Defenses against Pro-oxidant Forces - Maintenance of Cellular and Genomic Integrity and Longevity [0.03%]
对抗促氧化因素的作用：维持细胞和基因组的完整性和长寿抗氧化防御体系中的Nrf2诱导基因抗氧化反应元件依赖型和独立型信号通路
David Murray,Razmik Mirzayans,William H McBride
David Murray
There has been enormous recent progress in understanding how human cells respond to oxidative stress, such as that caused by exposure to ionizing radiation. We have witnessed a significant deciphering of the events that underlie how antioxi...
Yoshitaka Matsumoto,Yoshiya Furusawa,Akiko Uzawa et al.
Yoshitaka Matsumoto et al.
The goal of this work was to clarify the effect of carbon-ion beams on reduction of the metastatic potential of malignant melanoma using in vitro and in vivo techniques. We utilized a 290 MeV/u carbon beam with a 6-cm spread-out Bragg-peak ...
Chromosomal Abnormalities in Human Lymphocytes after Computed Tomography Scan Procedure [0.03%]
计算机断层扫描后人体淋巴细胞染色体异常的研究
Lin Shi,Kurumi Fujioka,Nami Sakurai-Ozato et al.
Lin Shi et al.
The incidence of chromosomal abnormalities and cancer risk correlates well with the radiation dose after exposure to moderate- to high-dose ionizing radiation. However, the biological effects and health risks at less than 100 mGy, e.g., fro...
Antifibrotic Agent Pirfenidone Protects against Development of Radiation-Induced Pulmonary Fibrosis in a Murine Model [0.03%]
抗纤维化药物Pirfenidone能够保护小鼠免于放射性肺纤维病的侵害
Wan Qin,Bo Liu,Minxiao Yi et al.
Wan Qin et al.
Radiation-induced complications of the respiratory system are a common side effect of thoracic radiotherapy with no viable treatment option. Here, we investigated the potential therapeutic effect of the orphan drug pirfenidone for treating ...
Fibronectin Produced by Cerebral Endothelial and Vascular Smooth Muscle Cells Contributes to Perivascular Extracellular Matrix in Late-Delayed Radiation-Induced Brain Injury [0.03%]
脑内皮细胞和血管平滑肌细胞来源的纤连蛋白促进放射性脑病后期损伤外周血管基底膜形成增多
Rachel N Andrews,David L Caudell,Linda J Metheny-Barlow et al.
Rachel N Andrews et al.
Late-delayed radiation-induced brain injury (RIBI) is a major adverse effect of fractionated whole-brain irradiation (fWBI). Characterized by progressive cognitive dysfunction, and associated cerebrovascular and white matter injury, RIBI de...
Blocking Endogenous H2S Signaling Attenuated Radiation-Induced Long-Term Metastasis of Residual HepG2 Cells through Inhibition of EMT [0.03%]
通过抑制上皮间质转化阻止内源性H2S信号途径可减弱辐射引起的残留肝癌细胞长期转移性增强的现象
Hang Zhang,Yimeng Song,Cuiping Zhou et al.
Hang Zhang et al.
Recurrence and metastasis of hepatocellular carcinoma (HCC) after radiotherapy are frequently observed in clinical practice. To date, the involved mechanism, endogenous hydrogen sulfide (H2S), has not been well understood and warrants inves...
Martin Šefl,Kateřina Pachnerová Brabcová,Václav Štěpán
Martin Šefl
Experimental radiobiological studies in which the effects of ionizing radiation on a biological model are examined often highlight the biological aspects while missing detailed descriptions of the geometry, sample and dosimetric methods use...
Energy Spectra of Protons and Generated Secondary Electrons around the Bragg Peak in Materials of Interest in Proton Therapy [0.03%]
用于质子治疗的材料中布拉格峰附近的质子能谱及次级电子生成能谱
Pablo de Vera,Isabel Abril,Rafael Garcia-Molina
Pablo de Vera
The number and energy of secondary electrons generated around the trajectories of swift protons interacting with biological materials are highly relevant in proton therapy, due to the prominent role of low-energy electrons in the production...
Tetrandrine Enhances Radiosensitization in Human Hepatocellular Carcinoma Cell Lines [0.03%]
蝙蝠葛苏林通过增强线粒体应激促进人类肝癌细胞放射增敏作用
Xiao-Mei Zhao,Wei-Xu Hu,Zhi-Feng Wu et al.
Xiao-Mei Zhao et al.
The goal of this study was to determine whether tetrandrine enhanced radiosensitization in different hepatocellular carcinoma cell lines and to elucidate the potential mechanism. We also tested whether PA28γ was regulated by tetrandrine. T...
Analysis of Exposure to Solar and Galactic Cosmic Radiations of Flights Representative of the European International Air Traffic [0.03%]
欧洲国际航空交通航班太阳辐射和银河宇宙射线暴露分析
Guillaume Hubert,Sébastien Aubry
Guillaume Hubert
This study analyzed the impact of galactic and solar cosmic rays on ambient dose equivalent during airline travel. A high statistic of flights are considered, which is representative of European international air traffic. Flight paths are b...