Sequestration of the exocytic SNARE Psy1 into multiprotein nodes reinforces polarized morphogenesis in fission yeast [0.03%]
分泌SNARE Psy1 在多蛋白节点中的隔离通过增强分裂酵母中极性化的形态发生来发挥作用
Kristi E Miller,Joseph O Magliozzi,Noelle A Picard et al.
Kristi E Miller et al.
Polarized morphogenesis is achieved by targeting or inhibiting growth in distinct regions. Rod-shaped fission yeast cells grow exclusively at their ends by restricting exocytosis and secretion to these sites. This growth pattern implies the...
Forty-five years of cGMP research in Dictyostelium: understanding the regulation and function of the cGMP pathway for cell movement and chemotaxis [0.03%]
Dictyostelium cGMP研究45年——对cGMP通路调控及功能的理解：细胞迁移和化学趋向性方面
Peter J M van Haastert,Ineke Keizer-Gunnink,Henderikus Pots et al.
Peter J M van Haastert et al.
In Dictyostelium, chemoattractants induce a fast cGMP response that mediates myosin filament formation in the rear of the cell. The major cGMP signaling pathway consists of a soluble guanylyl cyclase sGC, a cGMP-stimulated cGMP-specific pho...
Yeast Nst1 is a novel component of P-bodies and is a specific suppressor of proteasome base assembly defects [0.03%]
酿酒酵母Nst1是P体的新组分，并且是蛋白酶体底座装配缺陷的特异性抑制因子
Chin Leng Cheng,Michael K Wong,Mark Hochstrasser
Chin Leng Cheng
Proteasome assembly utilizes multiple dedicated assembly chaperones and is regulated by signaling pathways that respond to diverse stress conditions. To discover new factors influencing proteasome base assembly, we screened a tiled high-cop...
Mff oligomerization is required for Drp1 activation and synergy with actin filaments during mitochondrial division [0.03%]
线粒体分裂过程中MFF寡聚化诱导Drp1活化并与其与肌动蛋白纤维的协同作用相互促进
Ao Liu,Frieda Kage,Henry N Higgs
Ao Liu
Mitochondrial division is an important cellular process in both normal and pathological conditions. The dynamin GTPase Drp1 is a central mitochondrial division protein, driving constriction of the outer mitochondrial membrane (OMM). In mamm...
The receptor subunit Tom20 is dynamically associated with the TOM complex in mitochondria of human cells [0.03%]
人细胞线粒体中的受体亚基Tom20与TOM复合物动态相连
Maniraj Bhagawati,Tasnim Arroum,Niklas Webeling et al.
Maniraj Bhagawati et al.
The outer membrane translocase (TOM) is the import channel for nuclear-encoded mitochondrial proteins. The general import pore contains Tom40, Tom22, Tom5, Tom6, and Tom7. Precursor proteins are bound by the (peripheral) receptor proteins T...
Retraction [0.03%]
撤稿通知
Retraction of Publication
Molecular biology of the cell. 2021 Aug 1;32(16):1515. DOI:10.1091/mbc.E19-06-0326-corr 2021
Interplay of septin amphipathic helices in sensing membrane-curvature and filament bundling [0.03%]
Septin两亲性螺旋在感知膜曲率和丝状物聚集中的相互作用
Benjamin L Woods,Kevin S Cannon,Ellysa J D Vogt et al.
Benjamin L Woods et al.
The curvature of the membrane defines cell shape. Septins are GTP-binding proteins that assemble into heteromeric complexes and polymerize into filaments at areas of micron-scale membrane curvature. An amphipathic helix (AH) domain within t...
Coilin enhances phosphorylation and stability of DGCR8 and promotes miRNA biogenesis [0.03%]
Coilin通过促进DGCR8磷酸化和稳定来促进miRNA生成
Katheryn E Lett,Madelyn K Logan,Douglas M McLaurin et al.
Katheryn E Lett et al.
MicroRNAs (miRNAs) are ∼22 nt small noncoding RNAs that control gene expression at the posttranscriptional level through translational inhibition and destabilization of their target mRNAs. The biogenesis of miRNAs involves a series of proc...
Myosin light chain kinase-driven myosin II turnover regulates actin cortex contractility during mitosis [0.03%]
有丝分裂期间肌球蛋白轻链激酶驱动的肌球蛋白II更新调节actin皮层收缩力
Nilay Taneja,Sophie M Baillargeon,Dylan T Burnette
Nilay Taneja
Force generation by the molecular motor myosin II (MII) at the actin cortex is a universal feature of animal cells. Despite its central role in driving cell shape changes, the mechanisms underlying MII regulation at the actin cortex remain ...
Han Liao,Anushri Gaur,Claire Mauvais et al.
Han Liao et al.
Accumulating evidence indicates that increased ribosome biogenesis is a hallmark of cancer. It is well established that inhibition of any steps of ribosome biogenesis induces nucleolar stress characterized by p53 activation and subsequent c...