Differential Radiation Sensitivity in p53 Wild-Type and p53-Deficient Tumor Cells Associated with Senescence but not Apoptosis or (Nonprotective) Autophagy [0.03%]
与衰老而非凋亡或非保护自噬有关的p53野生型和p53缺陷型肿瘤细胞的放射敏感性差异
Jingwen Xu,Nipa H Patel,Tareq Saleh et al.
Jingwen Xu et al.
Studies of radiation interaction with tumor cells often focus on apoptosis as an end point; however, clinically relevant doses of radiation also promote autophagy and senescence. Moreover, functional p53 has frequently been implicated in co...
Accelerator-Based Tests of Shielding Effectiveness of Different Materials and Multilayers using High-Energy Light and Heavy Ions [0.03%]
基于加速器的轻离子和重离子高能量束流对不同材料及多层组合屏蔽效果的测试研究
Martina Giraudo,Christoph Schuy,Uli Weber et al.
Martina Giraudo et al.
The roadmap for space exploration foresees longer journeys and further excursions outside low-Earth orbit as well as the establishment of permanent outposts on other celestial bodies, such as the Moon or Mars. The design of spacecrafts and ...
A Potential Biomarker for Predicting the Risk of Radiation-Induced Fibrosis in the Lung [0.03%]
预测放射性肺纤维化风险的潜在生物标志物
Angela M Groves,Jacqueline P Williams,Eric Hernady et al.
Angela M Groves et al.
Biomarkers could play an essential role during triage in the aftermath of a radiological event, where exposure to radiation will be heterogeneous and complicated by concurrent trauma. Used alongside biodosimetry, biomarkers can identify vic...
Target Size Variation in Microdosimetric Distributions and its Impact on the Linear-Quadratic Parameterization of Cell Survival [0.03%]
靶体积变化对微剂量分布及细胞存活的线性二次参数化的影响研究
Fernanda Villegas,Nina Tilly,Anders Ahnesjö
Fernanda Villegas
The linear-quadratic (LQ) parameterization of survival fraction [SF( D)] inherently assumes that all cells in a population receive the same dose ( D), albeit the distribution of specific energy z over the individual cells f( z, D) can be ve...
Autophagy-Src Regulates Connexin43-Mediated Gap Junction Intercellular Communication in Irradiated HepG2 Cells [0.03%]
自噬-Src调节辐射诱导的HepG2细胞Cx43介导的通讯连接功能
Xiaoyao Yang,Shengmin Xu,Yao Su et al.
Xiaoyao Yang et al.
Connexin molecules are an important component of the gap junction, with connexin43 (Cx43) being the most abundantly expressed type. Src is a nonreceptor tyrosine-protein kinase that affects Cx43 activity by multiple mechanisms. However, it ...
Exposure to Ionizing Radiation Causes Endoplasmic Reticulum Stress in the Mouse Hippocampus [0.03%]
离子辐射可致小鼠海马内质网应激反应增强
Charles P Hinzman,Janet E Baulch,Khyati Y Mehta et al.
Charles P Hinzman et al.
It is well known that ionizing radiation-induced toxicity to normal tissue has functional consequences in the brain. However, the underlying molecular alterations have yet to be elucidated. We have previously reported cognitive impairments ...
DosiKit, a New Immunoassay for Fast Radiation Biodosimetry of Hair and Blood Samples [0.03%]
Dosikit快速辐射生物剂量检测新方法及头发和血液样品免疫测定模型的建立
Julie Bensimon Etzol,Samuel Bouvet,Caroline Bettencourt et al.
Julie Bensimon Etzol et al.
DosiKit is a field radiation biodosimetry immunoassay for fast triage of individuals exposed to external total-body or partial-body irradiation (TBI or PBI). Assay proof-of-concept based on γ-H2AX analysis of human blood samples has been p...
Proteomic Changes in Mouse Spleen after Radiation-Induced Injury and its Modulation by Gamma-Tocotrienol [0.03%]
γ-生育三烯醇干预辐射致小鼠脾损伤的蛋白质组变化分析
Amrita K Cheema,Stephanie D Byrum,Neel Kamal Sharma et al.
Amrita K Cheema et al.
Gamma-tocotrienol (GT3), a naturally occurring vitamin E isomer, a promising radioprotector, has been shown to protect mice against radiation-induced hematopoietic and gastrointestinal injuries. We analyzed changes in protein expression pro...
Enhancement of Soft Tissue Sarcoma Cell Radiosensitivity by Poly(ADP-ribose) Polymerase-1 Inhibitors [0.03%]
聚(腺苷二磷酸核糖)聚合酶-1抑制剂增强软组织肉瘤细胞放射敏感性
Monica Mangoni,Mariangela Sottili,Giulia Salvatore et al.
Monica Mangoni et al.
Soft tissue sarcomas (STS) are aggressive tumors with a poor prognosis. Poly(ADP-ribose) polymerase (PARP)-1 inhibitors (PARPi) enhance the cytotoxic effects of radiation. In this study, we evaluated the effect of PARPi on survival and DNA ...
Incidence of Breast Cancer in the Life Span Study of Atomic Bomb Survivors: 1958-2009 [0.03%]
《 atomic bomb survivors生命周期研究中的乳腺癌发病率：1958-2009》
Alina V Brenner,Dale L Preston,Ritsu Sakata et al.
Alina V Brenner et al.
The importance of reproductive history in breast tissue development and etiology of sporadic breast cancer in females is well established. However, there is limited evidence of factors, other than age, that modify risk of radiation-related ...