Toward Data-Driven MODY Panels: Strong Evidence for NEUROD1 and PDX1, Limited Support for APPL1 and WFS1 [0.03%]
迈向数据驱动的MODY基因组分型：NEUROD1和PDX1为致病基因，APPL1和WFS1提供有限证据
Satoshi Yoshiji,Daisuke Tanaka
Satoshi Yoshiji
Proteogenomic Insights Into Type 1 Diabetes: Refining Biomarkers and Therapeutic Targets [0.03%]
基于蛋白组的1型糖尿病研究：改进生物标志物和治疗靶点
Estefany Maricielo Cubas Diaz,Danna Miley Fernández Moreno,Cesar H Saravia Paz Soldan
Estefany Maricielo Cubas Diaz
Distributed Control of Muscle Glucose Uptake: A Tribute to the Late Dr. David H. Wasserman by Revisiting a 2004 Diabetes Classic by Fueger et al [0.03%]
肌糖原摄取的分布式控制：通过重新审视Fueger等在2004年发表的经典文章向已故Wasserman博士致敬
Julio E Ayala
Julio E Ayala
The control of muscle glucose uptake (MGU) is distributed across delivery, transport, and phosphorylation of glucose. These steps have been defined as control points of MGU in vivo due to the application of isotopic tracer techniques to tra...
Metabolic Perturbations and Ectopic Fat Deposition in Men With Low Birth Weight: Effects of a 4-Week Carbohydrate Overfeeding Challenge [0.03%]
低出生体重男性碳水化合物摄入过量后的代谢紊乱及异常脂肪沉积响应研究
Charlotte Brøns,Line Ohrt Elingaard-Larsen,Louise Justesen et al.
Charlotte Brøns et al.
Low birth weight (LBW) is a risk factor for type 2 diabetes (T2D). We hypothesized that 4 weeks of carbohydrate overfeeding (COF) with +25% energy would unmask key T2D perturbations among 22 nonobese LBW men, including five with screen-dete...
Katharina Schormair,Jiawei Zhong,Laura D M Rico et al.
Katharina Schormair et al.
Adipocyte size is linked to insulin resistance and the risk of developing type 2 diabetes. We aimed to generate a surrogate method to estimate adipocyte size by measuring adipose tissue gene expression using quantitative real-time PCR (qRT-...
Pathobiology of Prediabetes: Understanding and Interrupting Progressive Dysglycemia and Associated Complications [0.03%]
糖尿病前期的病理生物学：理解并阻止血糖异常进展及相关并发症出现
Samuel Dagogo-Jack
Samuel Dagogo-Jack
Diabetes currently affects ∼37 million adults in the U.S. and 537 million people worldwide, with type 2 diabetes (T2D) accounting for 90%-95% of the diabetes burden. The transition from normal glucose regulation (NGR) to T2D is via an inte...
O-GlcNAcylation Stabilizes NEK7 to Drive Podocyte Pyroptosis in Diabetic Kidney Disease [0.03%]
O-GlcNAc酰化通过稳定NEK7促进糖尿病肾病足细胞pyroptosis
Wen Chen,Jiarong Liu,Yun Zou et al.
Wen Chen et al.
We identify threonine 302 as the critical O-GlcNAcylation site on NIMA-related kinase 7 (NEK7), which stabilizes NEK7 by inhibiting its proteasomal degradation, thereby enhancing NLRP3 inflammasome activation and podocyte pyroptosis in diab...
Caroline Miranda,Cristiano Santos,Johan Tolö et al.
Caroline Miranda et al.
Optical activation or δ-cells stimulate somatostatin secretion. δ-Cell depolarization evokes β-cell action potential firing and insulin release. δ-Cell activation results in islet-wide synchronized β-cell cytoplasmic free Ca2+ concentr...