Bioinspired and bioderived nanomedicine for inflammatory bowel disease [0.03%]
仿生和生物衍生的纳米药物在炎症性肠病中的应用
Rafaela Gazzi,Rita Gelli,Simone Aleandri et al.
Rafaela Gazzi et al.
Due to its chronic nature and complex pathophysiology, inflammatory bowel disease (IBD) poses significant challenges for treatment. The long-term therapies for patients, often diagnosed between the ages of 20 and 40, call for innovative str...
Theranostic nanoparticles for detection and treatment of pancreatic cancer [0.03%]
用于胰腺癌诊断和治疗的诊疗纳米颗粒
Happy Agarwal,Ryan C Bynum,Nada Saleh et al.
Happy Agarwal et al.
Pancreatic ductal adenocarcinoma (PDAC) is one of the most recalcitrant cancers due to its late diagnosis, poor therapeutic response, and highly heterogeneous microenvironment. Nanotechnology has the potential to overcome some of the challe...
Engineering magnetic nanosystem for TRPV1 and TRPV4 channel activation [0.03%]
工程磁性纳米系统激活TRPV1和TRPV4通道
Fang Yang,Yaqi Ma,Aoran Zhang et al.
Fang Yang et al.
Recently, physical tools for remotely stimulating mechanical force-sensitive and temperature-sensitive proteins to regulate intracellular pathways have opened up novel and exciting avenues for basic research and clinical applications. Among...
Chemoradiotherapy and nanomedicine: Drug mechanisms and delivery systems [0.03%]
化疗和放射治疗及纳米医药：药物机制和输送系统
Matthew Molinaro,David Skrodzki,Dipanjan Pan
Matthew Molinaro
Radiotherapy is an invaluable tool in the treatment of cancer. However, when used as a monotherapy, it fails to provide curative outcomes. Chemotherapy drugs are often included to boost the effects of radiation. Key classes of radiosensitiz...
Polymer-drug and polymer-protein conjugated nanocarriers: Design, drug delivery, imaging, therapy, and clinical applications [0.03%]
聚合物-药物和聚合物-蛋白质偶联纳米递送系统：设计、给药、成像、治疗及临床应用
Haochen Guo,Peng Mi
Haochen Guo
Polymer-drug conjugates and polymer-protein conjugates have been pivotal in the realm of drug delivery systems for over half a century. These polymeric drugs are characterized by the conjugation of therapeutic molecules or functional moieti...
Guanqing Yang,Jianxun Ding,Xuesi Chen
Guanqing Yang
The interplay between the tumor cells and their microenvironments is as inseparable as the relationship between "seeds" and "soil." The tumor microenvironments (TMEs) exacerbate malignancy by enriching malignant cell subclones, generating e...
Stemness, invasion, and immunosuppression modulation in recurrent glioblastoma using nanotherapy [0.03%]
纳米疗法在复发性胶质母细胞瘤中的应用：调节干细胞性、侵袭性和免疫抑制性
Shrita Sarkar,Jessica Greer,Nathaniel J Marlowe et al.
Shrita Sarkar et al.
The recurrent nature of glioblastoma negatively impacts conventional treatment strategies leading to a growing need for nanomedicine. Nanotherapeutics, an approach designed to deliver drugs to specific sites, is experiencing rapid growth an...
Nanozymes for biomedical applications: Multi-metallic systems may improve activity but at the cost of higher toxicity? [0.03%]
纳米酶的生物医学应用：多元金属体系或可提高活性，但可能增加毒性？
Thuong Phan-Xuan,Ben Breitung,Lea Ann Dailey
Thuong Phan-Xuan
Nanozymes are nanomaterials with intrinsic enzyme-like activity with selected advantages over native enzymes such as simple synthesis, controllable activity, high stability, and low cost. These materials have been explored as surrogates to ...
Tao Li,Yupeng Wang,Dongfang Zhou
Tao Li
Nanomedicines have significantly advanced the development of diagnostic and therapeutic strategies for various diseases, while they still encounter numerous challenges. Upon entry into the human body, nanomedicines interact with biomolecule...
Shifting paradigm in electrochemical biosensing matrices comprising metal organic frameworks and their composites in disease diagnosis [0.03%]
基于金属有机框架及其复合材料的电化学生物传感矩阵在疾病诊断中的应用及研究展望
Shubhangi,Divya,Sanjay K Rai et al.
Shubhangi et al.
Metal Organic Frameworks (MOFs) are an evolving category of crystalline microporous materials that have grabbed the research interest for quite some time due to their admirable physio-chemical properties and easy fabrication methods. Their ...