Retrieval and savings of contextual fear memories across an extended retention interval in juvenile and adult male and female rats [0.03%]
未成年和成年雄性和雌性大鼠延长保持间隔后情境恐惧记忆的提取与节省
Natalie Odynocki,Zerah Isaacs,Andrew M Poulos
Natalie Odynocki
Adult rodents exhibit an exceptional ability to retrieve context fear memories across lengthy retention intervals. In contrast, these memories established in younger rodents are susceptible to significant forgetting. The present study aimed...
Negative attributes of mixed-valence memories strengthen over long retention intervals and the degree of enhancement is predicted by individual differences in state anxiety [0.03%]
混合价态记忆的消极属性在长时间保留间隔中增强且增强的程度由个体状态焦虑差异预测
Louis D Matzel,Dylan W Crawford,Julia Bond et al.
Louis D Matzel et al.
Memories are multifaceted and can simultaneously contain positive and negative attributes. Here, we report that negative attributes of a mixed-valence memory dominate long-term recall. To induce a mixed-valence memory, running responses wer...
Prelimbic cortex inactivation prevents ABA renewal based on stress state [0.03%]
纹状回失活预防基于压力状态的ABA更新
Callum M P Thomas,Mark E Bouton,John T Green
Callum M P Thomas
Our recent research suggests that the interoceptive state associated with stress can function as a contextual stimulus for operant behavior. In the present experiment, we investigated the role of the rodent prelimbic cortex (PL), a brain re...
Optogenetic inhibition of the caudal substantia nigra inflates behavioral responding to uncertain threat and safety [0.03%]
optogenetically抑制尾部黑质神经元使不确定威胁和安全的行为反应过度化
Kristina M Wright,Shannon Cieslewski,Amanda Chu et al.
Kristina M Wright et al.
Defensive responding is adaptive when it approximates the current threat but maladaptive when it exceeds the current threat. Here we asked if the substantia nigra, a region consistently implicated in reward, is necessary to show appropriate...
Can the resting state peak alpha frequency explain the relationship between temporal resolution power and psychometric intelligence? [0.03%]
静息态顶峰alpha频率能否解释心理测量智力和时间分辨能力之间的关系？
Lisa M Makowski,Stefan J Troche
Lisa M Makowski
The temporal resolution power (TRP) hypothesis states that individuals with higher TRP, as reflected by a higher performance on several psychophysical timing tasks, perform better on intelligence tests due to their ability to process inform...
Kamin blocking is disrupted by low-dose ketamine in mice: Further implications for aberrant stimulus processing in schizophrenia [0.03%]
低剂量氯胺酮会破坏小鼠的Kamin抑制作用：精神分裂症异常刺激处理的进一步含义
Riria Suzuki,Kenji Yamaguchi,Yutaka Kosaki
Riria Suzuki
Previous studies have shown that low doses of ketamine, an N-methyl-D-aspartate receptor antagonist, produce aberrantly strong internal representations of associatively activated but absent stimuli in humans and nonhuman animals, suggesting...
Electric barrier-induced voluntary abstinence reduces alcohol seeking in male, but not female, iP rats [0.03%]
电击围栏诱导的自愿戒酒可降低雄性而非雌性近交系大鼠对酒精的寻求行为
Xavier J Maddern,Andrew J Lawrence,Erin J Campbell
Xavier J Maddern
Maintaining abstinence and preventing relapse are key to the successful recovery from alcohol use disorder. There are two main ways individuals with alcohol use disorder abstain from alcohol use: forced (e.g., incarceration) and voluntary. ...
Hippocampal and amygdala volumes vary with residential proximity to toxicants at Birmingham, Alabama's 35th Avenue Superfund site [0.03%]
美国阿拉巴马州伯明翰市35大道超级基金项目周边有毒物质暴露与海马体和杏仁核体积变化的关系研究
Kristen N Buford,Carly R Snidow,Tasha G Curiel et al.
Kristen N Buford et al.
Exposure to environmental toxicants have serious implications for the general health and well-being of children, particularly during pivotal neurodevelopmental stages. The Environmental Protection Agency's (EPA) Superfund program has identi...
Proteome analysis indicates participation of the dorsal hippocampal formation in fear-motivated memory in a time-dependent manner [0.03%]
蛋白组分析表明海马背侧结构以时间依赖的方式参与了由恐惧引起的记忆形成
Renan Barretta Gaiardo,Amanda Paula Pedroso,Eliane Beraldi Ribeiro et al.
Renan Barretta Gaiardo et al.
Our previous behavioral and molecular data indicate a central role of the dorsal hippocampal formation (dHF) in recent conditioned lick suppression memory. The purpose of this study was to investigate the role of the dHF in recent and remot...
Xiaolin Qiao,Lauren Wolters,James D Howard
Xiaolin Qiao
Mental representations of stimuli that are not physically present are critical for a range of cognitive capacities, including perception, memory, and learning. Overly robust mental representations, however, can contribute to hallucinations ...