Marios Chris Panayi,Geoffrey Schoenbaum
Marios Chris Panayi
Impaired insight in substance use disorder has been argued to reflect a global deficit in using cognitive models to mentally simulate possible future outcomes. The process of mentally simulating outcomes allows us to understand our beliefs ...
Gonzalo P Urcelay
Gonzalo P Urcelay
Although numerous behavioral constructs have been proposed to account for anxiety disorders, how these disorders develop within an individual has been difficult to predict. In this perspective, I selectively review clinical and experimental...
Beyond reconsolidation: The need for a broad theoretical approach in clinical translations of research on retrieval-induced plasticity [0.03%]
超越再巩固：在临床转化研究中进行检索诱导可塑性理论的广泛性思考
K Matthew Lattal
K Matthew Lattal
Experimental findings showing that retrieved memories are labile and vulnerable to disruption have led to important theoretical ideas at a basic science level that have been applied to the clinic at a translational level. At a theoretical l...
Chronic stressor exposure impairs extinction of fear in adolescent rats and has associated effects on perineuronal nets and parvalbumin interneurons [0.03%]
慢性应激暴露会影响青春期大鼠的恐惧消退并影响神经外网和钙结合蛋白神经元
Elizabeth A Virakorn,Rick Richardson,Kathryn D Baker
Elizabeth A Virakorn
Adolescents, both human and nonhuman, exhibit impairments in the extinction of learned fear, an effect that is exacerbated, at least in rodents, by exposure to chronic stress. However, we have little understanding of the mechanisms underlyi...
Prediction, perception, and psychosis: Application of associative learning theories to schizophrenia research [0.03%]
预测、感知与精神病前阶段：联想学习理论在精神分裂症研究中的应用
Riria Suzuki,Yutaka Kosaki
Riria Suzuki
In recent years, there have been significant advances in our understanding of the positive symptoms of schizophrenia, such as hallucinations and delusions. This progress has been significantly aided by the use of associative learning-based ...
The role of midbrain dopamine cells projecting to the insular cortex in mediated performance: Implications for animal models of reality testing [0.03%]
中脑多巴胺细胞向脑岛皮质投射在中介表现中的作用：对动物现实检验模型的含义
Benjamin R Fry,Victoria Fex,Akira Sawa et al.
Benjamin R Fry et al.
A growing body of literature indicates that mediated learning techniques have specific utility for tapping into reality testing in animal models of neuropsychiatric illness. In particular, recent work has shown that animal models that recap...
Marie-H Monfils,Hongjoo J Lee,Marissa Raskin et al.
Marie-H Monfils et al.
Here, we describe the efforts we dedicated to the challenge of modifying entrenched emotionally laden memories. In recent years, through a number of collaborations and using a combination of behavioral, molecular, and computational approach...
Translational approaches to the neurobiological study of conditional discrimination and inhibition: Implications for psychiatric disease [0.03%]
条件性辨别和抑制的神经生物学研究的转化方法及其对精神疾病的意义
Susan Sangha,Jacklynn M Fitzgerald
Susan Sangha
There is a growing number of studies investigating discriminatory fear conditioning and conditioned inhibition of fear to assess safety learning, in addition to extinction of cued fear. Despite all of these paradigms resulting in a reductio...
Impact of supplementation with omega-3 fatty acids after maternal dietary deficiency on adolescent anxiety and microglial morphology [0.03%]
母体饮食缺乏后补充ω-3脂肪酸对青少年焦虑和小胶质细胞形态的影响
Alina P Bogachuk,David S Jacobs,Bita Moghaddam
Alina P Bogachuk
Dietary maternal deficiency in omega-3 polyunsaturated fatty acids (n-3 PUFA) is a potential risk factor for the development of anxiety and other mood disorders in children and adolescents. Here, we used a previously characterized maternal ...
N-tert-butoxycarbonyl-methylenedioxymethamphetamine, an methylenedioxymethamphetamine derivative, exhibits rewarding and reinforcing effects by increasing dopamine levels [0.03%]
N-叔丁氧羰基-甲基二氧杂色胺的成瘾性及其通过增加多巴胺水平发挥作用的机理的研究
Dong-Hyun Youn,Cheolmin Jo,Jin Mook Kim et al.
Dong-Hyun Youn et al.
An N-protected methylenedioxymethamphetamine (MDMA), N-tert-butoxycarbonyl-3,4-methylenedioxymethamphetamine (t-BOC-3,4-MDMA), contains tert-butoxycarbonyl and can remain undetected in the illicit drug market. It is a new type of precursor ...