Tools for computational analysis of moving boundary problems in cellular mechanobiology [0.03%]
细胞机械生物学中移动边界问题的计算分析工具
Kathleen T DiNapoli,Douglas N Robinson,Pablo A Iglesias
Kathleen T DiNapoli
A cell's ability to change shape is one of the most fundamental biological processes and is essential for maintaining healthy organisms. When the ability to control shape goes awry, it often results in a diseased system. As such, it is impo...
Gabrielle A Dotson,Charles W Ryan,Can Chen et al.
Gabrielle A Dotson et al.
Generating needed cell types using cellular reprogramming is a promising strategy for restoring tissue function in injury or disease. A common method for reprogramming is addition of one or more transcription factors that confer a new funct...
Thermoregulation: A journey from physiology to computational models and the intensive care unit [0.03%]
从生理学到计算模型再到重症监护室的体温调节之旅
Kristijan Skok,Maja Duh,Andraž Stožer et al.
Kristijan Skok et al.
Thermoregulation plays a vital role in homeostasis. Many species of animals as well as humans have evolved various physiological mechanisms for body temperature control, which are characteristically flexible and enable a fine-tuned spatial ...
Mammalian cell and tissue imaging using Raman and coherent Raman microscopy [0.03%]
拉曼及相干拉曼显微镜在细胞与组织成像中的应用研究进展——哺乳动物细胞与组织的拉曼及相干拉曼显微成像技术
Anthony A Fung,Lingyan Shi
Anthony A Fung
Direct imaging of metabolism in cells or multicellular organisms is important for understanding many biological processes. Raman scattering (RS) microscopy, particularly, coherent Raman scattering (CRS) such as coherent anti-Stokes Raman sc...
Regulating cellular cyclic adenosine monophosphate: "Sources," "sinks," and now, "tunable valves" [0.03%]
调控细胞内环腺苷酸：“来源”、“去路”，以及现在“可调阀门”
Michael Getz,Padmini Rangamani,Pradipta Ghosh
Michael Getz
A number of hormones and growth factors stimulate target cells via the second messenger pathways, which in turn regulate cellular phenotypes. Cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger that facilitates numerous s...
Edwin K Silverman,Harald H H W Schmidt,Eleni Anastasiadou et al.
Edwin K Silverman et al.
Network Medicine applies network science approaches to investigate disease pathogenesis. Many different analytical methods have been used to infer relevant molecular networks, including protein-protein interaction networks, correlation-base...
Tilmann Glimm,Ramray Bhat,Stuart A Newman
Tilmann Glimm
We review the current state of mathematical modeling of cartilage pattern formation in vertebrate limbs. We place emphasis on several reaction-diffusion type models that have been proposed in the last few years. These models are grounded in...
Computational models to explore the complexity of the epithelial to mesenchymal transition in cancer [0.03%]
计算模型探究癌症上皮间质转化的复杂性
Marilisa Cortesi,Chiara Liverani,Laura Mercatali et al.
Marilisa Cortesi et al.
Epithelial to mesenchymal transition (EMT) is a complex biological process that plays a key role in cancer progression and metastasis formation. Its activation results in epithelial cells losing adhesion and polarity and becoming capable of...
Aspirin and the chemoprevention of cancers: A mathematical and evolutionary dynamics perspective [0.03%]
从数学和进化动态角度看待阿司匹林的化学预防癌症作用
Natalia L Komarova,C Richard Boland,Ajay Goel et al.
Natalia L Komarova et al.
Epidemiological data indicate that long-term low dose aspirin administration has a protective effect against the occurrence of colorectal cancer, both in sporadic and in hereditary forms of the disease. The mechanisms underlying this protec...
Sahak Z Makaryan,Colin G Cess,Stacey D Finley
Sahak Z Makaryan
Detailed, mechanistic models of immune cell behavior across multiple scales in the context of cancer provide clinically relevant insights needed to understand existing immunotherapies and develop more optimal treatment strategies. We highli...