A Potential Biomarker for Predicting the Risk of Radiation-Induced Fibrosis in the Lung [0.03%]
预测放射性肺纤维化风险的潜在生物标志物
Angela M Groves,Jacqueline P Williams,Eric Hernady et al.
Angela M Groves et al.
Biomarkers could play an essential role during triage in the aftermath of a radiological event, where exposure to radiation will be heterogeneous and complicated by concurrent trauma. Used alongside biodosimetry, biomarkers can identify vic...
Target Size Variation in Microdosimetric Distributions and its Impact on the Linear-Quadratic Parameterization of Cell Survival [0.03%]
靶体积变化对微剂量分布及细胞存活的线性二次参数化的影响研究
Fernanda Villegas,Nina Tilly,Anders Ahnesjö
Fernanda Villegas
The linear-quadratic (LQ) parameterization of survival fraction [SF( D)] inherently assumes that all cells in a population receive the same dose ( D), albeit the distribution of specific energy z over the individual cells f( z, D) can be ve...
Autophagy-Src Regulates Connexin43-Mediated Gap Junction Intercellular Communication in Irradiated HepG2 Cells [0.03%]
自噬-Src调节辐射诱导的HepG2细胞Cx43介导的通讯连接功能
Xiaoyao Yang,Shengmin Xu,Yao Su et al.
Xiaoyao Yang et al.
Connexin molecules are an important component of the gap junction, with connexin43 (Cx43) being the most abundantly expressed type. Src is a nonreceptor tyrosine-protein kinase that affects Cx43 activity by multiple mechanisms. However, it ...
Exposure to Ionizing Radiation Causes Endoplasmic Reticulum Stress in the Mouse Hippocampus [0.03%]
离子辐射可致小鼠海马内质网应激反应增强
Charles P Hinzman,Janet E Baulch,Khyati Y Mehta et al.
Charles P Hinzman et al.
It is well known that ionizing radiation-induced toxicity to normal tissue has functional consequences in the brain. However, the underlying molecular alterations have yet to be elucidated. We have previously reported cognitive impairments ...
DosiKit, a New Immunoassay for Fast Radiation Biodosimetry of Hair and Blood Samples [0.03%]
Dosikit快速辐射生物剂量检测新方法及头发和血液样品免疫测定模型的建立
Julie Bensimon Etzol,Samuel Bouvet,Caroline Bettencourt et al.
Julie Bensimon Etzol et al.
DosiKit is a field radiation biodosimetry immunoassay for fast triage of individuals exposed to external total-body or partial-body irradiation (TBI or PBI). Assay proof-of-concept based on γ-H2AX analysis of human blood samples has been p...
Proteomic Changes in Mouse Spleen after Radiation-Induced Injury and its Modulation by Gamma-Tocotrienol [0.03%]
γ-生育三烯醇干预辐射致小鼠脾损伤的蛋白质组变化分析
Amrita K Cheema,Stephanie D Byrum,Neel Kamal Sharma et al.
Amrita K Cheema et al.
Gamma-tocotrienol (GT3), a naturally occurring vitamin E isomer, a promising radioprotector, has been shown to protect mice against radiation-induced hematopoietic and gastrointestinal injuries. We analyzed changes in protein expression pro...
Enhancement of Soft Tissue Sarcoma Cell Radiosensitivity by Poly(ADP-ribose) Polymerase-1 Inhibitors [0.03%]
聚(腺苷二磷酸核糖)聚合酶-1抑制剂增强软组织肉瘤细胞放射敏感性
Monica Mangoni,Mariangela Sottili,Giulia Salvatore et al.
Monica Mangoni et al.
Soft tissue sarcomas (STS) are aggressive tumors with a poor prognosis. Poly(ADP-ribose) polymerase (PARP)-1 inhibitors (PARPi) enhance the cytotoxic effects of radiation. In this study, we evaluated the effect of PARPi on survival and DNA ...
Incidence of Breast Cancer in the Life Span Study of Atomic Bomb Survivors: 1958-2009 [0.03%]
《 atomic bomb survivors生命周期研究中的乳腺癌发病率：1958-2009》
Alina V Brenner,Dale L Preston,Ritsu Sakata et al.
Alina V Brenner et al.
The importance of reproductive history in breast tissue development and etiology of sporadic breast cancer in females is well established. However, there is limited evidence of factors, other than age, that modify risk of radiation-related ...
Defenses against Pro-oxidant Forces - Maintenance of Cellular and Genomic Integrity and Longevity [0.03%]
对抗促氧化因素的作用：维持细胞和基因组的完整性和长寿抗氧化防御体系中的Nrf2诱导基因抗氧化反应元件依赖型和独立型信号通路
David Murray,Razmik Mirzayans,William H McBride
David Murray
There has been enormous recent progress in understanding how human cells respond to oxidative stress, such as that caused by exposure to ionizing radiation. We have witnessed a significant deciphering of the events that underlie how antioxi...
Yoshitaka Matsumoto,Yoshiya Furusawa,Akiko Uzawa et al.
Yoshitaka Matsumoto et al.
The goal of this work was to clarify the effect of carbon-ion beams on reduction of the metastatic potential of malignant melanoma using in vitro and in vivo techniques. We utilized a 290 MeV/u carbon beam with a 6-cm spread-out Bragg-peak ...