Genome-Wide Association Study of Hypoglycemia in Adults With Diabetes in the Million Veteran Program [0.03%]
退伍军人百万人基因组计划中关于糖尿病成人低血糖的全基因组关联研究
Sridharan Raghavan,Elizabeth Litkowski,Aubrey Jensen et al.
Sridharan Raghavan et al.
Genetic variants associated with hypoglycemia risk in individuals with medication-treated diabetes have not been evaluated genome-wide. The specific question we asked was whether common genetic variants are associated with hypoglycemia amon...
Systems Biology and Functional Assessments of Human iPSC-Cardiomyocyte Models of Insulin Resistance Capture Key Hallmarks of Diabetic Cardiomyopathy [0.03%]
系统生物学和功能评估鉴定出人多能干细胞源心脏细胞模型中的胰岛素抵抗糖尿病心肌病的关键特征
Ryan D Carter,Ujang Purnama,Marcos Castro-Guarda et al.
Ryan D Carter et al.
Human-centric cardiac models are needed that recapitulate mechanistic and functional changes in the type 2 diabetic myocardium for understanding disease pathogenesis and developing new therapies. Using human induced pluripotent stem cell-de...
Multiomics Integration of Epigenetics, Proteomics, and Metabolomics Identifies Putative Drug Targets and Improves Early Prediction for Diabetes [0.03%]
表观遗传学、蛋白质组学和代谢组学的多组学整合鉴定潜在药物靶点并改善糖尿病早期预测能力
Wenran Li,Yingyu Cheng,Aoyuan Cui et al.
Wenran Li et al.
A total of 175 CpGs, 29 proteins, and 93 metabolites were identified as associated with diabetes, among which 43 CpGs and 25 metabolites were validated in an independent cohort. Causal and mediation analyses revealed 20 biomarkers and 190 s...
β-Cell Neogenesis From the Pancreatic Ductal Epithelium Revealed Dynamically by Long-term Intravital Imaging [0.03%]
长时间活体显微镜动态揭示胰管上皮源性β细胞新生
Brandon Watts,Isabella Altilio,Óscar Alcázar et al.
Brandon Watts et al.
The adult pancreas' capacity to regenerate endocrine cells through ductal neogenesis has been disputed based on some pulse-chase lineage-tracing designs; however, no model described thus far has enabled the real-time study of regeneration i...
Serum Metabolomics Reveals Potential Differences in Gut Microbiota-Associated Metabolites in Twins Discordant for Type 1 Diabetes [0.03%]
血清代谢组学揭示了一型糖尿病发病双胞胎间肠道菌群相关代谢物的差异
Elizabeth R Flammer,Michael W Christopher,Esabella R Powers et al.
Elizabeth R Flammer et al.
We believed this cohort of twins discordant for type 1 diabetes (T1D) would allow for control over genetic variability to examine environmental factors. We aimed to identify differences in microbial and microbiota-associated metabolites in ...
Mechanistic Insights Into Postprandial Insulin-Glucagon Interactions and Their Impact on Glucose Flux After Protein-Glucose Coingestion in Humans [0.03%]
人体餐后胰岛素-胰高糖素相互作用的机制见解及其对蛋白质-葡萄糖同服后血糖通量的影响
Giang M Dao,Chistopher S Shaw,Andrew C Betik et al.
Giang M Dao et al.
Despite stimulating glucagon secretion, the mechanisms by which protein ingestion lowers glucose excursions remain unclear. We investigated this using the triple stable isotope glucose tracer technique to measure postprandial glucose fluxes...
Heterogeneity in Phenotype and Early Metabolic Response to Lifestyle Interventions in Type 2 Diabetes in China Using a Tree-Like Representation [0.03%]
利用树状图对中国2型糖尿病患者表型和生活方式干预早期代谢反应异质性的研究
Yi Ding,Qi Zhou,Youjin Jiang et al.
Yi Ding et al.
Deciphering the heterogeneity of type 2 diabetes in prognosis and treatment effect is essential. We used a novel dimensionality reduction approach to describe the type 2 diabetes phenotype continuum and visualize the difference in lifestyle...
Proinflammatory Cytokines Mediate Pancreatic β-Cell-Specific Alterations to Golgi Integrity via iNOS-Dependent Mitochondrial Inhibition [0.03%]
促炎症细胞因子通过iNOS依赖性线粒体抑制介导高尔基复合体β细胞特异性改变
Sandra E Blom,Palin R Narsian,Riley M Behan-Bush et al.
Sandra E Blom et al.
Type 1 diabetes (T1D) is caused by the selective autoimmune ablation of pancreatic β-cells. Emerging evidence reveals β-cell secretory dysfunction arises early in T1D development and may contribute to diseases etiology; however, the under...
Application of Dental Pulp Stem Cell-Derived Intracellular Vesicles for Diabetic Wound Healing [0.03%]
牙髓间充质干细胞来源的细胞内小体在糖尿病创面修复中的应用研究
Pengcheng Pang,Yonghao Liu,Haicheng Song et al.
Pengcheng Pang et al.
Diabetic wounds represent a significant clinical and economic burden, affecting both patients and health care systems. While current therapeutic approaches, such as negative pressure wound therapy, offer benefits, their limitations necessit...
Cell Type-Specific Expression of Long Noncoding RNAs in Human Diabetic Kidneys Identifies TARID as a Key Regulator of Podocyte Function [0.03%]
人糖尿病肾脏特异性表达的长链非编码RNA鉴定出TARID为足细胞功能的关键调控因子
Juliette A de Klerk,Roderick C Slieker,Wilson C Parker et al.
Juliette A de Klerk et al.
This study provides a resource for kidney (cell type-specific) long noncoding (lnc)RNA expression and demonstrates the importance of lncRNAs in renal health. We identified 174 cell type-specific lncRNAs in the human kidney, with 54 showing ...