proliferation [0.03%]
SAF-A/HNRNPU 的ATP酶和RGG结构域对XIST RNA定位、核动力学、RNA剪接和细胞增殖很重要
Judith A Sharp,Rachael Thomas,Emily Sparago et al.
Judith A Sharp et al.
The SAF-A/HNRNPU gene encodes an abundant nuclear protein conserved throughout vertebrates, and is mutated in individuals with HNRNPU syndrome, a neurological human disease. SAF-A is important for maintaining lncRNA localization, splicing, ...
A role for LIMA1 in the assembly of actin bundle-supported protrusions [0.03%]
LIMA1在肌动蛋白束支撑突起装配中的作用
Jennifer B Silverman,Kianna L Robinson,Su Min Hong et al.
Jennifer B Silverman et al.
Actin bundle-supported membrane protrusions contribute to a range of physiological functions across cell types. An interesting case is the tuft cell, which assembles exaggerated microvillus-like protrusions that support chemosensory functio...
Divisome and elongasome organisation in the genome-reduced obligate intracellular bacterium Orientia tsutsugamushi [0.03%]
施氏立克次体基因组缩减的细胞分裂和生长复合物组织架构研究
Suthida Chuenklin,Elizabeth Harris,Owen Somhorst et al.
Suthida Chuenklin et al.
Cell elongation and cytokinesis are mediated by two large multi-protein complexes in rod shaped bacteria: the elongasome and divisome. These membrane-associated complexes ultimately recruit peptidoglycan cell wall remodeling and synthesis m...
Sphingolipid regulation by yeast Mdm1 supports adaptive remodeling of the methionine transporter Mup1 [0.03%]
酵母Mdm1通过调控鞘脂来支持蛋氨酸转运蛋白Mup1的适应性重塑
Daniel Adebayo,Eseiwi Obaseki,Kashvi Vasudeva et al.
Daniel Adebayo et al.
Membrane lipid composition influences endocytic remodeling of nutrient transporters, yet how lipid metabolism is spatially coordinated to support sustained adaptation to nutrient limitations remains unclear. Here, we investigated whether th...
Yeast Ribosomal Protein Rpl32 Modulates Ribosome Biogenesis, Ribosome Stability and the Cell Cycle [0.03%]
酿酒酵母核糖体蛋白RPL32调控核糖体生物合成、核糖体稳定性和细胞周期
Stephen M Doris,Elizabeth S Noblin,Raphyel Rosby et al.
Stephen M Doris et al.
How does the cell coordinate its two major activities of cell growth and cell division? To explore this, we have genetically depleted yeast ribosomal protein Rpl32 of the 60S ribosomal subunit, which is an essential protein for cell prolife...