Characterization of neurotoxic effects of NMDA and the novel neuroprotection by phytopolyphenols in mice [0.03%]
新型植物多酚类物质对谷氨酸钠神经毒作用的保护效应及其机理研究
Chen Chang-Mu,Lin Jen-Kun,Liu Shing-Hwa et al.
Chen Chang-Mu et al.
Excitotoxicity plays a major role in various neurological disorders. In this study, we explored the behavioral and neurotoxic effects of intraventricular NMDA administration in mice. After NMDA injection, acute seizures were followed by imp...
Human navigation that requires calculating heading vectors recruits parietal cortex in a virtual and visually sparse water maze task in fMRI [0.03%]
基于fMRI的虚拟视觉稀疏水迷宫实验中需要计算heading向量的人类导航激活顶叶皮层
Paul F Rodriguez
Paul F Rodriguez
Spatial navigation in the real-world is a complex task that involves many functions, such as landmark identification, orientation, and the calculation of heading vectors. This study uses a 2 x 2 experimental design with fMRI to isolate mnem...
Effects of multiple daily nicotine administrations on pre- and post-nicotine circadian activity episodes in rats [0.03%]
多次尼古丁处理对大鼠给药前和给药后昼夜活动节律的影响
Andrea G Gillman,Ann E K Kosobud,William Timberlake
Andrea G Gillman
Administration of a single daily dose of nicotine has been shown to entrain circadian activity episodes both preceding and following the administration time that persist for several days after drug administration ceases. The present study t...
Moriel Zelikowsky,Michael S Fanselow
Moriel Zelikowsky
In Pavlovian overshadowing, a stimulus that predicts a biologically important event reduces conditioning to another, equally predictive stimulus. We tested the effects of an opioid antagonist and dopamine agonist on the ability of a salient...
Operant learning requires NMDA-receptor activation in the anterior cingulate cortex and dorsomedial striatum, but not in the orbitofrontal cortex [0.03%]
操作性学习需要N-甲基-D天冬氨酸受体在前扣带回和背内侧纹状体活化，而非额叶眶部
Brenda L McKee,Ann E Kelley,Hannah R Moser et al.
Brenda L McKee et al.
Previous research has shown that corticostriatal N-methyl-D-aspartate receptor (NMDAR) activation is necessary for operant learning. NMDAR activation induces plasticity-related intracellular signaling processes leading to gene expression, w...
Dipesh Chaudhury,Laura Manella,Adolfo Arellanos et al.
Dipesh Chaudhury et al.
Habituation is a simple form of memory, yet its neurobiological mechanisms are only beginning to be understood in mammals. In the olfactory system, the neural correlates of habituation at a fast experimental timescale involving very short i...
Conditioning with masked stimuli affects the timecourse of skin conductance responses [0.03%]
掩蔽刺激的条件作用影响皮肤电反应的时间进程
Nicholas L Balderston,Fred J Helmstetter
Nicholas L Balderston
In Pavlovian fear conditioning, an aversive unconditional stimulus (UCS) is repeatedly paired with a neutral conditional stimulus (CS). As a consequence, the subject begins to show conditional responses (CRs) to the CS that indicate expecta...
Self-administered cocaine causes long-lasting increases in impulsive choice in a delay discounting task [0.03%]
自我管理可卡因会在延迟折扣任务中导致长时间的冲动选择增加
Ian A Mendez,Nicholas W Simon,Nigel Hart et al.
Ian A Mendez et al.
Cocaine use is associated with high levels of impulsive choice (preference for immediate over delayed rewards), but it is not clear whether cocaine use causes elevated impulsive choice, or whether elevated impulsive choice is solely a predi...
Differential responses to serotonin receptor ligands in an impulsive-aggressive phenotype [0.03%]
冲动攻击型表型对5-ht受体配体的不同反应
M Catalina Cervantes,Emily A Biggs,Yvon Delville
M Catalina Cervantes
Offensive aggression in golden hamsters is inhibited by 5-hydroxytryptamine (5-HT)1A receptors and facilitated by 5-HT3 receptor activation. As such, we sought to determine whether these receptors function similarly between animals expressi...
Arrest of adult hippocampal neurogenesis in mice impairs single- but not multiple-trial contextual fear conditioning [0.03%]
小鼠成年海马神经发生受阻损害一次性但不影响多次条件恐惧反应式的 CONDITIONALFear Conditioning)学习任务的能力
Michael R Drew,Christine A Denny,Rene Hen
Michael R Drew
The role of adult hippocampal neurogenesis in contextual fear conditioning (CFC) is debated. Several studies demonstrated that blocking adult hippocampal neurogenesis in rodents impairs CFC, while several other studies failed to observe an ...