Epistemological parameters in the recent era of nuclear organization and function [0.03%]
近期核组织和功能领域的认识论参数
Thoru Pederson
Thoru Pederson
The sweeping progress in the nuclear organization-function field over the past two decades constitutes a major advance, to be sure. This work significantly impacts molecular, cell and developmental biology and has uncovered numerous clinica...
A role for the Stentor syntaxin protein in post-wound cell survival [0.03%]
Stentor.syntaxin蛋白在伤口后的细胞存活中的作用
Ambika V Nadkarni,Ulises Diaz,Ramon Rodriguez et al.
Ambika V Nadkarni et al.
Wound repair is an essential biological process that occurs both in tissues and single cells. In free-living single-celled ciliates such as Stentor coeruleus, rapid repair from wounds is necessary to heal breaches to the plasma membrane, wh...
Clearance and secretion of α-synuclein by RTN3L-mediated endoplasmic reticulum autophagy [0.03%]
RTN3L介导的内质网自噬清除和α-突触核蛋白分泌
Yihong Ye,Kamal Kumar,Yue Xu et al.
Yihong Ye et al.
The misfolding and aggregation of α-synuclein (α-syn), an abundant synaptic protein, leads to the pathogenesis of Parkinson's disease and related synucleinopathies. The cell-to-cell propagation of seeding-competent α-syn is initiated by ...
Kinesin-3 KIF1A functions as a diligent worker and its functionality is regulated by the ubiquitin-proteasome system [0.03%]
动力蛋白kif1a的功能由泛素-蛋白酶体系统调控
Jesse Cisneros Solis,Lynne Blasius,Kristen J Verhey
Jesse Cisneros Solis
Long-distance intracellular transport is driven by motor proteins that walk along microtubule tracks. The fate of the motor protein after transport is unclear. Classically, motor proteins have been thought to function as Diligent Workers (D...
Nuclear morphology and chromatin compaction modulate T cell cytoskeletal remodeling and immune synapse formation [0.03%]
核形态和染色质压缩可调节T细胞细胞骨架重塑及免疫突触形成
Ivan Rey-Suarez,Aashli Pathni,Frank Fazekas et al.
Ivan Rey-Suarez et al.
T cell activation induces a rapid reorganization of the actin cytoskeleton, facilitating cell spreading on antigen-presenting cells (APCs). As the nucleus, the cell's largest organelle, constrains cell shape changes, its mechanical properti...
Integrative Chemical Genetics Platform Identifies Condensate Modulators Linked to Neurological Disorders [0.03%]
整合化学遗传平台识别与神经疾病相关的凝聚体调节剂
Dylan Poch,Chandrayee Mukherjee,Sunanda Mallik et al.
Dylan Poch et al.
Dysregulation of biomolecular condensates is implicated across multiple neurological disorders. However, approaches to systematically identify their modulators remain limited. Here we expand the utility of MLF2 as a versatile condensate bio...
Wenfan Ke,Miki Fujioka,James B Jaynes et al.
Wenfan Ke et al.
We discuss the origins of three models for the structure of chromosomes in multi-cellular animals: CTCF/cohesin loop extrusion, compartments and boundary-boundary pairing. We then review what is known about the properties of TAD (topologica...
Conserved and Divergent Modes of Substrate Interaction Define Selective Localizations and Functions of a Cdc14 Phosphatase [0.03%]
底物相互作用的保守与分歧模式界定了Cdc14磷酸酶的选择性定位及其功能
Jun-Song Chen,Alaina H Willet,Lesley A Turner et al.
Jun-Song Chen et al.
Cdc14 phosphatases share conserved catalytic domains and enzymatic mechanisms. Despite functioning in disparate biological processes across eukaryotes, Cdc14 enzymes localize to analogous cellular structures from yeast to human cells. It re...
Dimerization of the centriolin-like protein Nud1 governs spindle pole body inheritance in budding yeast [0.03%]
中心体样蛋白Nud1的二聚化可调控芽殖酵母细胞分裂时子代中心粒的遗传状态
Kai Zhang,Katie Donnelly-Sharon,Rolf Sternglanz et al.
Kai Zhang et al.
Centrosome duplication is intrinsically asymmetric, creating an old and new copy, and this difference is used to guide fate decisions during both proliferation and differentiation. The budding yeast centrosome equivalent, the spindle pole b...
Non-muscle Myosin II acts as a negative feedback mediator to control cell contraction dynamics in adherent cells [0.03%]
非肌肉肌球蛋白II作为负反馈介体控制附着细胞收缩动力学
Carolin Gierse,Jennifer Hanemann,Leif Dehmelt
Carolin Gierse
Pulsatile cell contraction dynamics play a crucial role in tissue and cell morphogenesis. Previously, we identified a signal network in adherent mammalian cells, that can transduce mechanical signals via cell contraction pulses, which are g...