Developmental Timing of High-Fat Diet Exposure Impacts Glucose Homeostasis in Mice in a Sex-Specific Manner [0.03%]
高脂饮食暴露的发育时期以性别特异性的方式影响小鼠的血糖稳态
Maria M Glavas,Ann Y Lee,Ian Miao et al.
Maria M Glavas et al.
We previously demonstrated that male, but not female, Swiss Webster mice are susceptible to diabetes, with incidence increased by early overnutrition and high-fat diet (HFD). In this study, we investigated how HFD in Swiss Webster males and...
Different Effects of Lifestyle Intervention in High- and Low-Risk Prediabetes: Results of the Randomized Controlled Prediabetes Lifestyle Intervention Study (PLIS) [0.03%]
生活方式干预在高危和低危糖尿病前期的不同效果：随机对照糖尿病前期生活干预研究(PLIS)的结果
Andreas Fritsche,Robert Wagner,Martin Heni et al.
Andreas Fritsche et al.
Lifestyle intervention (LI) can prevent type 2 diabetes, but response to LI varies depending on risk subphenotypes. We tested whether individuals with prediabetes with low risk (LR) benefit from conventional LI and individuals with high ris...
Randomized Controlled Trial
Diabetes. 2021 Dec;70(12):2785-2795. DOI:10.2337/db21-0526 2021
Activation of HIF1α Rescues the Hypoxic Response and Reverses Metabolic Dysfunction in the Diabetic Heart [0.03%]
HIF1α的激活可挽救糖尿病心脏中的缺氧反应并逆转其代谢功能障碍
Maria da Luz Sousa Fialho,Ujang Purnama,Kaitlyn M J H Dennis et al.
Maria da Luz Sousa Fialho et al.
Type 2 diabetes (T2D) impairs hypoxia-inducible factor (HIF)1α activation, a master transcription factor that drives cellular adaptation to hypoxia. Reduced activation of HIF1α contributes to the impaired post-ischemic remodeling observed...
Spatial Regulation of Reactive Oxygen Species via G6PD in Brown Adipocytes Supports Thermogenic Function [0.03%]
棕色脂肪细胞中通过G6PD对活性氧的空間調節支持產熱功能
Jee Hyung Sohn,Yul Ji,Chang-Yun Cho et al.
Jee Hyung Sohn et al.
Reactive oxygen species (ROS) are associated with various roles of brown adipocytes. Glucose-6-phosphate dehydrogenase (G6PD) controls cellular redox potentials by producing NADPH. Although G6PD upregulates cellular ROS levels in white adip...
Chromogranin A Deficiency Confers Protection From Autoimmune Diabetes via Multiple Mechanisms [0.03%]
通过多种机制，肾上腺来源的激素皮质颗粒素A缺乏对自身免疫性糖尿病具有保护作用
Neetu Srivastava,Hao Hu,Anthony N Vomund et al.
Neetu Srivastava et al.
Recognition of β-cell antigens by autoreactive T cells is a critical step in the initiation of autoimmune type1 diabetes. A complete protection from diabetes development in NOD mice harboring a point mutation in the insulin B-chain 9-23 ep...
Coxsackievirus B Vaccines Prevent Infection-Accelerated Diabetes in NOD Mice and Have No Disease-Inducing Effect [0.03%]
柯萨奇病毒B型疫苗可以预防NOD小鼠的感染加速糖尿病且不具有疾病诱导效应
Virginia M Stone,Marta Butrym,Minna M Hankaniemi et al.
Virginia M Stone et al.
Enteroviruses, including the Coxsackievirus Bs (CVB), have been implicated as causal agents in human type 1 diabetes. Immunization of at-risk individuals with a CVB vaccine provides an attractive strategy for elucidating the role of CVBs in...
Effect of Systemic Hypertension on Peripapillary RNFL Thickness in Patients With Diabetes Without Diabetic Retinopathy [0.03%]
糖尿病视网膜病变患者血压对视盘周围RNFL厚度的影响
Min-Woo Lee,Gi-Seok Park,Hyung-Bin Lim et al.
Min-Woo Lee et al.
Type 2 diabetes mellitus (T2DM) and hypertension (HTN) are both relatively common systemic diseases and cause damage to the retina, such as inner retina reduction and microvascular impairment. The purpose of this study was to identify perip...
Hepatocytic Activating Transcription Factor 3 Protects Against Steatohepatitis via Hepatocyte Nuclear Factor 4α [0.03%]
活化蛋白转录因子3通过肝细胞核因子4α来预防steatohepatitis
Yanyong Xu,Shuwei Hu,Kavita Jadhav et al.
Yanyong Xu et al.
Activating transcription factor 3 (ATF3) has been shown to play an important role in HDL metabolism; yet, the role of hepatocytic ATF3 in the development of steatohepatitis remains elusive. Here we show that adenoassociated virus-mediated o...
β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet-Fed Mice [0.03%]
SENP1 β细胞敲除小鼠对肠促胰素的反应降低及高脂饮食喂养小鼠口服葡萄糖耐量恶化
Haopeng Lin,Nancy Smith,Aliya F Spigelman et al.
Haopeng Lin et al.
SUMOylation reduces oxidative stress and preserves islet mass at the expense of robust insulin secretion. To investigate a role for the deSUMOylating enzyme sentrin-specific protease 1 (SENP1) following metabolic stress, we put pancreas/gut...
Leukocyte Counts and T-Cell Frequencies Differ Between Novel Subgroups of Diabetes and Are Associated With Metabolic Parameters and Biomarkers of Inflammation [0.03%]
糖尿病新亚型的白细胞计数和T细胞频率差异及其与代谢参数及炎症标志物的相关性研究
Jacqueline M Ratter-Rieck,Haifa Maalmi,Sandra Trenkamp et al.
Jacqueline M Ratter-Rieck et al.
Frequencies of circulating immune cells are altered in those with type 1 and type 2 diabetes compared with healthy individuals and are associated with insulin sensitivity, glycemic control, and lipid levels. This study aimed to determine wh...