An overview of lipid constituents in lipid nanoparticle mRNA delivery systems [0.03%]
脂质纳米颗粒mRNA递送系统中的脂质组分综述
Shiqi Wu,Lixin Lin,Lu Shi et al.
Shiqi Wu et al.
mRNA therapeutics have shown great potential for a broad spectrum of disease treatment. However, the challenges of mRNA's inherent instability and difficulty in cellular entry have hindered its progress in the biomedical field. To address t...
Sabrina Cuoghi,Riccardo Caraffi,Alessandro Anderlini et al.
Sabrina Cuoghi et al.
Enzyme-based therapy has garnered significant attention for its current applications in various diseases. Despite the notable advantages associated with the use of enzymes as therapeutic agents, that could have high selectivity, affinity, a...
Sample-to-answer salivary miRNA testing: New frontiers in point-of-care diagnostic technologies [0.03%]
从取样到得出结论的唾液miRNA检测：床旁诊断技术的新前沿
Zhikun Zhang,Tianyi Liu,Ming Dong et al.
Zhikun Zhang et al.
MicroRNA (miRNA), crucial non-coding RNAs, have emerged as key biomarkers in molecular diagnostics, prognosis, and personalized medicine due to their significant role in gene expression regulation. Salivary miRNA, in particular, stands out ...
Nanotechnology-driven strategies to enhance the treatment of drug-resistant bacterial infections [0.03%]
纳米技术驱动的策略增强治疗耐药细菌感染的效果
Junjie Zhang,Ming Liu,Haiyang Guo et al.
Junjie Zhang et al.
The misuse of antibiotics has led to increased bacterial resistance, posing a global public health crisis and seriously endangering lives. Currently, antibiotic therapy remains the most common approach for treating bacterial infections, but...
Liying Huang,Shicui Luo,Sen Tong et al.
Liying Huang et al.
Natural bioactive compounds from plants exhibit substantial pharmacological potency and therapeutic value. However, the development of most plant bioactive compounds is hindered by low solubility and instability. Conventional pharmaceutical...
Simon C Kellaway,Mathilde M Ullrich,Karolina Dziemidowicz
Simon C Kellaway
Nervous system injuries, encompassing peripheral nerve injury (PNI), spinal cord injury (SCI), and traumatic brain injury (TBI), present significant challenges to patients' wellbeing. Traditional treatment approaches have limitations in add...
Life at the interface: Engineering bio-nanomaterials through interfacial molecular self-assembly [0.03%]
界面生活——通过界面分子自组装工程生物纳米材料
Michael A Miller,Scott Medina
Michael A Miller
Interfacial self-assembly describes the directed organization of molecules and colloids at phase boundaries. Believed to be fundamental to the inception of primordial life, interfacial assembly is exploited by a myriad of eukaryotic and pro...
Iron oxide nanoparticles for treatment and diagnosis of chronic inflammatory diseases: A systematic review [0.03%]
铁纳米颗粒治疗和诊断慢性炎症疾病的系统性研究评论
Shaquib Rahman Ansari,Jessica Mahajan,Alexandra Teleki
Shaquib Rahman Ansari
Chronic inflammatory conditions are among the most prevalent diseases worldwide. Several debilitating diseases such as atherosclerosis, inflammatory bowel disease, rheumatoid arthritis, and Alzheimer's are linked to chronic inflammation. Th...
Rithvik Papani,Yang Li,Sihong Wang
Rithvik Papani
Wearable and implantable sensing of biomechanical signals such as pressure, strain, shear, and vibration can enable a multitude of human-integrated applications, including on-skin monitoring of vital signs, motion tracking, monitoring of in...
Exploring the properties and potential of the neural extracellular matrix for next-generation regenerative therapies [0.03%]
探究神经细胞外基质的性质和潜力以开发下一代再生疗法
J Alberto Ortega,Gisele P Soares de Aguiar,Palash Chandravanshi et al.
J Alberto Ortega et al.
The extracellular matrix (ECM) is a dynamic and complex network of proteins and molecules that surrounds cells and tissues in the nervous system and orchestrates a myriad of biological functions. This review carefully examines the diverse i...