Nano Approaches to Nucleic Acid Delivery: Barriers, Solutions, and Current Landscape [0.03%]
纳米核酸递送策略：壁垒、解决方案和当前格局
Joan Castaneda Gonzalez,Ki Wan Park,Dallin Brian Evans et al.
Joan Castaneda Gonzalez et al.
Nucleic acid (NA) therapy holds tremendous potential for treating a wide range of genetic diseases by the delivery of therapeutic genes into target cells. However, significant challenges exist in safely and effectively delivering these gene...
Microscale Delivery Systems for Hydrophilic Active Ingredients in Functional Consumer Goods [0.03%]
亲水性活性成分的微载体递送系统研究进展及产业化应用探索
Zhirui Guan,Daniele Baiocco,Andre Barros et al.
Zhirui Guan et al.
Hydrophilic active ingredients play a crucial role in formulated consumer products, encompassing antioxidants, flavoring substances, and pharmaceuticals. Yet, their susceptibility to environmental factors, such as light, pH, temperature, an...
Robby Zwolsman,Youssef B Darwish,Ewelina Kluza et al.
Robby Zwolsman et al.
Over the last decades, messenger RNA (mRNA) has emerged as a promising therapeutic modality, enabling the delivery of genetic instructions to cells for producing therapeutic proteins or antigens. As such, mRNA-based therapies can be develop...
Role of Nanomedicine in Transforming Pharmacotherapy for Substance Use Disorder (SUD) [0.03%]
纳米医学在转化物质使用障碍药物治疗中的作用
Akshata Y Patne,Subhra Mohapatra,Shyam S Mohapatra
Akshata Y Patne
The field of nanomedicine offers revolutionary potential to reshape the discovery and development of therapeutics for diverse human diseases. However, its application has been limited in improving Substance Use Disorders (SUDs), which repre...
Spontaneous Self-Organized Order Emerging From Intrinsically Disordered Protein Polymers [0.03%]
来自内在无序蛋白聚合物的自发自组织顺序
Sergio Acosta,Pablo Rodríguez-Alonso,Viktoriya Chaskovska et al.
Sergio Acosta et al.
Intrinsically disordered proteins (IDPs) are proteins that, despite lacking a defined 3D structure, are capable of adopting dynamic conformations. This structural adaptability allows them to play not only essential roles in crucial cellular...
Nanoparticle Contrast Agents for Photon-Counting Computed Tomography: Recent Developments and Future Opportunities [0.03%]
光子计数CT中纳米颗粒对比剂的最新进展及未来机遇
Laxman Devkota,Rohan Bhavane,Cristian T Badea et al.
Laxman Devkota et al.
The clinical availability of photon-counting computed tomography (PCCT) has ushered in a new era of CT imaging. Spectral imaging coupled with superior contrast resolution, and ultrahigh spatial resolution (200 μm) offered by PCCT has the p...
Biomimetic Nanomaterials Based on Peptide In Situ Self-Assembly for Immunotherapy Applications [0.03%]
基于肽原位自组装的仿生纳米材料用于免疫治疗
Zhuan Wen,Zhang-Zhi Song,Ming-Ze Cai et al.
Zhuan Wen et al.
Cancer remains the leading cause of patient death worldwide and its incidence continues to rise. Immunotherapy is rapidly developing due to its significant differences in the mechanism of action from conventional radiotherapy and targeted a...
Tao Zhang,Giraso Keza Monia Kabandana,John A Terrell et al.
Tao Zhang et al.
Wearable sweat sensors for detecting biochemical markers have emerged as a transformative research area, with the potential to revolutionize disease diagnosis and human health monitoring. Since 2016, a substantial body of pioneering and tra...
Pulmonary Delivery of Nonviral Nucleic Acid-Based Vaccines With Spotlight on Gold Nanoparticles [0.03%]
基于金纳米颗粒的非病毒核酸疫苗的肺部给药
Carolina Araujo Cirne,Marianna Foldvari
Carolina Araujo Cirne
Nucleic acid-based vaccines are leading-edge tools in developing next-generation preventative care. Much research has been done to convert vaccine gene therapy from an invasive to a noninvasive administration approach. The lung's large surf...
Le Wang,Xiaoting Zhang,Lulu He et al.
Le Wang et al.
Iron-based nanomaterials (IBNMs) have been widely applied in biomedicine applications including magnetic resonance imaging, targeted drug delivery, tumor therapy, and so forth, due to their unique magnetism, excellent biocompatibility, and ...