Differential effects of nicotinic acetylcholine receptor stimulation on negative occasion setting [0.03%]
胆碱能受体对负向偶合设置的不同的影响作用
Jill E MacLeod,Megan M Vucovich,David J Bucci
Jill E MacLeod
We have previously shown that nicotine enhances learning in a negative occasion setting task in which rats are trained to distinguish between two different trial types. During reinforced trials, a target stimulus (a tone) is presented and i...
Dopamine activity in the lateral anterior hypothalamus modulates AAS-induced aggression through D2 but not D5 receptors [0.03%]
侧下丘脑背内侧核多巴胺D2受体通过调节伏隔核信号通路参与攻击行为的调控
Jared J Schwartzer,Richard H Melloni Jr
Jared J Schwartzer
Treatment with anabolic-androgenic steroids (AAS) throughout adolescence facilitates offensive aggression in Syrian hamsters. In the anterior hypothalamus (AH), the dopaminergic neural system undergoes alterations after repeated exposure to...
Valence dependent asymmetric release of norepinephrine in the basolateral amygdala [0.03%]
基底外侧杏仁核去甲肾上腺素的释放具有阀值和不对称性
Erica J Young,Cedric L Williams
Erica J Young
Emerging evidence from literature on humans suggests the valence of emotionally laden environmental stimuli may dictate whether amygdala activation is greater in one hemisphere relative to the contralateral side. However, only a paucity of ...
Spatial learning based on boundaries in rats is hippocampus-dependent and prone to overshadowing [0.03%]
基于边界的空间学习依赖海马区且易受抑制的影响
Murray R Horne,Mihaela D Iordanova,John M Pearce
Murray R Horne
In three experiments, rats were required to find a submerged platform by referring to the boundaries of a circular swimming pool. In the first experiment, rats with lesions of the hippocampus were impaired at finding the hidden platform, le...
Motor cortex injury has different behavioral and anatomical effects in early and late adolescence [0.03%]
儿童和青少年时期 motor cortex损伤的不同行为和解剖效应
Farshad Nemati,Bryan Kolb
Farshad Nemati
Although there are many studies investigating the effects of early cortical injury on brain and behavioral development in laboratory animals, there are virtually no studies examining the effects of cortical injury in adolescence. The purpos...
An abrupt developmental shift in callosal modulation of sleep-related spindle bursts coincides with the emergence of excitatory-inhibitory balance and a reduction of somatosensory cortical plasticity [0.03%]
背侧前连合在感觉皮层抑制性-兴奋性平衡建立及可塑性下降过程中扮演关键角色
Amy Jo Marcano-Reik,Tuhina Prasad,Joshua A Weiner et al.
Amy Jo Marcano-Reik et al.
Transecting the corpus callosum of postnatal day (P)1-6 rats disinhibits the production of spindle bursts (SBs) within primary somatosensory cortex (S1), most notably during periods of sleep-related myoclonic twitching. Here we investigated...
Familiarity-based stimulus generalization of conditioned suppression in rats is dependent on the perirhinal cortex [0.03%]
熟悉性刺激泛化引起大鼠习得抑制行为依赖腹内侧颞叶皮层功能
Jasper Robinson,Emma J Whitt,Rachel R Horsley et al.
Jasper Robinson et al.
We report that bilateral, excitoxic lesions of the perirhinal cortex attenuate rats' familiarity-based stimulus generalization. After surgery, rats were preexposed either to 2 auditory stimuli (A and B) or to only 1 auditory stimulus (B). F...
Teri M Furlong,Sindy Cole,Adam S Hamlin et al.
Teri M Furlong et al.
Pavlovian fear conditioning depends on prediction error, or the discrepancy between actual and expected outcomes. We used immunohistochemistry, neuronal tract tracing, and reversible inactivation to study the role of prefrontal cortex and t...
Pattern separation deficits may contribute to age-associated recognition impairments [0.03%]
模式分离缺陷可能导致年龄相关的识别障碍
Sara N Burke,Jenelle L Wallace,Saman Nematollahi et al.
Sara N Burke et al.
Normal aging is associated with impairments in stimulus recognition. In the current investigation, object recognition was tested in adult and aged rats with the standard spontaneous object recognition (SOR) task or two variants of this task...
Serotonin impairs copulation and attenuates ejaculation-induced glutamate activity in the medial preoptic area [0.03%]
五羟色胺削弱交配并降低中前脑核射精诱发的谷氨酸活性
Juan M Dominguez,Elaine M Hull
Juan M Dominguez
The medial preoptic area (MPOA) is critical for male sexual behavior. Glutamate is released in the MPOA of male rats during copulation, and increasing glutamate levels by reverse dialysis of glutamate uptake inhibitors facilitates mating. C...