A year since George Floyd [0.03%]
乔治弗洛伊德之死一周年
Derek A Applewhite
Derek A Applewhite
The murder of George Floyd sparked an awakening, long overdue, which reverberated throughout society. As science begins to acknowledge its role in perpetuating systematic racism, the voices of Black scientists, which have largely been absen...
Exploiting differential effects of actomyosin contractility to control cell sorting among breast cancer cells [0.03%]
利用肌动蛋白肌球蛋白收缩性的差异效应来控制乳腺癌细胞的分类
Alexander J Devanny,Michelle B Vancura,Laura J Kaufman
Alexander J Devanny
In order to gain a greater understanding of the factors that drive spatial organization in multicellular aggregates of cancer cells, we investigate the segregation patterns of 6 breast cell lines of varying degree of mesenchymal character d...
CANVS: an easy-to-use application for the analysis and visualization of mass spectrometry-based protein-protein interaction/association data [0.03%]
CANVS：一个易于使用的基于质谱的蛋白质相互作用/关联数据的分析和可视化的应用程序
Erick F Velasquez,Yenni A Garcia,Ivan Ramirez et al.
Erick F Velasquez et al.
The elucidation of a protein's interaction/association network is important for defining its biological function. Mass spectrometry-based proteomic approaches have emerged as powerful tools for identifying protein-protein interactions (PPIs...
A dual role for DNA binding by Runt in activation and repression of sloppy paired transcription [0.03%]
Runt通过结合DNA在sloppy paired转录激活和抑制中的双重作用
Lisa Prazak,Yasuno Iwasaki,Ah-Ram Kim et al.
Lisa Prazak et al.
This work investigates the role of DNA binding by Runt in regulating the sloppy paired 1 (slp1) gene and in particular two distinct cis-regulatory elements that mediate regulation by Runt and other pair-rule transcription factors during Dro...
Cdc7-mediated phosphorylation of Cse4 regulates high-fidelity chromosome segregation in budding yeast [0.03%]
CDC7介导的Cse4磷酸化调节出芽酵母中的高保真度染色体分离
Prashant K Mishra,Henry Wood,John Stanton et al.
Prashant K Mishra et al.
Faithful chromosome segregation maintains chromosomal stability as errors in this process contribute to chromosomal instability (CIN), which has been observed in many diseases including cancer. Epigenetic regulation of kinetochore proteins ...
MRX8, the conserved mitochondrial YihA GTPase family member, is required for de novo Cox1 synthesis at suboptimal temperatures in Saccharomyces cerevisiae [0.03%]
糖酵母菌中MRX8（线粒体YihA家族成员）是新合成Cox1在亚最佳温度的必需因素
Yash Verma,Upasana Mehra,Dharmendra Kumar Pandey et al.
Yash Verma et al.
The synthesis of Cox1, the conserved catalytic-core subunit of Complex IV, a multisubunit machinery of the mitochondrial oxidative phosphorylation (OXPHOS) system under environmental stress, has not been sufficiently addressed. In this stud...
RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery [0.03%]
RUSC2和WDR47通过拮抗调节kinesin-1依赖的ATG9A向细胞边缘的分布
Carlos M Guardia,Akansha Jain,Rafael Mattera et al.
Carlos M Guardia et al.
Autophagy-related protein 9 (ATG9) is a transmembrane protein component of the autophagy machinery that cycles between the trans-Golgi network (TGN) in the perinuclear area and other compartments in the peripheral area of the cell. In mamma...
KIF18B is a cell type-specific regulator of spindle orientation in the epidermis [0.03%]
KIF18B是表皮细胞分裂平面取向的调控因子
Rebecca S Moreci,Terry Lechler
Rebecca S Moreci
Proper spindle orientation is required for asymmetric cell division and the establishment of complex tissue architecture. In the developing epidermis, spindle orientation requires a conserved cortical protein complex of LGN/NuMA/dynein-dyna...
Resveratrol and related stilbene derivatives induce stress granules with distinct clearance kinetics [0.03%]
白藜芦醇及其相关茋衍生物可诱导产生不同消失速率的应激颗粒
Triana Amen,Anthony Guihur,Christina Zelent et al.
Triana Amen et al.
Stress granules (SGs) are ribonucleoprotein functional condensates that form under stress conditions in all eukaryotic cells. Although their stress-survival function is far from clear, SGs have been implicated in the regulation of many vita...
Pyk2 regulates cell-edge protrusion dynamics by interacting with Crk [0.03%]
Pyk2通过与Crk相互作用调节细胞边缘突起动力学
Nikola Lukic,Stefanie Lapetina,Hanna Grobe et al.
Nikola Lukic et al.
Focal adhesion kinase (FAK) is well established as a regulator of cell migration, but whether and how the closely related proline-rich tyrosine kinase 2 (Pyk2) regulates fibroblast motility is still under debate. Using mouse embryonic fibro...