Drug Delivery Systems for Resiquimod to Control Myeloid-Derived Suppressor Cells in Cancer Immunotherapy [0.03%]
用于控制癌症免疫治疗中髓源性抑制细胞的Resiquimod递送系统
Yanying He,Yoon Yeo
Yanying He
Over the past decade, immunotherapy has emerged as the fourth pillar of cancer therapy, following surgery, chemotherapy, and radiotherapy. However, tumors often evade immune responses by altering the tumor microenvironment (TME), which recr...
Cerium-Based Materials for Theranostics: Building a Bridge Across the Divide From Antioxidant Therapy to Diagnostic Signals [0.03%]
铈基材料在诊疗学中的应用：从抗氧化治疗到诊断信号之间的桥梁构建
Liangchen Luo,Guozhu Yang,Pengli Zhang et al.
Liangchen Luo et al.
Oxidative stress (OS) serves as a fundamental pathological component in a multitude of chronic diseases, necessitating an all-round theranostic strategy for simultaneous precision intervention and real-time monitoring. Cerium-based nanomate...
Modeling Polymeric Drug Release: The Emerging Role of Machine Learning [0.03%]
基于机器学习的高分子药物释放模型及其作用机制研究
Ryan N Woodring,Kristy M Ainslie
Ryan N Woodring
Polymeric drug formulations have significantly improved the safety, efficacy, and clinical impact of many therapies. A persistent challenge for formulation scientists, however, lies in accurately characterizing time-dependent drug release. ...
Drug Product Development of Lipid Nanoparticle-Based mRNA Therapeutics and Vaccines [0.03%]
基于脂质纳米颗粒的mRNA治疗和疫苗药物产品的研发
Gideon Kersten,Eleonora Cerasoli,Bruce Kerwin et al.
Gideon Kersten et al.
Lipid nanoparticles (LNP) are currently the most relevant non-viral delivery systems for mRNA and occasionally for smaller nucleic acids such as small interfering RNA. Although the manufacturing of LNP is well established and scalable equip...
Nanoparticles-Mediated Modulation of TRP Channels: Advances and Therapeutic Potential [0.03%]
纳米颗粒介导的瞬时受体电位通道调节：进展与治疗潜力
Karina A Foster,Noy Midler,Ori Shine et al.
Karina A Foster et al.
Nanoparticles have emerged as promising tools for targeting and activating ion channels that serve as transducers for external signals. Their nanoscale dimensions enable targeted activation of ion channels at the cellular or subcellular lev...
Nanoengineered Niclosamide as a Microenvironment Modulator for Spinal Cord Regeneration: A Hypothetical Roadmap Toward Brain/Head Transplant Feasibility [0.03%]
用于脊髓再生的纳米工程尼克地美作为微环境调节剂：实现脑/头部移植可行性的假设路线图
N Sanoj Rejinold,Geun-Woo Jin,Jin-Ho Choy
N Sanoj Rejinold
Restoring long-distance spinal cord connectivity remains a major challenge in regenerative medicine. Despite advances in stem cell therapy, biomaterial scaffolds, and neuromodulation, recovery after spinal cord injury (SCI) is limited by a ...
Advances in Microbial Diagnostics: Machine Learning and Nanotechnology for Zoonotic Disease Control [0.03%]
微生物诊断进展：机器学习与纳米技术在人畜共患病防控中的应用
Narges Lotfalizadeh,Cinzia Santucciu,Valentina Chisu et al.
Narges Lotfalizadeh et al.
Zoonotic diseases pose significant global health threats, with microbial pathogens, including bacteria, viruses, fungi, and protozoa, responsible for severe outbreaks. The rapid identification and control of zoonotic pathogens remain a majo...
Recent Advances in Plasmon-Assisted Optical Sensing of Inflammatory Biomarkers [0.03%]
等离激元辅助光学炎症生物标志物检测最新进展
Daria Stoia,Alexandru-Milentie Hada,Sorina Suarasan et al.
Daria Stoia et al.
The precise monitoring of specific inflammatory biomarkers is crucial for the accurate diagnosis and management of inflammation and infections, as well as for determining the most effective treatment. Recently, there has been a growing inte...
Quentin M Perrin,Ali Miserez
Quentin M Perrin
Self-organizing tissues, such as organoids, offer transformative potential beyond healthcare by enabling the sustainable production of advanced materials. Resource scarcity and global warming drive the need for innovative fabrication soluti...
Precision Targeting of Hepatic Stellate Cells: Nanotherapeutic Strategies for Liver Fibrosis Regression [0.03%]
精准靶向肝星状细胞：抗肝纤维化纳米治疗策略
Xinying Ma,Dawei Chen,Ming Zhao et al.
Xinying Ma et al.
Liver fibrosis (LF), a major global health burden causing over two million deaths annually, arises from chronic injury leading to hepatic stellate cell (HSC) activation and pathological extracellular matrix (ECM) deposition. Current therapi...