Exploring prefrontal cortical memory mechanisms with eyeblink conditioning [0.03%]
利用条件眨眼反应探索前额皮层的记忆机制
Craig Weiss,John F Disterhoft
Craig Weiss
Several studies in nonhuman primates have shown that neurons in the dorsolateral prefrontal cortex have activity that persists throughout the delay period in delayed matching to sample tasks, and age-related changes in the microcolumnar org...
Proinflammatory activity and the sensitization of depressive-like behavior during maternal separation [0.03%]
母体隔离期间的促炎活性和类似抑郁行为的敏化作用
Michael B Hennessy,Kristopher D Paik,Jessica D Caraway et al.
Michael B Hennessy et al.
When guinea pig pups are isolated for a few hours in a novel environment, they exhibit a distinctive passive behavioral response that appears to be mediated by proinflammatory activity. Recently, we observed that pups separated on two conse...
Set shifting in a rodent model of attention-deficit/hyperactivity disorder [0.03%]
注意缺陷多动障碍动物模型中的任务切换能力研究
Amy C Chess,Brittany E Raymond,Ira G Gardner-Morse et al.
Amy C Chess et al.
Two experiments compared spontaneously hypertensive rats (SHRs; a rodent model of attention-deficit/hyperactivity disorder) and Wistar rats (a normoactive control strain), on the acquisition of a set-shifting strategy. In Experiment 1, SHRs...
Comparative Study
Behavioral neuroscience. 2011 Jun;125(3):372-82. DOI:10.1037/a0023571 2011
Developmental and withdrawal effects of adolescent AAS exposure on the glutamatergic system in hamsters [0.03%]
雄性仓鼠青春期使用类固醇对谷氨酸能系统产生的发育和戒断效应
Maria Carrillo,Lesley A Ricci,Richard H Melloni
Maria Carrillo
In the Syrian hamster (Mesocricetus auratus) glutamate activity has been implicated in the modulation of adolescent anabolic-androgenic steroid (AAS)-induced aggression. The current study investigated the time course of adolescent AAS-induc...
Rat prefrontal dopamine and cognitive control: impaired and enhanced conflict performance [0.03%]
大鼠前额叶多巴胺与认知控制：冲突表现受损及改善
Josephine E Haddon,Simon Killcross
Josephine E Haddon
It has been proposed that the cognitive dysfunction observed in patients with schizophrenia reflects a failure in cognitive control, in particular an inability to use task-relevant information to guide behavior. Using a prefrontal-dependent...
The effect of catecholaminergic depletion within the prelimbic and infralimbic medial prefrontal cortex on recognition memory for recency, location, and objects [0.03%]
多巴胺能神经元在海马脑区损伤对近期记忆 归位和认物的影响作用研究
Andrew J D Nelson,Molly T Cooper,Karen E Thur et al.
Andrew J D Nelson et al.
There is good evidence that the medial prefrontal cortex (mPFC) is involved in different aspects of recognition memory. However, the mPFC is a heterogeneous structure, and the contribution of the prelimbic (PL) and infralimbic (IL) cortices...
Molecular modulation of prefrontal cortex: rational development of treatments for psychiatric disorders [0.03%]
前额叶皮层的分子调控：精神疾病治疗的理性开发路径
Nao J Gamo,Amy F T Arnsten
Nao J Gamo
Dysfunction of the prefrontal cortex (PFC) is a central feature of many psychiatric disorders, such as attention deficit hyperactivity disorder (ADHD), posttraumatic stress disorder (PTSD), schizophrenia, and bipolar disorder. Thus, underst...
Attentional effects of lesions to the anterior cingulate cortex: how prior reinforcement influences distractibility [0.03%]
ACC损伤的认知效应：既往强化影响注意力的方式
Lori A Newman,Jill McGaughy
Lori A Newman
Morphological changes in the anterior cingulate cortex are found in subjects with schizophrenia, attention deficit hyperactivity disorder, and obsessive-compulsive disorder. These changes are hypothesized to underlie the impairments these i...
Outcome-specific satiety reveals a deficit in context-outcome, but not stimulus- or action-outcome, associations in aged Tg2576 mice [0.03%]
老龄Tg2576小鼠情境-结果、但非刺激-结果或行动-结果关联缺陷的特异性 satiety检测结果显示
Mariah J Lelos,Rhian S Thomas,Emma J Kidd et al.
Mariah J Lelos et al.
The onset of Alzheimer's disease (AD) is often accompanied by changes in emotion, motivation, and goal-directed behavior. The production of beta-amyloid is thought to be a major and early contributor to the pathogenesis of AD. The present s...
Maternal defense is modulated by beta adrenergic receptors in lateral septum in mice [0.03%]
小鼠侧隔膜β肾上腺素能受体调节母性防御行为
Melissa-Ann L Scotti,Grace Lee,Stephen C Gammie
Melissa-Ann L Scotti
Maternal defense (offspring protection) is a critical and highly conserved component of maternal care in mammalian systems that involves dramatic shifts in a female's behavioral response to social cues. Numerous changes occur in neuronal si...