Distinct competitive impacts of palatability of taste stimuli on sampling dynamics during a preference test [0.03%]
味觉刺激的适口性对偏爱测试中采样动力学产生不同的竞争影响
Benjamin Ballintyn,John Ksander,Donald B Katz et al.
Benjamin Ballintyn et al.
Food or taste preference tests are analogous to naturalistic decisions in which the animal selects which stimuli to sample and for how long to sample them. The data acquired in such tests, the relative amounts of the alternative stimuli tha...
Muscimol inactivation of dorsal striatum in young and aged male rats does not affect paired associates learning performance [0.03%]
muscimol失活背侧纹状体不影响年轻和年老的大鼠配对联想学习的表现
Samantha M Smith,Elena L Garcia,Anna Montelongo et al.
Samantha M Smith et al.
Improving cognitive health for older adults requires understanding the neurobiology of age-related cognitive decline and the mechanisms underlying preserved cognition in old age. During spatial learning tasks, aged humans and rodents shift ...
A single dose of ketamine enhances early life stress-induced aggression with no effect on fear memory, anxiety-like behavior, or depression-like behavior in mice [0.03%]
单剂量氯胺酮增强小鼠早期生活应激诱导的攻击行为而不影响恐惧记忆、类似焦虑和类似抑郁的行为
Caitlyn J Bartsch,Sophia Aaflaq,Jessica T Jacobs et al.
Caitlyn J Bartsch et al.
Ketamine is a dissociative anesthetic that has been shown to have antidepressant effects in humans and has been proposed as a potential treatment for mood disorders such as posttraumatic stress disorder and aggression. However, previous stu...
The motivational role of the ventral striatum and amygdala in learning from gains and losses [0.03%]
伏隔核与杏仁核在从获利和损失中学习过程中的动机作用
Craig A Taswell,Miriam Janssen,Elisabeth A Murray et al.
Craig A Taswell et al.
The ventral striatum (VS) and amygdala are two structures often implicated as essential structures for learning. The literature addressing the contribution of these areas to learning, however, is not entirely consistent. We propose that the...
Ketamine facilitates appetitive trace conditioning in mice: Further evidence for abnormal stimulus representation in schizophrenia model animals [0.03%]
氯胺酮诱发小鼠追加性条件作用现象：精神分裂症模型动物的进一步证据
Riria Suzuki,Yutaka Kosaki
Riria Suzuki
Recent studies indicated that positive symptoms of schizophrenia, such as hallucination and delusion, can be modeled using Pavlovian conditioning procedures. Various schizophrenia model animals exhibit abnormally strong associative activati...
Divergent risky decision-making and impulsivity behaviors in Lewis rat substrains with low genetic difference [0.03%]
遗传差异较小的Lewis品系大鼠中发散性的冒险决策和冲动行为研究
Daniel B K Gabriel,Anna E Liley,Hunter T Franks et al.
Daniel B K Gabriel et al.
Substance use disorder (SUD) is associated with a cluster of cognitive disturbances that engender vulnerability to ongoing drug seeking and relapse. Two of these endophenotypes-risky decision-making and impulsivity-are amplified in individu...
Prefrontal and medial temporal interactions in memory functions in the rhesus monkey [0.03%]
猕猴记忆功能中的前额叶和海马区的相互作用
Laura A Welke,Tara L Moore,Douglas L Rosene et al.
Laura A Welke et al.
Both the medial temporal lobe and the dorsolateral prefrontal cortex have been implicated in learning and memory. However, it has been difficult to ascertain the degree to which the two structures are dependent on each other or interact in ...
The medial preoptic area and its projections to the ventral tegmental area and the periaqueductal gray are activated in response to social play behavior in juvenile rats [0.03%]
大侧脑室前区及其投射到中脑边缘核团的通路在幼年大鼠社交嬉戏行为中的激活效应
Changjiu Zhao,Lauren V Riters
Changjiu Zhao
The medial preoptic area (MPOA) is well known for its role in sexual and maternal behaviors. This region also plays an important role in affiliative social behaviors outside reproductive contexts. We recently demonstrated that the MPOA is a...
Maternal repetitive hypoxia prior to mating confers epigenetic resilience to memory impairment in male progeny [0.03%]
孕前重复性缺氧可赋予子代雄鼠记忆损伤表观遗传适应性抵抗响应反应
Emrey E Broyles,David H Corell,Jeffrey M Gidday
Emrey E Broyles
We showed previously in a mouse model of vascular cognitive impairment and dementia involving chronic cerebral hypoperfusion (CCH) that repetitive hypoxic conditioning (RHC) of both parents results in the epigenetic, intergenerational trans...
Examination of onset trajectories and persistence of binge-like eating behavior in mice after intermittent palatable food exposure [0.03%]
间断摄入美味食物后小鼠暴食样行为的发生和持续性研究
Britny A Hildebrandt,Hayley Fisher,Susanne E Ahmari
Britny A Hildebrandt
Binge eating is a persistent behavior associated with a chronic course of illness and poor treatment outcomes. While clinical research is unable to capture the full course of binge eating, preclinical approaches offer the opportunity to exa...