Rafael Arrojo E Drigo
Rafael Arrojo E Drigo
β-Cells in the islet of Langerhans have a central role in maintaining energy homeostasis. Understanding the physiology of β-cells and other islet cells requires a deep understanding of their structural and functional organization, their i...
Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway [0.03%]
伊麦格林通过调节内质网稳态通路改善β细胞的凋亡
Jinghe Li,Ryota Inoue,Yu Togashi et al.
Jinghe Li et al.
The effects of imeglimin, a novel antidiabetes agent, on β-cell function remain unclear. Here, we unveiled the impact of imeglimin on β-cell survival. Treatment with imeglimin augmented mitochondrial function, enhanced insulin secretion, ...
César Fernández-de-Las-Peñas,Carlos Guijarro,Juan Torres-Macho et al.
César Fernández-de-Las-Peñas et al.
This study investigated the association of diabetes in patients who recovered from severe acute respiratory syndrome coronavirus 2 infection with the presence of long-term post-coronavirus disease (COVID) symptoms. A case-control study that...
Diabetes, Drug Treatment, and Mortality in COVID-19: A Multinational Retrospective Cohort Study [0.03%]
糖尿病、药物治疗与COVID-19死亡率：一项多国回顾性队列研究
Jennifer E Nyland,Nazia T Raja-Khan,Kerstin Bettermann et al.
Jennifer E Nyland et al.
Patients with type 2 diabetes mellitus (T2DM) are at increased risk of severe coronavirus disease 2019 (COVID-19) outcomes possibly because of dysregulated inflammatory responses. Glucose-regulating medications, such as glucagon-like peptid...
Multicenter Study
Diabetes. 2021 Dec;70(12):2903-2916. DOI:10.2337/db21-0385 2021
Contraction-Mediated Glucose Transport in Skeletal Muscle Is Regulated by a Framework of AMPK, TBC1D1/4, and Rac1 [0.03%]
收缩介导的骨骼肌葡萄糖转运由AMPK，TBC1D1/4和Rac1调控框架控制
Christian de Wendt,Lena Espelage,Samaneh Eickelschulte et al.
Christian de Wendt et al.
The two closely related RabGTPase-activating proteins (RabGAPs) TBC1D1 and TBC1D4, both substrates for AMPK, play important roles in exercise metabolism and contraction-dependent translocation of GLUT4 in skeletal muscle. However, the speci...
CD8+ T Cells Variably Recognize Native Versus Citrullinated GRP78 Epitopes in Type 1 Diabetes [0.03%]
在1型糖尿病中CD8+ T细胞可变识别天然的与瓜氨酸化的GRP78表位
Marie Eliane Azoury,Fatoumata Samassa,Mijke Buitinga et al.
Marie Eliane Azoury et al.
In type 1 diabetes, autoimmune β-cell destruction may be favored by neoantigens harboring posttranslational modifications (PTMs) such as citrullination. We studied the recognition of native and citrullinated glucose-regulated protein (GRP)...
Gene Panel Sequencing of Patients With Monogenic Diabetes Brings to Light Genes Typically Associated With Syndromic Presentations [0.03%]
单基因糖尿病患者基因组检测揭示了综合征相关基因
Cécile Saint-Martin,Delphine Bouvet,Mathilda Bastide et al.
Cécile Saint-Martin et al.
Gene panel sequencing (NGS) offers the possibility of analyzing rare forms of monogenic diabetes (MgD). To that end, 18 genes were analyzed in 1,676 patients referred for maturity-onset diabetes of the young genetic testing. Among the 307 p...
Syntaxin 4 Enrichment in β-Cells Prevents Conversion to Autoimmune Diabetes in Non-Obese Diabetic (NOD) Mice [0.03%]
syntaxin 4在β细胞中的富集可预防非肥胖糖尿病(NOD)小鼠发生自身免疫性糖尿病转换
Eunjin Oh,Erika M McCown,Miwon Ahn et al.
Eunjin Oh et al.
Syntaxin 4 (STX4), a plasma membrane-localized SNARE protein, regulates human islet β-cell insulin secretion and preservation of β-cell mass. We found that human type 1 diabetes (T1D) and NOD mouse islets show reduced β-cell STX4 express...
Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape [0.03%]
发炎的β细胞的长RNA测序和核糖体分析揭示了广泛的转录组景观
Sofia Thomaidou,Roderick C Slieker,Arno R van der Slik et al.
Sofia Thomaidou et al.
Type 1 diabetes (T1D) is an autoimmune disease characterized by autoreactive T cell-mediated destruction of the insulin-producing pancreatic β-cells. Increasing evidence suggest that the β-cells themselves contribute to their own destruct...
The Deterrence of Rapid Metabolic Decline Within 3 Months After Teplizumab Treatment in Individuals at High Risk for Type 1 Diabetes [0.03%]
特利珠单抗治疗后三个月内血糖代谢迅速下降的高危个体对1型糖尿病的威慑作用
Emily K Sims,David Cuthbertson,Kevan C Herold et al.
Emily K Sims et al.
End points that provide an early identification of treatment effects are needed to implement type 1 diabetes prevention trials more efficiently. To this end, we assessed whether metabolic end points can be used to detect a teplizumab effect...
Clinical Trial
Diabetes. 2021 Dec;70(12):2922-2931. DOI:10.2337/db21-0519 2021