Complete Local and Abscopal Responses from a Combination of Radiation and Nivolumab in Refractory Hodgkin's Lymphoma [0.03%]
放疗联合纳武单抗治疗难治性霍奇金淋巴瘤的疗效：局部及远处完全缓解
Qian Qin,Xinyu Nan,Tara Miller et al.
Qian Qin et al.
Until recently, patients with relapsed Hodgkin's lymphoma after brentuximab vedotin (Bv) treatments had poor treatment outcomes. Checkpoint inhibitors such as nivolumab and pembrolizumab that bind to and inhibit programmed cell death protei...
Modeling Cell and Tumor-Metastasis Dosimetry with the Particle and Heavy Ion Transport Code System (PHITS) Software for Targeted Alpha-Particle Radionuclide Therapy [0.03%]
采用粒子和重离子输运代码系统（PHITS）软件进行细胞及肿瘤转移剂量学建模的靶向α粒子核素治疗研究
Dongyoul Lee,Mengshi Li,Bryan Bednarz et al.
Dongyoul Lee et al.
The use of targeted radionuclide therapy for cancer is on the rise. While beta-particle-emitting radionuclides have been extensively explored for targeted radionuclide therapy, alpha-particle-emitting radionuclides are emerging as effective...
Impact of Inter-Individual Variance in the Expression of a Radiation-Responsive Gene Panel Used for Triage [0.03%]
用于分类的辐射应答基因组表达个体差异的影响研究
S Agbenyegah,M Abend,M J Atkinson et al.
S Agbenyegah et al.
In previous studies we determined a gene expression signature in baboons for predicting the severity of hematological acute radiation syndrome. We subsequently validated a set of eight of these genes in leukemia patients undergoing total-bo...
Mechanisms and Characterization of the Pulsed Electron-Induced Grafting of Styrene onto Poly(tetrafluoroethylene-co-hexafluoropropylene) to Prepare a Polymer Electrolyte Membrane [0.03%]
脉冲电子引发苯乙烯接枝改性聚(四氟乙烯-共-六氟丙烯)制备聚合物电解质膜及其表征研究
Byungnam Kim,Alia Weaver,Marina Chumakov et al.
Byungnam Kim et al.
During the pulsed-electron beam direct grafting of neat styrene onto poly(tetrafluoroethylene-co-hexafluoropropylene) (FEP) substrate, the radiolytically-produced styryl and carbon-centered FEP radicals undergo various desired and undesired...
Ferulic Acid Mitigates Radiation Injury in Human Umbilical Vein Endothelial Cells In Vitro via the Thrombomodulin Pathway [0.03%]
金丝桃素通过血栓调节蛋白通路体外缓解辐射引起的内皮细胞损伤
Shuai Shao,Yue Gao,Jianxiang Liu et al.
Shuai Shao et al.
Cell death and tissue injury occur as a result of radiation accidents and radiotherapy. The role of endothelial cell damage in mediating radiation-induced acute tissue injury has been extensively studied. We previously demonstrated that fer...
Mitochondrial Dysfunctions Regulated Radioresistance through Mitochondria-to-Nucleus Retrograde Signaling Pathway of NF-κB/PI3K/AKT2/mTOR [0.03%]
线粒体功能障碍通过NF-κB/PI3K/AKT2/mTOR信号通路调控放射抵抗的分子机制研究
Yuehua Wei,Lulu Chen,Hui Xu et al.
Yuehua Wei et al.
We investigated the relationship between significantly different genes of the mitochondria-to-nucleus retrograde signaling pathway (RTG) in H1299 ρ0 cells (mtDNA depleted cell) and compared their radiosensitivity to that of parental ρ+ ce...
Fruit Flies Provide New Insights in Low-Radiation Background Biology at the INFN Underground Gran Sasso National Laboratory (LNGS) [0.03%]
意大利国家粒子物理研究所格兰萨索国家实验室(LNGS)地下低辐射背景下果蝇生物学的新见解
Patrizia Morciano,Francesca Cipressa,Antonella Porrazzo et al.
Patrizia Morciano et al.
Deep underground laboratories (DULs) were originally created to host particle, astroparticle or nuclear physics experiments requiring a low-background environment with vastly reduced levels of cosmic-ray particle interference. More recently...
Imaging Potential Evaluation of Fab Derived from the Anti-EGFRvIII Monoclonal Antibody 4G1 [0.03%]
来自抗EGFR变异III单克隆抗体4G1的片段结晶体在成像潜力评估方面的应用
Shen Jing,Yujia He,Yanqiong He et al.
Shen Jing et al.
As one of the most crucial epidermal growth factor receptor (EGFR) variants, EGFRvIII can be detected in various tumors but rarely in normal tissues, making it an ideal target for prognosis, diagnosis or immune therapy. The recently develop...
In Vitro Cell-free DNA Quantification: A Novel Method to Accurately Quantify Cell Survival after Irradiation [0.03%]
体外无细胞DNA定量：一种准确量化辐射后细胞存活率的新方法
Christopher R Deig,Rachel T Thowe,Elizabeth D Frye et al.
Christopher R Deig et al.
Circulating tumor DNA (ctDNA) analysis has been shown to aid in both the detection of cancer and evaluation of somatic mutations in tumors. CtDNA concentration in plasma increases in proportion to tumor volume and/or metabolic activity and ...
Selective Insulin-like Growth Factor Resistance Associated with Heart Hemorrhages and Poor Prognosis in a Novel Preclinical Model of the Hematopoietic Acute Radiation Syndrome [0.03%]
选择性胰岛素样生长因子抵抗与心脏出血和预后不良有关——造血急性辐射综合征的新临床前模型研究
Doreswamy Kenchegowda,Betre Legesse,Bernadette Hritzo et al.
Doreswamy Kenchegowda et al.
Although bone marrow aplasia has been considered for the past decades as the major contributor of radiation-induced blood disorders, cytopenias alone are insufficient to explain differences in the prevalence of bleeding. In this study, the ...