Yixin Wang,Allie Barrett,Quanyin Hu
Yixin Wang
The adoptive transfer of T cells redirected by chimeric antigen receptors (CARs) has made a dramatic breakthrough in defeating hematological malignancies. However, in solid tumor treatment, CAR-T-cell therapy has attained limited therapeuti...
Shicheng Yang,Kushi Aggarwal,Jillian Jurczyszak et al.
Shicheng Yang et al.
In 2020, the top 10 causes of death among children and adolescents between the ages of 1 and 19 years old included cancer, congenital anomalies, heart disease, and chronic respiratory disease; all these conditions are potentially treatable ...
Nanoscale Radiotheranostics for Cancer Treatment: From Bench to Bedside [0.03%]
癌症治疗的纳米尺度放疗诊断技术：从实验台到病床
Xiaodan Jiao,Hao Hong,Weibo Cai
Xiaodan Jiao
In recent years, the application of radionuclides-containing nanomaterials in cancer treatment has garnered widespread attention. The diversity of nanomaterials allows researchers to selectively combine them with appropriate radionuclides f...
Daphika S Dkhar,Rohini Kumari,Vinay Patel et al.
Daphika S Dkhar et al.
Cancer is considered a formidable global health threat, despite substantial strides in diagnosis, detection, and therapeutic strategies. Remarkable progress has been achieved in these realms, yet the survival rates for cancer patients have ...
Hangping Liao,Jing Liao,Ling Zeng et al.
Hangping Liao et al.
Messenger RNA (mRNA) technology has rapidly evolved, significantly impacting various therapeutic applications, including vaccines, protein replacement, and gene editing. Lipid nanoparticles (LNPs) have emerged as a pivotal nonviral vector f...
Insights into the formulation of lipid nanoparticles for the optimization of mRNA therapeutics [0.03%]
脂质纳米颗粒的配方优化以改进mRNA疗法效力的见解
Xiangyu Jiao,Xi He,Shugang Qin et al.
Xiangyu Jiao et al.
mRNA-based therapeutics increasingly demonstrate significant potential in treating various diseases, including infectious diseases, cancers, and genetic disorders. Effective delivery systems are crucial for advancing mRNA therapeutics. Lipi...
Extracellular vesicles-based theranostics for neurodegenerative diseases [0.03%]
基于细胞外囊泡的神经退行性疾病诊疗一体化策略
Han Zhao,Ling Zhu,Chen Wang et al.
Han Zhao et al.
With the accelerated aging of the global population, the incidence of neurodegenerative diseases (NDDs) is increasing year by year. Because of the presence of the blood-brain barrier (BBB), the low concentration of the biomarkers in periphe...
Targeting specific brain districts for advanced nanotherapies: A review from the perspective of precision nanomedicine [0.03%]
精准纳米医学视角下的脑区特异性靶向纳米治疗药物研究进展
Giulia Sierri,Michela Patrucco,Davide Ferrario et al.
Giulia Sierri et al.
Numerous studies are focused on nanoparticle penetration into the brain functionalizing them with ligands useful to cross the blood-brain barrier. However, cell targeting is also crucial, given that cerebral pathologies frequently affect sp...
Exosomes in esophageal cancer: Promising nanocarriers in cancer progression, diagnosis, prognosis, and therapy [0.03%]
外泌体与食管癌：癌症进展、诊断、预后和治疗的前景纳米载体
Ligong Yuan,Haoran Ji,Yang Cao et al.
Ligong Yuan et al.
Esophageal cancer (EC) is one of the most fatal cancers all over the world. Sensitive detection modalities for early-stage EC and efficient treatment methods are urgently needed for the improvement of the prognosis of EC. Exosomes are small...
Polyester nanoparticles delivering chemotherapeutics: Learning from the past and looking to the future to enhance their clinical impact in tumor therapy [0.03%]
从过去汲取教训，展望未来以增强聚酯纳米颗粒在肿瘤治疗中的临床影响递送化学疗法
Giuseppe Longobardi,Thomas Lee Moore,Claudia Conte et al.
Giuseppe Longobardi et al.
Polymeric nanoparticles (NPs), specifically those comprised of biodegradable and biocompatible polyesters, have been heralded as a game-changing drug delivery platform. In fact, poly(α-hydroxy acids) such as polylactide (PLA), poly(lactide...