Proteogenomic Discovery of Novel Open Reading Frames With HLA Immune Presentation on Human β-Cells [0.03%]
人β细胞的蛋白质基因组学发现新的开放阅读框及其人类白细胞抗原呈递特性
Kathryn Walters,Roberto Castro-Gutierrez,Soumyadeep Sarkar et al.
Kathryn Walters et al.
We developed a cell type-specific proteogenomic approach to reveal novel or unannotated open reading frames (nuORFs) using transcriptomics, ribosomal profiling, and proteomic analysis of human pancreatic β-cells using stem cell-derived β-...
Effects of Dorzagliatin, a Glucokinase Activator, on α- and β-Cell Function in Individuals With Impaired and Normal Glucose Tolerance [0.03%]
葡萄糖激酶激活剂多扎格列艾汀对糖耐量异常和正常人群α细胞和β细胞功能的影响
Zhengli Bai,Ke Wang,Tiffany Yau et al.
Zhengli Bai et al.
Dorzagliatin is a dual-acting allosteric glucokinase (GCK) activator that increases β-cell glucose sensitivity and second-phase insulin in GCK monogenic diabetes of the young. Actions of dorzagliatin on α- and β-cell function in normal a...
Proinflammatory Stress Activates Neutral Sphingomyelinase 2-Based Generation of a Ceramide-Enriched β-Cell EV Subpopulation [0.03%]
促炎应激激活基于中性鞘氨醇磷脂酶2的 ceramide富集β细胞外泌体亚群生成
Jerry Xu,Irene Amalaraj,Andre De Oliveira et al.
Jerry Xu et al.
Mechanisms connecting β-cell stress to extracellular vesicle (EV) cargo and diabetes are poorly defined. Does β-cell inflammatory stress engage neutral sphingomyelinase 2 (nSMase2)-dependent EV formation to generate ceramide-enriched smal...
Novel Approach for Assessing Outcomes of Type 1 Diabetes Prevention Trials Over a Fixed Time Interval [0.03%]
固定时间间隔的一型糖尿病预防研究结局评估的新方法
Emily K Sims,William E Russell,David Cuthbertson et al.
Emily K Sims et al.
Challenges in time to event type 1 diabetes (T1D) prevention trial design can yield negative results even for treatments that may actually improve disease pathology. We evaluated whether a binary metabolic end point for 12-month change from...
Ameth N Garrido,Song-Yang Zhang,Kyla Bruce et al.
Ameth N Garrido et al.
Upper small intestine lipid infusion increases kidney, hepatic, and plasma growth differentiation factor 15 (GDF15) levels in chow but not high-fat rats. Upper small intestine lipid infusion lowers food intake in chow but not high-fat rats....
Metabolome-Wide Mendelian Randomization and Observational Study Reveal Causal Links Between Circulating Metabolites and Youth-Onset Type 2 Diabetes [0.03%]
代谢组范围的孟德尔随机化和观察性研究揭示循环代谢物与青年发病2型糖尿病的因果关系
Kaossarath Fagbemi,Raphael Avocegamou,Nahid Yazdanpanah et al.
Kaossarath Fagbemi et al.
Metabolism is key in the pathogenesis of type 2 diabetes in both children and adults, and large-scale metabolomic studies offer a unique source for discovery of biomarkers for these conditions. Leveraging human genetics, we explored whether...
Tessa M Cacciottolo,Katherine Lawler,Kevin M Méndez-Acevedo et al.
Tessa M Cacciottolo et al.
In this study, we investigated a consanguineous family in whom normal-weight individuals had hepatic steatosis and cirrhosis. Using whole-exome sequencing we found two rare homozygous variants in the glucagon receptor (GCGR) gene that coseg...
SIRT6 Is a Key Regulator of Pancreatic β-Cell Survival and Function During Aging [0.03%]
SIRT6是衰老过程中胰腺β细胞存活和功能的关键调节因子
Jimin Park,Sandali D Lokuge,Menghao Huang et al.
Jimin Park et al.
Pancreatic β-cell function declines with age, but the underlying mechanism is poorly understood. In this study, we attempted to address how to reverse β-cell aging. Our data showed that sirtuin 6 (SIRT6) overexpression can reduce age-asso...
Investigating Late-Stage Diabetic Retinopathy: A Long-term Analysis of Vascular Changes in the Streptozotocin-Induced Mouse Model [0.03%]
链脲佐菌素诱导的小鼠模型糖尿病视网膜病变晚期血管改变的长期研究分析
Madison E Weiss,Milin J Patel,Brandon H Watts et al.
Madison E Weiss et al.
We use the newly developed fluorescence angiography with dual fluorescence imaging method to longitudinally investigate associations between vascular leakage and visual acuity during early-, intermediate-, and late-stage diabetic retinopath...
Islet Autoantibody Testing as Type 1 Diabetes Early Detection Enters Mainstream Health Care [0.03%]
胰岛自身抗体检测：1型糖尿病早期筛查步入常规医疗体系
Kathleen M Gillespie
Kathleen M Gillespie
Editorial
Diabetes. 2025 Sep 1;74(9):1466-1468. DOI:10.2337/dbi25-0016 2025