Gestational Diabetes Mellitus Alters Placental Precursor mRNA Splicing [0.03%]
妊娠期糖尿病改变胎盘前体mRNA的剪接路径
Eden Engal,Adi Gershon,Shiri Melamed et al.
Eden Engal et al.
Gestational diabetes mellitus (GDM) causes hyperglycemia during pregnancy and adverse maternal and neonatal outcomes. Bulk placental gene expression has been reported largely unchanged. RNA sequencing of Norwegian and Chinese GDM placentas ...
Cerebrospinal Fluid Fatty Acids, Hypothalamic Inflammation, and Weight Loss in Human Obesity: A Longitudinal Study [0.03%]
人肥胖患者脑脊液脂肪酸、下丘脑炎症与体重减轻的纵向研究
Adriana Pané,Laura Videla,Àngels Calvet-Mirabent et al.
Adriana Pané et al.
Preclinical studies show that dietary or central administration of monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs) can reduce food intake, enhance energy expenditure, and attenuate hypothalamic inflammation (HI),...
Baseline Insulin Secretion Determines Response to Abatacept in Stage 1 Type 1 Diabetes [0.03%]
基线胰岛素分泌决定阿巴西普治疗1期糖尿病的效果
Alfonso Galderisi,Alice L J Carr,Peter Taylor et al.
Alfonso Galderisi et al.
We sought to investigate whether baseline insulin secretion (ϕtotal), quantified using the oral minimal model assessing β-cell function, could identify a subgroup of responders to abatacept (a cytotoxic T lymphocyte-associated protein 4 i...
Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic Score [0.03%]
一种1型糖尿病多祖先多基因评分的开发和验证
Aaron J Deutsch,Andrew S Bell,Dominika A Michalek et al.
Aaron J Deutsch et al.
Polygenic scores strongly predict type 1 diabetes risk, but most scores were developed in European-ancestry populations. In this study, we leveraged recent multiancestry genome-wide association studies to create a Type 1 Diabetes Multi-Ance...
Protection Against Type 1 Diabetes Development in Mice With 4E-BP2 Deletion [0.03%]
缺失4E-BP2的小鼠对1型糖尿病的抵抗作用
Valentina Pita-Grisanti,Flavia Leticia Martins Peçanha,Ruy A Louzada et al.
Valentina Pita-Grisanti et al.
Mammalian target of rapamycin complex 1 (mTORC1) signaling is essential to β-cell mass, function, and adaptive immunity; however, its specific downstream mediators in type 1 diabetes (T1D) remain poorly defined. We investigated eukaryotic ...
Obstructive Sleep Apnea, Resting Heart Rate, and Glycemic Variability in Adults With Maturity-Onset Diabetes of the Young [0.03%]
阻塞性睡眠呼吸暂停、静息心率与年轻人发病糖尿病成年患者的血糖波动关系
Marilyn Arosemena,Karishma Chopra,Maria V Salguero et al.
Marilyn Arosemena et al.
Obstructive sleep apnea (OSA) is a common condition strongly linked to increased cardiovascular risk and poor glycemic control. Little is known about OSA, cardiovascular risk, and glycemia in maturity-onset diabetes of the young (MODY), an ...
Killing of Human β-Cells by CD8+ T Cells Triggers Inflammatory Paracrine Signaling and Neighboring β-Cell Dysfunction [0.03%]
CD8⁺T细胞诱导的β细胞死亡通过炎性旁分泌信号引起邻近β细胞功能障碍
Masaya Oshima,Clémentine Halliez,Farah Kobaisi et al.
Masaya Oshima et al.
In type 1 diabetes, CD8+ T cells destroy pancreatic β-cells. Since most β-cells avoid direct T-cell contact, we asked whether bystander effects drive their dysfunction and loss. We asked whether CD8+ T cells can damage β-cells indirectly...
miR-432 Exacerbates Obesity-Induced Dysregulation of Glucose and Lipid Homeostasis [0.03%]
miR-432通过加重肥胖引起的葡萄糖和脂质稳态失调促进肥胖的发展
Cuizhe Wang,Yanting Hou,Meixiu Zhang et al.
Cuizhe Wang et al.
miRNAs are key regulators of metabolic homeostasis, yet their role in obesity-associated dysfunction remains incompletely understood. Here, we identify miR-432 as a driver of systemic metabolic dysregulation. Serum miRNA profiling revealed ...
β-Hydroxybutyrylation Links Ketone Metabolism to Mitochondrial Remodeling in Diabetic Cardiomyopathy [0.03%]
3-羟基丁酰化将酮体代谢与糖尿病心肌病中的线粒体重塑相联系
Haoran Jing,Meixin Shi,Ye Wang et al.
Haoran Jing et al.
Diabetic cardiomyopathy (DbCM) is characterized by metabolic remodeling and energetic stress independent of coronary artery disease. Increased reliance on fatty acid and ketone body metabolism has been observed in DbCM, but the regulatory m...
Additive Effects of Dorzagliatin and Glucagon-Like Peptide-1 Receptor Agonism in a Novel Mouse Model of GCK-MODY and in Obese db/db Mice [0.03%]
新型GCK成熟型糖尿病和肥胖db/db小鼠模型中葡萄糖激酶激活剂多扎gluca和GLP-1受体激动剂的协同增效作用
Shadai Salazar,Luis Fernando Delgadillo-Silva,Priscila Carapeto et al.
Shadai Salazar et al.
Glucokinase (GK) deficiency can drive maturity-onset diabetes of the young (GCK-MODY) in heterozygotes and permanent neonatal diabetes in homozygotes. We describe a hypomorphic Gck allele that results in aberrant splicing in islets and live...