Biological sex influences the contribution of sign-tracking and anxiety-like behavior toward remifentanil self-administration [0.03%]
性别差异影响了寻求标志行为和焦虑样行为向雷米芬太尼自主给药的贡献作用
Alicia Zumbusch,Anna Samson,Chloe Chernoff et al.
Alicia Zumbusch et al.
Most people sample addictive drugs, but use becomes disordered in only a small minority. Two important factors that influence susceptibility to addiction are individual differences in personality traits and biological sex. The influence of ...
Ilias Chaibi,Otmane Bouchatta,Mohamed Bennis et al.
Ilias Chaibi et al.
Aggression is a complex social behavior that evolved in the context of defending a territory, fighting for limited resources, and competing for mates and protection. Although aggression considered as a negative or undesirable emotion is an ...
Chemogenetic activation of lateral habenula accelerates the extinction of the appetitive conditioned responses [0.03%]
化学遗传活化侧缰核加速 appetitive 条件反应的消退
Dong-Hee Kim,Bo-Ryoung Choi,In-Beom Jin et al.
Dong-Hee Kim et al.
A previous study reported lateral habenula (LHb) lesions decelerated appetitive extinction. Therefore, we examined whether LHb activation accelerated appetitive extinction. In this study, rats received appetitive Pavlovian conditioning, pai...
Effect of striatal dopamine on Pavlovian bias. A large [¹⁸F]-DOPA PET study [0.03%]
纹状体多巴胺对帕伏洛夫偏见的影响。一个大型的[¹⁸F]-DOPA正电子发射断层扫描研究
Ping Chen,Dirk E M Geurts,Jessica I Määttä et al.
Ping Chen et al.
Interaction between Pavlovian and instrumental control systems is key for adaptive motivated behavior, but also plays an important role in various neuropsychiatric disorders, including depression, addiction, and anxiety. Here, we employed t...
The effects of time horizon and guided choices on explore-exploit decisions in rodents [0.03%]
时间范围和引导选择对啮齿动物探索开发决策的影响
Siyu Wang,Blake Gerken,Julia R Wieland et al.
Siyu Wang et al.
Humans and animals have to balance the need for exploring new options with exploiting known options that yield good outcomes. This tradeoff is known as the explore-exploit dilemma. To better understand the neural mechanisms underlying how h...
Memory and anxiety-like behavior of rats in the plus-maze discriminative avoidance task: Role of serotonergic transmission in the basolateral amygdala [0.03%]
在加号迷宫辨别回避任务中大鼠的回忆和类似焦虑的行为：基底外侧杏仁核中五羟色胺传递的作用
João P F Kurita,Anderson H F F Leão,Vinicius S Bioni et al.
João P F Kurita et al.
Optimal levels of anxiety are critical to memory consolidation, but maladaptive anxiety can disrupt memory acquisition. Serotonergic activity within the amygdala influences both anxiety-like behavior and aversive memory consolidation. To ev...
Xueyan Zhang,Jun Li,Xiaomei Li
Xueyan Zhang
Previous studies have reported the importance of the precuneus in mediating metacognition and the prefrontal cortex in decision-making tasks. However, the mechanisms underlying metacognition remain to be fully elucidated. N-acetyl aspartate...
Pair housing does not alter incubation of craving, extinction, and reinstatement after heroin self-administration in female and male rats [0.03%]
雌雄大鼠自施海洛因后的渴求、消退和复燃的孵育过程不受共栖影响
Kelle E Nett,Ryan T LaLumiere
Kelle E Nett
Evidence suggests that single housing in rats acts as a chronic stressor, raising the possibilities that it contributes to measures of heroin craving and that pair housing ameliorates such measures. This study aimed to determine whether pai...
Primary rewards and aversive outcomes have comparable effects on attentional bias [0.03%]
正向奖励和负向结果对注意力偏差有相似的影响
Haena Kim,Brian A Anderson
Haena Kim
Attention is biased toward stimuli previously associated with reward. The same is true for aversive conditioning; stimuli previously associated with an aversive outcome also bias attention, suggesting that motivational salience guides atten...
Divergent effects of oral cannabis oil extracts marketed as C. indica or C. sativa on exertion of cognitive effort in rats [0.03%]
作为C.indica或C.sativa销售的口服大麻油提取物的发散效果对大鼠认知努力的影响
Hannah G Brodie,Brett A Hathaway,Andrew Li et al.
Hannah G Brodie et al.
The main psychoactive compound within the cannabis plant, Δ9-tetrahydrocannabinol (THC), is thought to drive both the sensation of "high" and the cognitive impairments associated with cannabis consumption. Researchers keen to understand ho...